Top list · Waltham
Startups in Waltham
106 startups in Waltham have raised money in rounds we track. These are the 50 that have raised the most, $12B between them.
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Devoted HealthDevoted Health is a technology-driven healthcare company founded in 2017 by brothers Todd and Ed Park.Devoted Health is a technology-driven healthcare company founded in 2017 by brothers Todd and Ed Park.
Founded 2017Waltham, United States$2.1Blast round Nov 2026 - 2
Oruka TherapeuticsOruka Therapeutics is advancing innovative biologics to redefine patient care standards in chronic skin diseases.Oruka Therapeutics is advancing innovative biologics to redefine patient care standards in chronic skin diseases.
Founded -Waltham, United States$880Mlast round Apr 2026 - 3
Dyne TherapeuticsDyne Therapeutics is a developer of targeted therapies intended for serious muscle diseases.Dyne Therapeutics is a developer of targeted therapies intended for serious muscle diseases.
Founded 2018Waltham, United States$828Mlast round Jul 2026 - 4
Dianthus TherapeuticsDianthus Therapeutics is a biotech company developing new treatments for serious autoimmune diseases using a more targeted approach.Dianthus Therapeutics is a biotech company developing new treatments for serious autoimmune diseases using a more targeted approach.
Founded 2019Waltham, United States$719Mlast round Mar 2026 - 5
Next InsuranceNext Insurance is a digital insurance company specializing in coverage for entrepreneurs and small businesses.Next Insurance is a digital insurance company specializing in coverage for entrepreneurs and small businesses.
Founded 2016Waltham, United States$627Mlast round Nov 2023 - 6
Kailera TherapeuticsKailera Therapeutics develops next-generation injectable and oral therapies for chronic weight management.Kailera Therapeutics develops next-generation injectable and oral therapies for chronic weight management.
Founded -Waltham, United States$600Mlast round Oct 2025 - 7
ElevateBioElevateBio is a biotechnology company based in Waltham, Massachusetts, founded in 2017.ElevateBio is a biotechnology company based in Waltham, Massachusetts, founded in 2017.
Founded 2017Waltham, United States$551Mlast round May 2023 - 8
Korsana BiosciencesKorsana Biosciences develops THETA-enabled antibody therapies for neurodegenerative diseases including Alzheimer’s.Korsana Biosciences develops THETA-enabled antibody therapies for neurodegenerative diseases including Alzheimer’s.
Founded -Waltham, United States$530Mlast round Sept 2026 - 9
Zenas BioPharmaZenas BioPharma is a biopharmaceutical company that focuses on developing immune-based therapies for patients.Zenas BioPharma is a biopharmaceutical company that focuses on developing immune-based therapies for patients.
Founded 2023Waltham, United States$420Mlast round Mar 2026 - 10
Morphic TherapeuticMorphic Therapeutic is a biotechnology company that develops oral integrin therapies to treat serious chronic diseases.Morphic Therapeutic is a biotechnology company that develops oral integrin therapies to treat serious chronic diseases.
Founded 2015Waltham, United States$328Mlast round May 2023 - 11
MarkforgedMarkforged is a manufacturing company that invents a new 3D printing process to build parts with the strength of Continuous Carbon Fiber.Markforged is a manufacturing company that invents a new 3D printing process to build parts with the strength of Continuous Carbon Fiber.
Founded 2013Waltham, United States$323Mlast round Jul 2021 - 12
ActifioActifio delivers enterprise data-as-a-service to global enterprise customers and service provider partners.Actifio delivers enterprise data-as-a-service to global enterprise customers and service provider partners.
Founded 2009Waltham, United States$308Mlast round Aug 2018 - 13
Upstream BioUpstream Bio focuses on developing an antibody therapy for the treatment of severe asthma.Upstream Bio focuses on developing an antibody therapy for the treatment of severe asthma.
Founded 2021Waltham, United States$200Mlast round Jun 2023 - 14
BostonGeneBostonGene is a biotechnology company based in Waltham, Massachusetts, founded in 2015.BostonGene is a biotechnology company based in Waltham, Massachusetts, founded in 2015.
Founded 2015Waltham, United States$200Mlast round Apr 2022 - 15
Cogent BiosciencesCogent Biosciences is a biotechnology company that develops therapies for solid cancer tumors.Cogent Biosciences is a biotechnology company that develops therapies for solid cancer tumors.
Founded 2014Waltham, United States$200Mlast round Nov 2025 - 16
Jade BiosciencesJade Biosciences is developing transformative therapies to redefine the standard of care for inflammation and immunology indications.Jade Biosciences is developing transformative therapies to redefine the standard of care for inflammation and immunology indications.
Founded -Waltham, United States$195Mlast round Jun 2026 - 17
CallMinerCallMiner provides solutions for analyzing and extracting insights from customer interactions, particularly in call centers.CallMiner provides solutions for analyzing and extracting insights from customer interactions, particularly in call centers.
