Top list · Waltham
Biotech startups in Waltham
37 biotech startups in Waltham have raised money in rounds we track. These are the 37 that have raised the most, $5.6B between them.
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Oruka TherapeuticsOruka Therapeutics is advancing innovative biologics to redefine patient care standards in chronic skin diseases.Oruka Therapeutics is advancing innovative biologics to redefine patient care standards in chronic skin diseases.
Founded -Waltham, United States$880Mlast round Apr 2026 - 2
Dyne TherapeuticsDyne Therapeutics is a developer of targeted therapies intended for serious muscle diseases.Dyne Therapeutics is a developer of targeted therapies intended for serious muscle diseases.
Founded 2018Waltham, United States$828Mlast round Jul 2026 - 3
Kailera TherapeuticsKailera Therapeutics develops next-generation injectable and oral therapies for chronic weight management.Kailera Therapeutics develops next-generation injectable and oral therapies for chronic weight management.
Founded -Waltham, United States$600Mlast round Oct 2025 - 4
ElevateBioElevateBio is a biotechnology company based in Waltham, Massachusetts, founded in 2017.ElevateBio is a biotechnology company based in Waltham, Massachusetts, founded in 2017.
Founded 2017Waltham, United States$551Mlast round May 2023 - 5
Zenas BioPharmaZenas BioPharma is a biopharmaceutical company that focuses on developing immune-based therapies for patients.Zenas BioPharma is a biopharmaceutical company that focuses on developing immune-based therapies for patients.
Founded 2023Waltham, United States$420Mlast round Mar 2026 - 6
Morphic TherapeuticMorphic Therapeutic is a biotechnology company that develops oral integrin therapies to treat serious chronic diseases.Morphic Therapeutic is a biotechnology company that develops oral integrin therapies to treat serious chronic diseases.
Founded 2015Waltham, United States$328Mlast round May 2023 - 7
Upstream BioUpstream Bio focuses on developing an antibody therapy for the treatment of severe asthma.Upstream Bio focuses on developing an antibody therapy for the treatment of severe asthma.
Founded 2021Waltham, United States$200Mlast round Jun 2023 - 8
BostonGeneBostonGene is a biotechnology company based in Waltham, Massachusetts, founded in 2015.BostonGene is a biotechnology company based in Waltham, Massachusetts, founded in 2015.
Founded 2015Waltham, United States$200Mlast round Apr 2022 - 9
Cogent BiosciencesCogent Biosciences is a biotechnology company that develops therapies for solid cancer tumors.Cogent Biosciences is a biotechnology company that develops therapies for solid cancer tumors.
Founded 2014Waltham, United States$200Mlast round Nov 2025 - 10
Skyhawk TherapeuticsSkyhawk Therapeutics is a clinical-stage biotechnology company located in Waltham, Massachusetts.Skyhawk Therapeutics is a clinical-stage biotechnology company located in Waltham, Massachusetts.
Founded 2016Waltham, United States$133Mlast round Sept 2021 - 11
Deciphera PharmaceuticalsDeciphera Pharmaceuticals focuses on improving kinase inhibitor treatments.Deciphera Pharmaceuticals focuses on improving kinase inhibitor treatments.
Founded 2003Waltham, United States$127Mlast round Jun 2017 - 12
InvivydInvivyd develops antibodies to transcend the limitations of the human immune system and fight against viral infections.Invivyd develops antibodies to transcend the limitations of the human immune system and fight against viral infections.
Founded 2020Waltham, United States$125Mlast round Nov 2025 - 13
VisterraVisterra researches on and develops therapeutic and diagnostic products for the treatment of infectious diseases.Visterra researches on and develops therapeutic and diagnostic products for the treatment of infectious diseases.
Founded 2007Waltham, United States$120Mlast round Oct 2017 - 14
Palleon PharmaceuticalsPalleon Pharmaceuticals is a clinical-stage biotechnology company based in Waltham, Massachusetts.Palleon Pharmaceuticals is a clinical-stage biotechnology company based in Waltham, Massachusetts.
