What does The Column Group invest in?
The Column Group invests most often at Series A and Series B (73% of the rounds on record), in sectors such as Life Sciences.

United States · Investor
Last cheque observed Oct 2026; 46 cheques on record.
Deploying nowNew fund $100M, Dec 2025VC firm
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1 cheques in the last 12 months
Mostly Series A and Series B: 73% of its rounds
Sole investor in 4 rounds, median $24M
3 exits from the portfolio
The Column Group (TCG) is a venture ecosystem dedicated to fueling scientific innovation in the life sciences industry.From their own website
Every round we can evidence, newest first46 appearances
1 round
4 rounds
7 rounds
4 rounds
1 round
3 rounds
3 rounds
1 round
5 rounds
3 rounds
4 rounds
7 rounds
An announcement gives the size of the round, not the size of this investor's cheque: the only rounds that imply a cheque are those where they were the sole named investor.
Named by the firm itself, on a filing, its Form ADV or its company registration14 named
We also hold 23 people at this firm from the lists this database was built from: a weaker source than the filings, since a list does not say when a title ended. Login to see them.
From the firm's own filings with the SEC, which it must file accurately by law
From their own portfolio page (on their website)
Thumbnail for A2 BiotherapeuticsThumbnail for Arcus BiosciencesThumbnail for Circle PharmaThumbnail for KallyopeThumbnail for Oric PharmaceuticalsThumbnail for Peloton TherapeuticsThumbnail for PlexiumThumbnail for Revolution MedicinesThumbnail for SurrozenThumbnail for Tenaya TherapeuticsNovartisThumbnail for Aragon PharmaceuticalsThumbnail for Atavistik BioThumbnail for Carmot TherapeuticsThumbnail for Escient PharmaceuticalsThumbnail for Gritstone BioThumbnail for Hexagon BioThumbnail for Immune DesignThumbnail for Judo BioThumbnail for Lyterian TherapeuticsThumbnail for Neurona TherapeuticsThumbnail for Ngm BioThumbnail for Nura BioThumbnail for Rapt TherapeuticsThumbnail for Seragon PharmaceuticalsThumbnail for SyntheXThumbnail for SynthekineThumbnail for Tortugas NeuroscienceThumbnail for Tr1x Bio
Weaker than a round we watched, stronger than a list somebody sold us. A firm is far less willing to put a company on its own site that it never funded.
Companies it backed that were later bought or listed3 in all
An exit counts when it came after the firm's first round in the company. From historical deal records.
The investors most often in the same rounds as The Column Group. A count of rooms they were both in, not a relationship either has claimed.
The latest companies The Column Group put money into.
The Column Group invests most often at Series A and Series B (73% of the rounds on record), in sectors such as Life Sciences.
46 investments on record, 1 of them in the last 12 months, and it led 2. The most recent was in Oct 2026.
Its most recent investments on record: TriGemX Bio (Undisclosed round, Oct 2026), A2 Biotherapeutics (Series A, Nov 2019) and Plexium (Series A, Oct 2019).
The median round it joins is $57M. It says it writes cheques of $100K to $5.0M.
Sometimes: it led 2 of its 46 investments on record (4%).
Most of the companies it backs are in the United States (100%).
Yes: it is actively investing, with 1 investments in the last 12 months.
Most often Third Rock Ventures (11 rounds together), OrbiMed (10 rounds together) and Versant Ventures (6 rounds together).
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Built from the rounds we watched, its filings and its own website, refreshed every night. How we count · Report a correction · Is this your firm? Claim it