United States · Investor

ARCH Venture Partners

Last cheque observed Oct 2026; 337 cheques on record.

Deploying nowNew fund $2.8B, Aug 2026VC firm

SeedSeries ASeries BInformation TechnologyLife SciencesPhysical Sciences

Deploying now
84%of best year41cheques in 12 months, 337 on record
Since the last cheque11days00hrs00min00sec
Median round$74MCheque size, as they say$50K – $150MRounds led12 of 337Sole investor17 roundsExits19 from the portfolioMostly inUnited States, 92%
Pitch ARCH Venture Partners

ARCH Venture Partners highlights

  1. 01

    41 cheques in the last 12 months

  2. 02

    Mostly Series A and Series B: 61% of its rounds

  3. 03

    Sole investor in 17 rounds, median $18M

  4. 04

    19 exits from the portfolio

What they do

ARCH Venture Partners provides seed / early stage venture capital for technology firms in information technology, life sciences, and physical sciencesFrom their own website
Type
VC firm (from a list, unverified)
Cheque size
$50K – $150M as they say
Stages
SeedSeries ASeries BGrowth
Sectors
Information TechnologyLife SciencesPhysical Sciences
Based in
Chicago, United States
Cold pitches
Not stated

The record

Every round we can evidence, newest first337 appearances

  1. 2026

    31 rounds

  2. Oct
    Soufflé TherapeuticsSeries B · US · Google News search$135MWith 16 others
  3. Oct
    OratomicSeries B · US · Silicon Angle$475MLed
  4. Sept
    Encoded TherapeuticsSeries F · US$275MWith 4 others
  5. Sept
    Moonwalk BiosciencesSeries B · US$70MWith 4 others
  6. Sept
    RamonaSeries A · US$25MWith 2 others
  7. Jul
    OratomicSeries A · US · TechCrunch$300MLed
  8. Jul
    ErascaUS$633MWith 4 others
  9. Jun
    SonoTheraSeries B · US · Ventureburn$125MLed
  10. Jun
    PrometheusSeries B · US · TechCrunch$12BWith 7 others
  11. Jun
    City TherapeuticsSeries B · US · Ventureburn$100MWith 8 others
  12. Jun
    Parabilis MedicinesUS$75MWith 4 others
  13. Jun
    TraseSeed · US$107MWith 1 other
  14. Jun
    Ollin BiosciencesSeries B · US$330MWith 4 others
  15. May
    Countable LabsSeries A · Ventureburn$26MLed
  16. May
  17. May
    Sana BiotechnologyUS$69MWith 4 others
  18. Apr
    LightcastVenture · GB · Ventureburn$27MLed
  19. Apr
    MoleculentSeries A · SE$20MSole investor
  20. Apr
    Maze TherapeuticsUS$150MWith 5 others
  21. Mar
    Seaport TherapeuticsGrant · US$15MWith 2 others
  22. Mar
    Atlas Data StorageVenture · USUndisclosedWith 2 others
  23. Mar
    Scholar RockDebt · US$100MWith 3 others
  24. Feb
    Salma HealthSeries A · US$80MWith 1 other
  25. Feb
    Beam TherapeuticsDebt · US$100MWith 5 others
  26. Feb
    Syndex BioSeed · GB$16MSole investor
  27. Feb
    Vir BiotechnologyUS$150MWith 4 others
  28. Jan
    Just - Evotec BiologicsVenture · USUndisclosedWith 3 others
  29. Jan
    VizgenSeries E · US$48MWith 1 other
  30. Jan
    bit.bioSeries C$50MWith 5 others
  31. Jan
    Mirador TherapeuticsSeries B · US$250MWith 6 others
  32. Jan
    Parabilis MedicinesSeries F · US$305MWith 4 others
  33. 2025

    34 rounds

  34. Dec
    AledadeDebt · US$500MWith 4 others
  35. Dec
    Denali TherapeuticsDebt · US$200MWith 3 others
  36. Dec
    SciNeuroVenture · US$53MWith 3 others
  37. Dec
    ParadigmSeries B · US$78MWith 3 others
  38. Nov
    Aspen NeuroscienceSeries C · US · Ventureburn$115MLed
  39. Nov
    SynchronSeries D · US · Startup Daily$305MWith 13 others
  40. Nov
    Sonoma BiotherapeuticsGrant · US$300KWith 4 others
  41. Nov
    Lifordi ImmunotherapeuticsVenture · US$42MWith 3 others
  42. Nov
    Gate BioscienceSeries B · US$65MWith 5 others

An announcement gives the size of the round, not the size of this investor's cheque: the only rounds that imply a cheque are those where they were the sole named investor.

