Top list · San Francisco

B2B startups in San Francisco

63 B2B startups in San Francisco have raised money in rounds we track. These are the 50 that have raised the most, $1.2B between them.

$1.2Braised by these 50
63on our record in all
Twist Bioscienceraised the most
  1. 1Twist BioscienceTwist Bioscience is a biotechnology company that offers synthetic DNA solutions, gene synthesis, and variant libraries.

    Twist Bioscience is a biotechnology company that offers synthetic DNA solutions, gene synthesis, and variant libraries.

    Founded 2013San Francisco, United States$332Mlast round Feb 2022
  2. 2LassieWe're building the operating system for independent doctors.

    We're building the operating system for independent doctors.

    Founded -San Francisco, United States$135Mlast round Jun 2026
  3. 3SendosoSendoso is a leading B2B corporate gifting and direct mail platform, founded in 2016 and based in San Francisco, California.

    Sendoso is a leading B2B corporate gifting and direct mail platform, founded in 2016 and based in San Francisco, California.

    Founded 2016San Francisco, United States$111Mlast round Sept 2021
  4. 4ParafinGrowing small businesses through embedded financial services enabled on the very platforms on which SMBs sell & transact

    Growing small businesses through embedded financial services enabled on the very platforms on which SMBs sell & transact

    Founded 2020San Francisco, United States$100Mlast round May 2026
  5. 5SideGuideBuilding developer experience tools of the future

    Building developer experience tools of the future

    Founded 2022San Francisco, United States$83Mlast round Sept 2026
  6. 6MURALMural is an AI-powered visual workspace platform that enhances team collaboration by connecting strategy to execution in a shared digital environment.

    Mural is an AI-powered visual workspace platform that enhances team collaboration by connecting strategy to execution in a shared digital environment.

    Founded 2011San Francisco, United States$67Mlast round Oct 2026
  7. 7BravadoBravado is a global music merchandise and brand management company, operating as a subsidiary of Universal Music Group.

    Bravado is a global music merchandise and brand management company, operating as a subsidiary of Universal Music Group.

    Founded 2017San Francisco, United States$38Mlast round May 2022
  8. 8DemostackDemostack is a cloud-based demo experience platform founded in 2020, headquartered in San Francisco, California.

    Demostack is a cloud-based demo experience platform founded in 2020, headquartered in San Francisco, California.

    Founded 2020San Francisco, United States$34Mlast round Apr 2022
  9. 9UpCounselUpCounsel is a San Francisco-based online marketplace for legal services, founded in 2012.

    UpCounsel is a San Francisco-based online marketplace for legal services, founded in 2012.

    Founded 2012San Francisco, United States$30Mlast round Dec 2021
  10. 10RattleRattle Software Inc.

    Rattle Software Inc.

    Founded 2020San Francisco, United States$26Mlast round Apr 2022
  11. 11TrendsiTrendsi is a B2B dropshipping platform that specializes in fashion, allowing businesses to sell clothing and jewelry without the need to hold inventory.

    Trendsi is a B2B dropshipping platform that specializes in fashion, allowing businesses to sell clothing and jewelry without the need to hold inventory.

    Founded 2020San Francisco, United States$25Mlast round Oct 2022
  12. 12RecurrencyRecurrency is a technology company based in San Francisco that specializes in ERP (Enterprise Resource Planning) automation for growing wholesale distributors a

    Recurrency is a technology company based in San Francisco that specializes in ERP (Enterprise Resource Planning) automation for growing wholesale distributors a

    Founded 2019San Francisco, United States$22Mlast round Feb 2023
  13. 13PushPressPushPress is a gym management software company founded in 2011, designed specifically for independent fitness businesses.

    PushPress is a gym management software company founded in 2011, designed specifically for independent fitness businesses.

    Founded 2011San Francisco, United States$20Mlast round Oct 2024
  14. 14UiflowUiflow is a no-code platform that allows enterprises to quickly build production-ready applications without extensive coding.

    Uiflow is a no-code platform that allows enterprises to quickly build production-ready applications without extensive coding.

    Founded 2020San Francisco, United States$15Mlast round Sept 2022
  15. 15SugerSuger is an API-first Software-as-a-Service (SaaS) platform that helps B2B software companies streamline their Cloud Go-to-Market (Cloud GTM) strategies.

    Suger is an API-first Software-as-a-Service (SaaS) platform that helps B2B software companies streamline their Cloud Go-to-Market (Cloud GTM) strategies.

    Founded 2022San Francisco, United States$15Mlast round Feb 2025
  16. 16JigaJiga is an AI-powered sourcing platform founded in 2020 that connects engineers directly with vetted manufacturers.

    Jiga is an AI-powered sourcing platform founded in 2020 that connects engineers directly with vetted manufacturers.

    Founded 2020San Francisco, United States$12Mlast round Nov 2025
  17. 17TriangleTriangle is a software company that builds web3 wallet infrastructure for defi, NFTs, payments, social, and gaming.