Founded 2016Waltham, United States$100Mlast round Sept 2020 - 15
TScan TherapeuticsTScan Therapeutics is a biopharmaceutical company focused on the development of immunotherapy treatments for cancer.TScan Therapeutics is a biopharmaceutical company focused on the development of immunotherapy treatments for cancer.
Founded 2018Waltham, United States$78Mlast round Dec 2024 - 16
Exosome DiagnosticsExosome Diagnostics develops and commercializes blood-based cancer molecular diagnostics for patient stratification and disease monitoring.Exosome Diagnostics develops and commercializes blood-based cancer molecular diagnostics for patient stratification and disease monitoring.
Founded 2008Waltham, United States$76Mlast round Sept 2015 - 17
Photys TherapeuticsPhotys Therapeutics is a biotechnology and pharmaceutical research company founded in 2021 and based in Waltham, Massachusetts.Photys Therapeutics is a biotechnology and pharmaceutical research company founded in 2021 and based in Waltham, Massachusetts.
Founded 2021Waltham, United States$75Mlast round Sept 2022 - 18
EloxxEloxx Pharmaceuticals is a clinical-stage biopharmaceutical company developing novel RNA-modulating drug candidates.Eloxx Pharmaceuticals is a clinical-stage biopharmaceutical company developing novel RNA-modulating drug candidates.
Founded 2013Waltham, United States$66Mlast round Jun 2026 - 19
Orionis BiosciencesOrionis Biosciences is a clinical-stage life sciences company based in Waltham, Massachusetts, with a research facility in Ghent, Belgium.Orionis Biosciences is a clinical-stage life sciences company based in Waltham, Massachusetts, with a research facility in Ghent, Belgium.
Founded 2015Waltham, United States$59Mlast round Oct 2022 - 20
Immunitas TherapeuticsImmunitas Therapeutics is a clinical-stage biopharmaceutical company founded in 2019, focused on discovering and developing novel antibody-based therapeutics foImmunitas Therapeutics is a clinical-stage biopharmaceutical company founded in 2019, focused on discovering and developing novel antibody-based therapeutics fo
Founded 2019Waltham, United States$58Mlast round Aug 2021 - 21
InstyllaInstylla is a medical equipment supplier that provides liquid embolics of the next generation for interventional radiology.Instylla is a medical equipment supplier that provides liquid embolics of the next generation for interventional radiology.
Founded 2017Waltham, United States$56Mlast round Jul 2026 - 22
Convergent DentalConvergent Dental develops a computer-guided, laser-based drilling, and cutting system for dentists.Convergent Dental develops a computer-guided, laser-based drilling, and cutting system for dentists.
Founded 2011Waltham, United States$52Mlast round Apr 2023 - 23SojournixSojournix is a clinical-stage pharmaceutical company that researches and develops novel therapeutics for the treatment of neuroendocrine disorders.
Sojournix is a clinical-stage pharmaceutical company that researches and develops novel therapeutics for the treatment of neuroendocrine disorders.
Founded 2016Waltham, United States$44Mlast round Jan 2019 - 24
NanoMosaicNanoMosaic provides solutions for early illness detection, prognostic monitoring, and biomarker identification.NanoMosaic provides solutions for early illness detection, prognostic monitoring, and biomarker identification.
Founded 2018Waltham, United States$44Mlast round Nov 2025 - 25
Affinia TherapeuticsAffinia Therapeutics is a preclinical-stage biotechnology company based in Waltham, Massachusetts, founded in 2019.Affinia Therapeutics is a preclinical-stage biotechnology company based in Waltham, Massachusetts, founded in 2019.
Founded 2019Waltham, United States$40Mlast round Oct 2025 - 26Pyramid BiosciencesPyramid Biosciences is a clinical-stage biotechnology company based in New Jersey, founded in 2015.