Founded 2002Waltham, United States$155Mlast round Jun 2025 - 18
Skyhawk TherapeuticsSkyhawk Therapeutics is a clinical-stage biotechnology company located in Waltham, Massachusetts.Skyhawk Therapeutics is a clinical-stage biotechnology company located in Waltham, Massachusetts.
Founded 2016Waltham, United States$133Mlast round Sept 2021 - 19
Deciphera PharmaceuticalsDeciphera Pharmaceuticals focuses on improving kinase inhibitor treatments.Deciphera Pharmaceuticals focuses on improving kinase inhibitor treatments.
Founded 2003Waltham, United States$127Mlast round Jun 2017 - 20
InvivydInvivyd develops antibodies to transcend the limitations of the human immune system and fight against viral infections.Invivyd develops antibodies to transcend the limitations of the human immune system and fight against viral infections.
Founded 2020Waltham, United States$125Mlast round Nov 2025 - 21
VisterraVisterra researches on and develops therapeutic and diagnostic products for the treatment of infectious diseases.Visterra researches on and develops therapeutic and diagnostic products for the treatment of infectious diseases.
Founded 2007Waltham, United States$120Mlast round Oct 2017 - 22
Scipher MedicineScipher Medicine develops a healthcare platform designed to determine which drug will work best for each patient.Scipher Medicine develops a healthcare platform designed to determine which drug will work best for each patient.
Founded 2014Waltham, United States$110Mlast round Feb 2022 - 23
KouraKoura is a global leader in the development, manufacture, and supply of fluoro products.Koura is a global leader in the development, manufacture, and supply of fluoro products.
Founded 2011Waltham, United States$100Mlast round Oct 2022 - 24
Palleon PharmaceuticalsPalleon Pharmaceuticals is a clinical-stage biotechnology company based in Waltham, Massachusetts.Palleon Pharmaceuticals is a clinical-stage biotechnology company based in Waltham, Massachusetts.
Founded 2016Waltham, United States$100Mlast round Sept 2020 - 25
CounterTackCounterTack is a cybersecurity company based in Waltham, Massachusetts, with additional offices in California and Singapore.CounterTack is a cybersecurity company based in Waltham, Massachusetts, with additional offices in California and Singapore.
Founded 2011Waltham, United States$97Mlast round May 2017 - 26
InfinidatInfinidat's portfolio of primary and secondary storage platforms provides best-in-class performance with guaranteed 100% availability, built in InfiniSafe®️ cybInfinidat's portfolio of primary and secondary storage platforms provides best-in-class performance with guaranteed 100% availability, built in InfiniSafe®️ cyb
Founded 2011Waltham, United States$95Mlast round Oct 2017 - 27
Evolv TechnologyEvolv Technology an AI-enabled touchless security screening system that uses digital sensors and artificial intelligence to detect threats.Evolv Technology an AI-enabled touchless security screening system that uses digital sensors and artificial intelligence to detect threats.
Founded 2013Waltham, United States$93Mlast round Jul 2025 - 28
Rocket SoftwareRocket Software is a software development firm that offers enterprise infrastructure products and various related services.Rocket Software is a software development firm that offers enterprise infrastructure products and various related services.
Founded 1990Waltham, United States$92Mlast round Oct 2009 - 29Artisan PharmaArtisan Pharma is a Hospital and Health Care company located in 230 Third Avenue, Waltham, MA, United States.
Artisan Pharma is a Hospital and Health Care company located in 230 Third Avenue, Waltham, MA, United States.
Founded 2006Waltham, United States$85Mlast round Jul 2010 - 30
IncipientIncipient software allows for: * Non-Disruptive, On-Line Data Migration * Network Volume Management * Storage Provisioning * Copy Services With Incipient softwaIncipient software allows for: * Non-Disruptive, On-Line Data Migration * Network Volume Management * Storage Provisioning * Copy Services With Incipient softwa
Founded 2001Waltham, United States$85Mlast round Feb 2008 - 31
TScan TherapeuticsTScan Therapeutics is a biopharmaceutical company focused on the development of immunotherapy treatments for cancer.TScan Therapeutics is a biopharmaceutical company focused on the development of immunotherapy treatments for cancer.
Founded 2018Waltham, United States$78Mlast round Dec 2024 - 32
Exosome DiagnosticsExosome Diagnostics develops and commercializes blood-based cancer molecular diagnostics for patient stratification and disease monitoring.Exosome Diagnostics develops and commercializes blood-based cancer molecular diagnostics for patient stratification and disease monitoring.
Founded 2008Waltham, United States$76Mlast round Sept 2015 - 33
Photys TherapeuticsPhotys Therapeutics is a biotechnology and pharmaceutical research company founded in 2021 and based in Waltham, Massachusetts.Photys Therapeutics is a biotechnology and pharmaceutical research company founded in 2021 and based in Waltham, Massachusetts.
Founded 2021Waltham, United States$75Mlast round Sept 2022 - 34
EloxxEloxx Pharmaceuticals is a clinical-stage biopharmaceutical company developing novel RNA-modulating drug candidates.Eloxx Pharmaceuticals is a clinical-stage biopharmaceutical company developing novel RNA-modulating drug candidates.