    Triangle is a software company that builds web3 wallet infrastructure for defi, NFTs, payments, social, and gaming.

    Founded 2022San Francisco, United States$12Mlast round Aug 2026
  18. 18OutbuildOutbuild is a construction technology company based in San Francisco, founded in 2021.

    Outbuild is a construction technology company based in San Francisco, founded in 2021.

    Founded 2021San Francisco, United States$11Mlast round Nov 2024
  19. 19Wheel the WorldWheel the World is a technology-enabled travel platform dedicated to making travel accessible for individuals with disabilities, seniors, and their companions.

    Wheel the World is a technology-enabled travel platform dedicated to making travel accessible for individuals with disabilities, seniors, and their companions.

    Founded 2018San Francisco, United States$11Mlast round Feb 2026
  20. 20ChangeEngineChangeEngine is a San Francisco-based SaaS technology company founded in September 2021.

    ChangeEngine is a San Francisco-based SaaS technology company founded in September 2021.

    Founded 2021San Francisco, United States$10Mlast round May 2024
  21. 21FoundationFoundation, Inc.

    Foundation, Inc.

    Founded 2023San Francisco, United States$9.4Mlast round May 2026
  22. 22ZeroPathZeroPath is an AI-native application security platform founded in 2024 by former security engineers from Tesla and Google.

    ZeroPath is an AI-native application security platform founded in 2024 by former security engineers from Tesla and Google.

    Founded 2024San Francisco, United States$5.0Mlast round Sept 2025
  23. 23ByteboardByteboard redesigns technical interviews to be more reflective of what engineers do on the job through.

    Byteboard redesigns technical interviews to be more reflective of what engineers do on the job through.

    Founded 2018San Francisco, United States$5.0Mlast round Jan 2022
  24. 24Enable UsEnable Us is the most versatile buyer-centric enablement platform built to make the buying experience more efficient, transparent & personal

    Enable Us is the most versatile buyer-centric enablement platform built to make the buying experience more efficient, transparent & personal

    Founded 2020San Francisco, United States$4.5Mlast round Dec 2021
  25. 25ResponseResponse is a technology-driven company based in San Francisco, California, specializing in procurement management, indirect spend control, and supply chain optimization.

    Response is a technology-driven company based in San Francisco, California, specializing in procurement management, indirect spend control, and supply chain optimization.

    Founded 2019San Francisco, United States$4.2Mlast round Feb 2025
  26. 26AlgunaAlguna is an AI-native revenue management platform founded in 2023 and headquartered in San Francisco.

    Alguna is an AI-native revenue management platform founded in 2023 and headquartered in San Francisco.

    Founded 2023San Francisco, United States$4.0Mlast round Sept 2025
  27. 27PartnerSlatePartnerSlate is a B2B marketplace and discovery platform tailored for consumer packaged goods (CPG) companies, particularly in the food and beverage sector.

    PartnerSlate is a B2B marketplace and discovery platform tailored for consumer packaged goods (CPG) companies, particularly in the food and beverage sector.

    Founded 2015San Francisco, United States$4.0Mlast round Jun 2023
  28. 28DeltagenDeltaGen is a private SaaS company founded in 2024, with headquarters in the United States and locations in San Francisco and Prague.

    DeltaGen is a private SaaS company founded in 2024, with headquarters in the United States and locations in San Francisco and Prague.

    Founded 2024San Francisco, United States$4.0Mlast round Nov 2024
  29. 29AstradaAstrada is a software company that provides financial infrastructure, payments, and automation services.

    Astrada is a software company that provides financial infrastructure, payments, and automation services.

    Founded -San Francisco, United States$3.8Mlast round May 2026
  30. 30BuiltfirstBuiltfirst is a developer of multi-use partner marketplace platform.

    Builtfirst is a developer of multi-use partner marketplace platform.

    Founded 2020San Francisco, United States$3.8Mlast round Dec 2021
  31. 31BoomerangAIBoomerangAI is a B2B SaaS platform founded in 2021, specializing in relationship-led revenue and go-to-market (GTM) data automation.

    BoomerangAI is a B2B SaaS platform founded in 2021, specializing in relationship-led revenue and go-to-market (GTM) data automation.

    Founded 2023San Francisco, United States$3.7Mlast round Mar 2022
  32. 32MinoaMinoa is a San Francisco-based B2B SaaS company founded in 2022.

    Minoa is a San Francisco-based B2B SaaS company founded in 2022.

    Founded 2023San Francisco, United States$2.7Mlast round May 2023
  33. 33BzaarBZAAR is a B2B cross-border marketplace founded in 2020 by Nishant Verman and Prasanth Nair, both former Flipkart employees.

    BZAAR is a B2B cross-border marketplace founded in 2020 by Nishant Verman and Prasanth Nair, both former Flipkart employees.

