Investors · new episode 20 Oct 2026
Invest Like the Best
Hosted by Patrick O'Shaughnessy
Long, careful conversations with investors and operators about how they think.
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Investors named as guests in the most episode titles on Invest Like the Best.
Every episode 602 · page 1 of 21
- 602Christina Cacioppo - Building an Enduring Software Company in the Age of AI - [Invest Like the Best, EP.496]20 Oct 2026 · 57 minChristina Cacioppo▶Show page
About this episode
My guest today is Christina Cacioppo, founder and CEO of Vanta, which helps more than 16,000 companies manage security and compliance. Five years after our first conversation, we discuss how Vanta became a category leader, what it takes to reinvent a successful software business in the age of AI, and why Christina is…
- 601David Vélez - Building Nubank and the Future of Global Banking - [Invest Like the Best, EP.495]13 Oct 2026 · 1h 12m▶Show page
About this episode
David Vélez is the founder and CEO of Nubank, which serves 140 million customers across Latin America. David believes the industry is still in its Blockbuster era, with most of the world's banking still running through branches and incumbent banks, and that AI will make digital banks dramatically more efficient than…
- 600Andrew Huberman - The Frontier of Neurotechnology - [Invest Like the Best, EP.494]6 Oct 2026 · 1h 12m▶Show page
About this episode
Andrew Huberman is a neuroscientist and professor at Stanford, the host of the Huberman Lab podcast, and the author of Protocols. Most of our conversation is about where neuroscience goes next. For decades the field has focused on reading from the brain, and Andrew believes the next era is about writing to it with…
- 599Noah Shinn - Building Instinct: The Personal Agent - [Invest Like the Best, EP.493]28 Sept 2026 · 1h 12m▶Show page
About this episode
My guest today is Noah Shinn. Noah is the founder of Instinct, a personal assistant that you text, call, or email the same way you would a person. It has its own phone and its own computer, and it can do almost anything on your behalf that you would do yourself online. Instinct is about a year old, still invite-only,…
- 598Gabe Stengel - Building Investing Superintelligence - [Invest Like the Best, EP.492]22 Sept 2026 · 1h 4m▶
About this episode
Gabe Stengel is the co-founder and CEO of Rogo, the AI platform for finance. He believes the best investors will spend the next several years reinventing their firms around AI, and Rogo is trying to build the infrastructure that allows them to do it. We discuss how Rogo evolved alongside the frontier models, why the…
- 597Michael Moritz - Lessons From 40 Years of Investing and Writing - [Invest Like the Best, EP.491]16 Sept 2026 · 1h 12mMichael MoritzElon MuskSequoia Capital▶Show page
About this episode
Michael Moritz led Sequoia Capital for nearly two decades and backed some of the defining companies of the internet era. In his new memoir, Ausländer, he turns his attention to his own family, Jewish refugees who fled Nazi Germany and rebuilt their lives in Wales. We discuss the imprint his parents left on him, the…
- 596Walter Russell Mead - How America Keeps Winning - [Invest Like the Best, EP.490]8 Sept 2026 · 1h 18m▶Show page
About this episode
My guest today is Walter Russell Mead. Walter is a columnist at the Wall Street Journal and the author of Special Providence and God and Gold, two of the best books written on American power. He has spent decades studying how the United States came to dominate the world, and our conversation is about whether it can…
- 595Sarah Guo - Funding the Frontier - [Invest Like the Best, EP.489]1 Sept 2026 · 60 minSarah Guo▶Show page
About this episode
My guest today is Sarah Guo, founder and managing partner of Conviction, the venture firm she built to back AI-native companies from their earliest days. Sarah has become one of the most sought-after early-stage investors in AI, often the first check into the companies defining the frontier. In this conversation, we…
- 594Neil Movva - Making AI 10x Cheaper - [Invest Like the Best, EP.488]25 Aug 2026 · 1h 18m▶Show page
About this episode
My guest today is Neil Movva, founder of Sail. Sail is building what Neil calls a token factory, an inference company designed for a specific kind of future, one where AI agents run in the background for hours or days at a time rather than answering a human in real time. In that world, latency matters less and cost…
- 593Ben Thompson on Big Tech, China, and the AI Boom Running Out of Money - [Invest Like the Best, EP.487]18 Aug 2026 · 1h 16mBen ThompsonGoogle▶Show page
About this episode
My guest today is Ben Thompson, the founder and author of Stratechery. Ben is one of my favorite business thinkers and I love talking to him about everything happening in markets and technology. We go through every important company, including OpenAI, Nvidia, Intel, Apple, Microsoft, Google, and Amazon. We also…
- 592Eric Vishria - A Decade of Lessons Investing in Software & Hardware - [Invest Like the Best, EP.486]11 Aug 2026 · 1h 6mEric Vishria▶Show page
About this episode
My guest today is Eric Vishria, a General Partner at Benchmark. Eric has spent his career in software and cloud, and few people know the history of these markets as well as he does. What makes him special is his ability to use that history to make sense of today. We discuss what the rise of AWS teaches us about AI,…