The team

Named by the firm itself, on a filing, its Form ADV or its company registration9 named

CWClinton Whitewood BybeeManaging Director of the General Partner.iFiling they signed
JLJason L. DorenGeneral Counsel of the GP LLCiFiling they signed
KLKeith Lawrence CrandellManaging Director, President, Secretary and ShareholderiForm ADV
KMKristina Marie BurowManaging Director, Vice President, and ShareholderiForm ADV
MAMark Andrew McdonnellManaging Director of the General Partner.iFiling they signed
PTPaul T. BernsManaging Director of the GP LLCiFiling they signed
PTPaul T. ThurkManaging Director of the General Partner.iFiling they signed
RTRobert Taylor NelsenManaging Director of the General Partner.iFiling they signed
SLSteven L. GillisManaging Director of the General PartneriFiling they signed

We also hold 56 people at this firm from the lists this database was built from: a weaker source than the filings, since a list does not say when a title ended. Login to see them.

What the register says

From the firm's own filings with the SEC, which it must file accurately by law

$11Bgross assets of its fundsOct 2026
Exemptreporting adviserventure or small private funds
Legal name
ARCH Venture Management LLC
SEC number
CRD 158196

Who backs their funds

1 LP on record in ARCH Venture Partners's funds

Committed
$30M
Funds
1
Vintages
2004

The institutions that put money into its funds, which the firm then invests in companies.Source: the pension's own report, latest Jun 2025.

What they claim to have backed

Weaker than a round we watched, stronger than a list somebody sold us. A firm is far less willing to put a company on its own site that it never funded.

Exits from the portfolio

Companies it backed that were later bought or listed19 in all

ReceptosBought by Celgene$7.3BJul 2015
Kythera BiopharmaceuticalsBought by Allergan$2.1BJun 2015
IkariaBought by Mallinckrodt$2.3BMar 2015
NitronexBought by M/A-COM Technology Solutions$26MFeb 2014
KOTURABought by Mellanox Technologies$82MAug 2013
bluebird bioListed$101MJun 2013
Agios PharmaceuticalsListed$86MJun 2013
InnovalightBought by DuPontUndisclosedJul 2011
Surface LogixBought by Nano TerraUndisclosedApr 2011
OmerosListedUndisclosedOct 2009
Amphora DiscoveryBought by NanosynUndisclosedJul 2008
Univa UDBought by Univa UDUndisclosedOct 2007
Vascular ArchitectsBought by LeMaitre VascularUndisclosedSept 2007
NeurogesXListedUndisclosedFeb 2007
SilverStorm TechnologiesBought by QLogicUndisclosedOct 2006
NexCuraBought by The Thompson CorporationUndisclosedNov 2005
Teach.comBought by IntellinexUndisclosedOct 2000

An exit counts when it came after the firm's first round in the company. From historical deal records.

Who they invest alongside

The investors most often in the same rounds as ARCH Venture Partners. A count of rooms they were both in, not a relationship either has claimed.

Recently backed

The latest companies ARCH Venture Partners put money into.

Mentioned on podcasts

Episodes that name ARCH Venture Partners in their description, not their title.

Quick answers about ARCH Venture Partners

What does ARCH Venture Partners invest in?

ARCH Venture Partners invests most often at Series A and Series B (61% of the rounds on record), in sectors such as Information Technology, Life Sciences and Physical Sciences.

How active is ARCH Venture Partners?

337 investments on record, 41 of them in the last 12 months, and it led 12. The most recent was in Oct 2026.

What has ARCH Venture Partners invested in recently?

Its most recent investments on record: Soufflé Therapeutics (Series B, Oct 2026), Oratomic (Series B, Oct 2026) and Encoded Therapeutics (Series F, Sept 2026).

How big are ARCH Venture Partners's cheques?

The median round it joins is $74M. It says it writes cheques of $50K to $150M.

Does ARCH Venture Partners lead rounds?

Sometimes: it led 12 of its 337 investments on record (4%).

Where does ARCH Venture Partners invest?

Most of the companies it backs are in the United States (92%) and the United Kingdom (5%).

Is ARCH Venture Partners investing now?

Yes: it is actively investing, with 41 investments in the last 12 months.

Who does ARCH Venture Partners invest alongside?

Most often Polaris Partners (34 rounds together), Venrock (27 rounds together) and Fidelity (24 rounds together).

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Built from the rounds we watched, its filings and its own website, refreshed every night. How we count · Report a correction · Is this your firm? Claim it