    Founded 2020San Francisco, United States$2.7Mlast round Aug 2023
  34. 34SendbloomSendbloom is a sales automation platform founded in 2013 and based in San Francisco, California.

    Sendbloom is a sales automation platform founded in 2013 and based in San Francisco, California.

    Founded 2013San Francisco, United States$2.6Mlast round Jan 2015
  35. 35VoicepanelVoicepanel is an AI-powered user research platform founded in 2023 and based in San Francisco, California.

    Voicepanel is an AI-powered user research platform founded in 2023 and based in San Francisco, California.

    Founded 2023San Francisco, United States$2.4Mlast round May 2024
  36. 36Strategikon PharmaClinical MaestroTM by Strategikon Pharma is the only commercially available software platform for clinical trial business management.

    Clinical MaestroTM by Strategikon Pharma is the only commercially available software platform for clinical trial business management.

    Founded 2017San Francisco, United States$2.3Mlast round Jun 2025
  37. 37SlashExpertsSlashExperts is a B2B software company based in San Francisco, founded in 2024.

    SlashExperts is a B2B software company based in San Francisco, founded in 2024.

    Founded 2024San Francisco, United States$2.0Mlast round Apr 2025
  38. 38Channel99Channel99 is a B2B performance marketing platform founded in 2022.

    Channel99 is a B2B performance marketing platform founded in 2022.

    Founded 2022San Francisco, United States$1.6Mlast round Oct 2025
  39. 39RavacanRAVACAN is a software company that specializes in direct sourcing and supply operations.

    RAVACAN is a software company that specializes in direct sourcing and supply operations.

    Founded 2019San Francisco, United States$1.6Mlast round Oct 2020
  40. 40VentlyVently helps hosts engage, monetize, manage ticketing, and grow communities with end-to-end management tools.

    Vently helps hosts engage, monetize, manage ticketing, and grow communities with end-to-end management tools.

    Founded 2023San Francisco, United States$1.2Mlast round Oct 2024
  41. 41VaeroPersonalize writing styles of LLMs

    Personalize writing styles of LLMs

    Founded 2023San Francisco, United States$1.2Mlast round Apr 2023
  42. 42SoptleSoptle is a High growth financial technology company providing access to fair and low cost credit to SMBs

    Soptle is a High growth financial technology company providing access to fair and low cost credit to SMBs

    Founded 2021San Francisco, United States$1.0Mlast round May 2023
  43. 43DurateDurate is a healthcare technology company that specializes in automating physician scheduling for various healthcare settings, including hospitals, clinics, and

    Durate is a healthcare technology company that specializes in automating physician scheduling for various healthcare settings, including hospitals, clinics, and

    Founded 2024San Francisco, United States$500Klast round Dec 2024
  44. 44CraftOSAt CraftOS, we understand the challenges faced by small craft beverage suppliers and buyers alike.

    At CraftOS, we understand the challenges faced by small craft beverage suppliers and buyers alike.

    Founded 2023San Francisco, United States$500Klast round Sept 2023
  45. 45Shor (YC S25)Shor is a Y Combinator company founded in 2025, based in San Francisco.

    Shor is a Y Combinator company founded in 2025, based in San Francisco.

    Founded 2025San Francisco, United States$500Klast round Jul 2025
  46. 46CerulionCerulion is a robotics software company that develops an open-source, Rust-based middleware platform designed for robots and real-time systems.

    Cerulion is a robotics software company that develops an open-source, Rust-based middleware platform designed for robots and real-time systems.

    Founded -San Francisco, United States$500Klast round Jan 2026
  47. 47Vora AIVora supplies each hiring manager with an artificial intelligence-powered recruiting assistant.

    Vora supplies each hiring manager with an artificial intelligence-powered recruiting assistant.

    Founded -San Francisco, United States$500Klast round Mar 2025
  48. 48VovanaVovana is an AI recruitment platform that allows users to automate the sourcing and screening of candidates.

    Vovana is an AI recruitment platform that allows users to automate the sourcing and screening of candidates.

    Founded -San Francisco, United States$500Klast round Mar 2025
  49. 49SnowpilotSnowpilot connects data from your SaaS tools, that allows run important workflows without needing an engineer.

    Snowpilot connects data from your SaaS tools, that allows run important workflows without needing an engineer.

    Founded -San Francisco, United States$500Klast round Sept 2024
  50. 50SoffSoff is an AI-powered supply chain operating system founded in 2024 and headquartered in San Francisco, California.

    Soff is an AI-powered supply chain operating system founded in 2024 and headquartered in San Francisco, California.

    Founded -San Francisco, United States$500Klast round Sept 2024
Total fundinghow the list is ranked
15 November 2026updated nightly
Rounds we tracksource: Millionrounds

Companies whose funding rounds we classed in this sector, ranked by the total they have raised in rounds we hold. Nobody pays to be on a list.

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