Founded 2013Waltham, United States$66Mlast round Jun 2026 - 35
YottaaYottaa is a cloud-based eCommerce performance and security company based in Waltham, Massachusetts.Yottaa is a cloud-based eCommerce performance and security company based in Waltham, Massachusetts.
Founded 2009Waltham, United States$63Mlast round Oct 2018 - 36
Orionis BiosciencesOrionis Biosciences is a clinical-stage life sciences company based in Waltham, Massachusetts, with a research facility in Ghent, Belgium.Orionis Biosciences is a clinical-stage life sciences company based in Waltham, Massachusetts, with a research facility in Ghent, Belgium.
Founded 2015Waltham, United States$59Mlast round Oct 2022 - 37
Immunitas TherapeuticsImmunitas Therapeutics is a clinical-stage biopharmaceutical company founded in 2019, focused on discovering and developing novel antibody-based therapeutics foImmunitas Therapeutics is a clinical-stage biopharmaceutical company founded in 2019, focused on discovering and developing novel antibody-based therapeutics fo
Founded 2019Waltham, United States$58Mlast round Aug 2021 - 38
InstyllaInstylla is a medical equipment supplier that provides liquid embolics of the next generation for interventional radiology.Instylla is a medical equipment supplier that provides liquid embolics of the next generation for interventional radiology.
Founded 2017Waltham, United States$56Mlast round Jul 2026 - 39
Linus HealthLinus Health is a digital health company focused on improving mental health and brain health by using screening technology.Linus Health is a digital health company focused on improving mental health and brain health by using screening technology.
Founded 2019Waltham, United States$55Mlast round Jul 2021 - 40
Convergent DentalConvergent Dental develops a computer-guided, laser-based drilling, and cutting system for dentists.Convergent Dental develops a computer-guided, laser-based drilling, and cutting system for dentists.
Founded 2011Waltham, United States$52Mlast round Apr 2023 - 41
Great Elm CapitalGreat Elm Capital is a business development company that invests in the debt instruments of middle-market companies.Great Elm Capital is a business development company that invests in the debt instruments of middle-market companies.
Founded -Waltham, United States$50Mlast round Sept 2025 - 42
HumaticsHumatics is a technology company based in Waltham, Massachusetts, founded in 2015.Humatics is a technology company based in Waltham, Massachusetts, founded in 2015.
Founded 2015Waltham, United States$46Mlast round Jun 2023 - 43
Vecna RoboticsVecna Robotics, Inc.Vecna Robotics, Inc.
Founded 1998Waltham, United States$46Mlast round Sept 2026 - 44SojournixSojournix is a clinical-stage pharmaceutical company that researches and develops novel therapeutics for the treatment of neuroendocrine disorders.
Sojournix is a clinical-stage pharmaceutical company that researches and develops novel therapeutics for the treatment of neuroendocrine disorders.
Founded 2016Waltham, United States$44Mlast round Jan 2019 - 45
NanoMosaicNanoMosaic provides solutions for early illness detection, prognostic monitoring, and biomarker identification.NanoMosaic provides solutions for early illness detection, prognostic monitoring, and biomarker identification.
Founded 2018Waltham, United States$44Mlast round Nov 2025 - 46
Xilio TherapeuticsXilio Therapeutics is a biotechnology company that develops tumor-activated immuno-oncology therapies.Xilio Therapeutics is a biotechnology company that develops tumor-activated immuno-oncology therapies.
Founded 2020Waltham, United States$40Mlast round Feb 2026 - 47
Affinia TherapeuticsAffinia Therapeutics is a preclinical-stage biotechnology company based in Waltham, Massachusetts, founded in 2019.Affinia Therapeutics is a preclinical-stage biotechnology company based in Waltham, Massachusetts, founded in 2019.
Founded 2019Waltham, United States$40Mlast round Oct 2025 - 48CazenaCazena, Inc is a Massachusetts based company delivering fully-managed Big Data as a Service
Cazena, Inc is a Massachusetts based company delivering fully-managed Big Data as a Service
Founded 2014Waltham, United States$38Mlast round Jul 2020 - 49
Boston DynamicsBoston Dynamics builds advanced mobile manipulation robots with remarkable mobility, dexterity perception and agility.Boston Dynamics builds advanced mobile manipulation robots with remarkable mobility, dexterity perception and agility.
Founded 1992Waltham, United States$37Mlast round Feb 2019 - 50
AugmenixSpaceOAR designs, develops and commercializes hydrogel based medical devices for radiation oncology, urology and cancer surgery.SpaceOAR designs, develops and commercializes hydrogel based medical devices for radiation oncology, urology and cancer surgery.
Founded 2007Waltham, United States$36Mlast round Jul 2014
Waltham, United StatesEvery startup we hold in Waltham, ranked by the total it has raised in rounds we hold. Nobody pays to be on a list.
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