United States · Investor

Lightstone Ventures

Last cheque observed Aug 2025. Silence since then is not evidence of inactivity: our sources miss unannounced rounds.

QuietNew fund $375M, Sept 2021VC firm

SeedSeries ASeries BLifesciencePsychedelicsIvd

Cheques on record
0%of best year0cheques in 12 months, 22 on record
Since the last cheque433days00hrs00min00sec
Median round$61MCheque size, as they say$100K – $5.0MRounds led1 of 22Mostly inUnited States, 86%
Pitch Lightstone Ventures

Lightstone Ventures highlights

  1. 01

    22 rounds on record

  2. 02

    Mostly Series B and Series A: 76% of its rounds

  3. 03

    Led 1 rounds

What they do

Our experienced life science investors seek out visionary founders to translate novel scientific breakthroughs into clinically and commercially meaningful therapies.From their own website
Type
VC firm (from a list, unverified)
Cheque size
$100K – $5.0M as they say
Stages
SeedSeries ASeries BGrowthPre-IPO
Sectors
LifesciencePsychedelicsIvd
Based in
Portola Valley, United States
Cold pitches
Not stated

The record

Every round we can evidence, newest first22 appearances

  1. 2025

    4 rounds

  2. Aug
    ProVerum MedicalSeries B · IE · Crunchbase News$80MWith 7 others
  3. Aug
    Apreo HealthSeries B · US · TechStartups$130MWith 6 others
  4. Jun
  5. Apr
    Atsena TherapeuticsSeries C · US · Hatteras Venture Partners$150MWith 9 others
  6. 2021

    1 round

  7. Aug
    Vigil NeuroscienceSeries B · US · Hatteras Venture Partners$90MWith 12 others
  8. 2019

    4 rounds

  9. Oct
    Cyteir TherapeuticsUS · FinSMEs$40MWith 5 others
  10. Sept
    Bold PenguinSeries B · US · VentureBeat$32MWith 3 others
  11. May
    LocanaSeries A · US · FinSMEs$55MWith 4 others
  12. Feb
    NuvairaUS · FinSMEs$79MWith 9 others
  13. 2018

    4 rounds

  14. Oct
    EarlensUS · Prnewswire$87MWith 15 others
  15. Jun
    NimbusUS · FinSMEs$65MWith 6 others
  16. Mar
    CyteirSeries B · US · FinSMEs$29MWith 2 others
  17. Jan
    Fire1Series C · IE · Siliconrepublic$50MWith 4 others
  18. 2017

    2 rounds

  19. Oct
    Gemini TherapeuticsSeries A · US · FinSMEs$43MWith 2 others
  20. Jun
    EarlensDebt · US · FinSMEs$118MWith 9 others
  21. 2016

    1 round

  22. Dec
    CerevanceSeries A · US · FinSMEs$22MWith 1 other
  23. 2015

    2 rounds

  24. Jul
    Ra PharmaceuticalsSeries B · US$59MWith 8 others
  25. Mar
    Nimbus TherapeuticsSeries B · US$43MWith 5 others
  26. 2014

    3 rounds

  27. Sept
    Flex PharmaVenture · US$40MWith 9 others
  28. Aug
    Claret MedicalSeries B · US$18MWith 2 others
  29. Jan
    FIRE1Series A · IEUndisclosedWith 2 others
  30. 2013

    1 round

  31. Nov
    Catabasis PharmaceuticalsSeries B · US · finsmes.com$32MWith 4 others

An announcement gives the size of the round, not the size of this investor's cheque: the only rounds that imply a cheque are those where they were the sole named investor.

The team

Named by the firm itself, on a filing, its Form ADV or its company registration9 named

CKChristina Kaldany IsacsonMember of Lsv Associates III, LLCiForm ADV
HAHenry A. Plain, Jr.Managing Director of the general partnersiFiling they signed
HAHenry Albert PlainDirector of Lightstone Singapore Associates, LLCiForm ADV
JLJaclyn LettmannMember of Lightstone Singapore Associates, LLCiForm ADV
JWJason W. LettmannManager of the General PartneriFiling they signed
JMJean M. GeorgeMember/Director of Lightstone Singapore Associates, LLCiForm ADV
MAMichael A. CarusiDirector of Lightstone Singapore Associates, LLCiForm ADV
RERalph Earl ChristoffersenManaging Director of the general partnersiFiling they signed
TJTravis John BoettnerChief Financial OfficeriForm ADV

We also hold 18 people at this firm from the lists this database was built from: a weaker source than the filings, since a list does not say when a title ended. Login to see them.

What the register says

From the firm's own filings with the SEC, which it must file accurately by law

$553Mgross assets of its fundsOct 2026
Exemptreporting adviserventure or small private funds
Legal name
LSV Capital Management, LLC
SEC number
CRD 168121

What they claim to have backed

From their own portfolio page (on their website)

25 of 42 we have independently watched raise

AcceleronpharmaAlxoncologyCalahealthCarricktherapeuticsCerevanceClaretmedicalContegomedicalCyteirEndogastricsolutionsFire1foundryFlex-pharmaGynesonicsHydrabiosciencesMersanaMoximedPlexxikonPortolaProverummedicalRelievantSetpointmedicalShoulderinnovationsTallactherapeuticsThefoundryVerastemVolta-medical65lab.sgAlchemabBioVenture VoiCes EpisodeBonitobioCardiacboosterCoolsculptingFiveprimeMicroventionPowervisionlensProVerum ProVee SystemProVerum’s CFO HirePsitheraRapharmaReprievecardioTagworkspharmaTrotanaVigilneuro

Weaker than a round we watched, stronger than a list somebody sold us. A firm is far less willing to put a company on its own site that it never funded.

Who they invest alongside

The investors most often in the same rounds as Lightstone Ventures. A count of rooms they were both in, not a relationship either has claimed.

Recently backed

The latest companies Lightstone Ventures put money into.

Quick answers about Lightstone Ventures

What does Lightstone Ventures invest in?

Lightstone Ventures invests most often at Series B and Series A (76% of the rounds on record), in sectors such as Lifescience, Psychedelics and Ivd.

How active is Lightstone Ventures?

22 investments on record, 0 of them in the last 12 months, and it led 1. The most recent was in Aug 2025.

What has Lightstone Ventures invested in recently?

Its most recent investments on record: ProVerum Medical (Series B, Aug 2025), Apreo Health (Series B, Aug 2025) and Allay Therapeutics (Series D, Jun 2025).

How big are Lightstone Ventures's cheques?

The median round it joins is $61M. It says it writes cheques of $100K to $5.0M.

Does Lightstone Ventures lead rounds?

Sometimes: it led 1 of its 22 investments on record (5%).

Where does Lightstone Ventures invest?

Most of the companies it backs are in the United States (86%) and Ireland (14%).

Is Lightstone Ventures investing now?

No investments in the last 12 months; the latest was in Aug 2025.

Who does Lightstone Ventures invest alongside?

Most often New Enterprise Associates (6 rounds together), Atlas Venture (3 rounds together) and OrbiMed (3 rounds together).

Raising now?

Find the investors who back rounds like yours, and keep every conversation on one fundraising board.

Built from the rounds we watched, its filings and its own website, refreshed every night. How we count · Report a correction · Is this your firm? Claim it