United States · Investor

Flagship Pioneering

Last cheque observed Apr 2026; 53 cheques on record.

Deploying nowNew fund $2.6B, Nov 2024VC firm

SeedSeries ASeries BEhealthHealth-techHealthtech

Deploying now
36%of best year4cheques in 12 months, 53 on record
Since the last cheque213days00hrs00min00sec
Median round$50MRounds led0 of 53Sole investor17 roundsMostly inUnited States, 97%
Pitch Flagship Pioneering

Flagship Pioneering highlights

  1. 01

    4 cheques in the last 12 months

  2. 02

    Mostly Series A and Venture: 53% of its rounds

  3. 03

    Sole investor in 17 rounds, median $50M

What they do

Pioneering Partnerships Latest NewsFrom their own website
Type
VC firm (from a list, unverified)
Cheque size
Up to $5.0M as they say
Stages
SeedSeries ASeries BGrowthPre-IPO
Sectors
EhealthHealth-techHealthtech
Based in
Cambridge, United States
Cold pitches
Not accepted

The record

Every round we can evidence, newest first53 appearances

  1. 2026

    3 rounds

  2. Apr
    Metaphore BiotechnologiesVenture · USUndisclosedWith 1 other
  3. Apr
    Serif Bio­med­i­cinesVenture · US$50MSole investor
  4. Jan
    Foghorn TherapeuticsUS$50MWith 3 others
  5. 2025

    11 rounds

  6. Dec
    Denali TherapeuticsDebt · US$200MWith 3 others
  7. Oct
    Seres TherapeuticsGrant · US$3.6MWith 2 others
  8. Oct
    Expedition MedicinesSeries A · US$50MSole investor
  9. Sept
    Lila SciencesSeries A · US · TechStartups$235MWith 21 others
  10. Sept
    ExtuitiveSeed · US$20MSole investor
  11. Jul
    Terrana BiosciencesSeries B · US$50MSole investor
  12. Apr
    EtiomeSeries A · US$50MSole investor
  13. Mar
    IndigoVenture · US$1.5MWith 1 other
  14. Mar
    Lila SciencesSeed · US · AlleyWatch$200MWith 8 others
  15. Mar
    Ampersand BiomedicinesSeries B · US$65MWith 1 other
  16. Jan
    HarbingerSeries B · US · TechCrunch$100MWith 14 others
  17. 2024

    4 rounds

  18. Sept
    Mirai BioSeries A · US$50MSole investor
  19. Jul
    Apriori BioGrant · US$1.1MSole investor
  20. May
    Prologue MedicinesSeries A · US$50MSole investor
  21. Jan
    CIBOVenture · USUndisclosedWith 2 others
  22. 2023

    7 rounds

  23. Nov
    Quotient TherapeuticsSeed · GB$50MSole investor
  24. Aug
    AlltrnaSeries B · US$109MSole investor
  25. Jul
    Evelo BiosciencesUS$26MWith 2 others
  26. Jun
    Empress TherapeuticsVenture · US$50MSole investor
  27. May
    Metaphore BiotechnologiesVenture · US$50MSole investor
  28. Mar
    Ring TherapeuticsSeries C · US$87MWith 3 others
  29. Feb
    Omega TherapeuticsUS$40MWith 3 others
  30. 2022

    8 rounds

  31. Dec
    Montai TherapeuticsSeries A · US$50MSole investor
  32. Oct
    CellaritySeries C · US$121MWith 1 other
  33. Oct
    AxcellaUS$34MWith 1 other
  34. Oct
    Valo HealthVenture · USUndisclosedWith 3 others
  35. Sept
    Codiak BiosciencesUS$20MWith 4 others
  36. Aug
    Senda BiosciencesSeries C · US$123MWith 3 others
  37. May
    ProFound TherapeuticsSeries A · US$75MSole investor
  38. Mar
    Vesalius TherapeuticsSeries A · US$75MSole investor
  39. 2021

    6 rounds

  40. Oct
    Invaio SciencesDebt · US$50MWith 1 other
  41. Sept
    Tarveda TherapeuticsVenture · US$6.0MWith 3 others
  42. Aug
    LarondeSeries B · US$440MWith 4 others
  43. Apr
    Repertoire Immune MedicinesSeries B$189MWith 3 others
  44. Mar
    Rubius Therapeutics$200MSole investor
  45. Feb
    Kaleido BioSciences$60MWith 2 others
  46. 2020

    1 round

  47. Dec
    Sigilon Therapeutics$145MWith 3 others

An announcement gives the size of the round, not the size of this investor's cheque: the only rounds that imply a cheque are those where they were the sole named investor.

The team

Named by the firm itself, on a filing, its Form ADV or its company registration1 named

NBNoubar B. Afeyan, Ph.D.CEO of the ManageriFiling they signed

We also hold 59 people at this firm from the lists this database was built from: a weaker source than the filings, since a list does not say when a title ended. Login to see them.

Who they invest alongside

The investors most often in the same rounds as Flagship Pioneering. A count of rooms they were both in, not a relationship either has claimed.

Recently backed

The latest companies Flagship Pioneering put money into.

On podcasts

3 episodes naming Flagship Pioneering in the title, and 3 more that mention it.

Mentioned in

Quick answers about Flagship Pioneering

What does Flagship Pioneering invest in?

Flagship Pioneering invests most often at Series A and Venture (53% of the rounds on record), in sectors such as Ehealth, Health-tech and Healthtech.

How active is Flagship Pioneering?

53 investments on record, 4 of them in the last 12 months. The most recent was in Apr 2026.

What has Flagship Pioneering invested in recently?

Its most recent investments on record: Metaphore Biotechnologies (Venture, Apr 2026), Serif Bio­med­i­cines (Venture, Apr 2026) and Foghorn Therapeutics (Undisclosed round, Jan 2026).

How big are Flagship Pioneering's cheques?

The median round it joins is $50M.

Does Flagship Pioneering lead rounds?

Rarely, if at all: none of its 53 investments on record names it as the lead.

Where does Flagship Pioneering invest?

Most of the companies it backs are in the United States (97%).

Is Flagship Pioneering investing now?

Yes: it is actively investing, with 4 investments in the last 12 months.

Who does Flagship Pioneering invest alongside?

Most often Invus (7 rounds together), Alexandria Venture Investments (6 rounds together) and Fidelity (6 rounds together).

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Built from the rounds we watched, its filings and its own website, refreshed every night. How we count · Report a correction · Is this your firm? Claim it