Pyramid Biosciences is a clinical-stage biotechnology company based in New Jersey, founded in 2015.
Founded 2015Waltham, United States$34Mlast round Oct 2021 - 27
Vicarious SurgicalVicarious Surgical is a robotics company that develops robotic systems that allow surgeons to perform minimally invasive surgery.Vicarious Surgical is a robotics company that develops robotic systems that allow surgeons to perform minimally invasive surgery.
Founded 2014Waltham, United States$33Mlast round Oct 2025 - 28
Avilar TherapeuticsAvilar Therapeutics is a biopharmaceutical company based in Waltham, Massachusetts, founded in 2020.Avilar Therapeutics is a biopharmaceutical company based in Waltham, Massachusetts, founded in 2020.
Founded 2020Waltham, United States$15Mlast round Feb 2023 - 29
Fortitude BiomedicinesFortitude Biomedicines, Inc.Fortitude Biomedicines, Inc.
Founded 2025Waltham, United States$13Mlast round Jan 2026 - 30
Lucy TherapeuticsLucy Therapeutics is a private biotechnology company based in Waltham, Massachusetts, founded in 2017.Lucy Therapeutics is a private biotechnology company based in Waltham, Massachusetts, founded in 2017.
Founded 2017Waltham, United States$13Mlast round May 2024 - 31NKT TherapeuticsNKT Therapeutics is a privately held biotechnology company focused on developing therapeutics to treat cancer and other serious diseases.
NKT Therapeutics is a privately held biotechnology company focused on developing therapeutics to treat cancer and other serious diseases.
Founded 2008Waltham, United States$12Mlast round Aug 2010 - 32
ENSEM TherapeuticsEnsem Therapeutics is a biopharmaceutical company based in Waltham, Massachusetts, focused on developing innovative small-molecule precision medicines for oncology.Ensem Therapeutics is a biopharmaceutical company based in Waltham, Massachusetts, focused on developing innovative small-molecule precision medicines for oncology.
Founded 2021Waltham, United States$10Mlast round Oct 2023 - 33
Bonito BiosciencesBonito Biosciences is a biotechnology research firm specializing in tissue-selective drug delivery for oligonucleotides and macromolecules.Bonito Biosciences is a biotechnology research firm specializing in tissue-selective drug delivery for oligonucleotides and macromolecules.
Founded -Waltham, United States$9.0Mlast round May 2024 - 34
Minerva BiotechnologiesMinerva Biotechnologies develops cancer immunotherapies and cancer drugs to target 80% of solid tumors and to prevent cancer metastasis.Minerva Biotechnologies develops cancer immunotherapies and cancer drugs to target 80% of solid tumors and to prevent cancer metastasis.
Founded 1999Waltham, United States$8.2Mlast round Oct 2014 - 35
Amagma TherapeuticsAmagma is a biotechnology company that develops and commercializes antibody therapeutics for the treatment of inflammatory diseases.Amagma is a biotechnology company that develops and commercializes antibody therapeutics for the treatment of inflammatory diseases.
Founded 2019Waltham, United States$2.3Mlast round Jun 2022 - 36
Paragonix TechnologiesParagonix Technologies is a medical device company specialized in organ preservation devices for the improvement of donor organ quality.Paragonix Technologies is a medical device company specialized in organ preservation devices for the improvement of donor organ quality.
Founded 2010Waltham, United States$1.1Mlast round Dec 2013 - 37
Ventus TherapeuticsVentus Therapeutics develops small molecule drugs that target autoimmune diseases, inflammatory diseases, and cancer.Ventus Therapeutics develops small molecule drugs that target autoimmune diseases, inflammatory diseases, and cancer.
Founded 2019Waltham, United States$150Klast round Apr 2023
Waltham, United StatesCompanies whose funding rounds we classed in this sector, ranked by the total they have raised in rounds we hold. Nobody pays to be on a list.
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