- 591Gavin Baker - AI Market Jitters - [Invest Like the Best, EP.485]4 Aug 2026 · 1h 5mGavin BakerAtreides Management▶
About this episode
My guest today is Gavin Baker, founding partner and CIO of Atreides Management. This is our seventh conversation, and just two months after Gavin's last appearance. It's about the gap between what the market is doing and what companies are seeing. It's been a tough month or so for public AI names, but there's no sign…
- 590Sam Altman - How to Make an Abundant Future - [Invest Like the Best, EP.484]28 Jul 2026 · 54 minSam Altman▶Show page
About this episode
My guest today is Sam Altman, CEO of OpenAI. It's a conversation spanning the history, present, and future of OpenAI, from the origin of ChatGPT through Codex, hardware, and their new Jalapeno chip. We discuss the early decision to buy compute at a scale nobody thought was rational, and the plan to build a gigawatt of…
- 589Matthew Smith, Natural Gas: The Next Bottleneck - [Invest Like the Best, EP.483]21 Jul 2026 · 57 min▶Show page
About this episode
My guest today is Matthew Smith. Matthew is the founder and CIO of Chronometer Partners, which invests in energy, industrials, materials, power and utilities, and related infrastructure. For the last 18 months he and his team have modeled nearly every natural gas well, pipeline, and processing asset in the United…
- 588John Kim - How to Raise a Few Billion Dollars - [Invest Like the Best, EP.482]14 Jul 2026 · 50 minJohn Kim▶Show page
About this episode
Today my guest is John Kim. John is one of the world's top and most prolific fundraisers. He was chief client officer at General Catalyst, where he helped raise many of the firm's flagship funds. He is now chairman and president of corporate development at Lila Sciences, a company building scientific…
- 587Jeremy Giffon - The Billion Dollar PDF - [Invest Like the Best, EP.481]7 Jul 2026 · 1h 15m▶Show page
About this episode
My guest today is Jeremy Giffon. Jeremy has been on the show before as one of our most popular guests, and this conversation is every bit as enjoyable as the first. Over the last 18 months, Jeremy has had hundreds of conversations with founders and with the capital behind their companies. I don't know many investors…
- 586Etched - Building AI Hardware to Make Inference Faster and Cheaper - [Invest Like the Best, EP.480]30 Jun 2026 · 1h 27m▶Show page
About this episode
My guests today are Gavin Uberti and Rob Wachen, the founders of Etched. A few years ago, when they set out to build a better AI chip than the largest companies in the world, almost everyone I called told me it could not be done. They have since done it, taping out a working chip on their first attempt and becoming…
- 585Vlad Barbalat - Investing $120 Billion in Permanent Capital - [Invest Like the Best, EP.479]23 Jun 2026 · 1h 10mLiberty Mutual Investments▶Show page
About this episode
My guest today is Vlad Barbalat, the Chief Investment Officer of Liberty Mutual Investments, the $120 billion investment platform that sits within one of the largest insurance companies in the world. Vlad grew up in Soviet Moldova, came to America in 1990, and built a career that eventually led him to one of the most…
- 584Kareem Amin - The Unusual Approach to Company Building - [Invest Like the Best, EP.478]16 Jun 2026 · 57 min▶Show page
About this episode
My guest today is Kareem Amin, co-founder and CEO of Clay. Clay has become one of the fastest-growing software companies of the last few years, valued at over four billion dollars. It helps companies find their best customers and reach them at scale. But this conversation is about a lot more than Clay. Kareem is one…
- 583Alex Sacerdote - How to Invest Through Technology Cycles - [Invest Like the Best, EP.477]9 Jun 2026 · 1h 11mAlex SacerdoteWhale Rock▶Show page
About this episode
My guest today is Alex Sacerdote, founder of Whale Rock Capital Management. Whale Rock is a technology focused investment firm that manages more than $17 billion across hedge fund, long only, and hybrid strategies. Over the past three years it has been one of the best performing hedge funds, compounding at roughly 44…
- 582Dara Khosrowshahi - Uber's Bet on AVs, AI, and Building a Super-App - [Invest Like the Best, EP.476]3 Jun 2026 · 1h 7mDara KhosrowshahiReed HastingsBarry Diller▶Show page
About this episode
My guest today is Dara Khosrowshahi, the CEO of Uber. Before Uber, Dara ran Expedia for thirteen years. We start with why he took this job in 2017, and a big part of that story is Daniel Ek, who told him that life is not about happiness, it is about impact. We talk about what the chaos felt like on day one, and how…
- 581Dan Loeb - Lessons from 30 Years of Investing - [Invest Like the Best, EP.475]28 May 2026 · 1h 3mWarburg Pincus▶Show page
About this episode
My guest today is Dan Loeb, the founder and CEO of Third Point. Dan started Third Point in 1995 with a few million dollars, and today the firm manages over 24 billion across equities, corporate and structured credit, venture, and insurance. He is best known for his activist work at companies like Sotheby's, Sony,…
- 580Darren Farber on Iran, China, and the Rise of Neoprimes - [Invest Like the Best, EP.474]26 May 2026 · 46 minDarren Farber▶Show page
About this episode
My guest today is Darren Farber, and this is his second appearance on the show. Darren is a Managing Partner of Albion River, a defense-focused investment firm and he previously served as a special advisor to the Deputy Under Secretary of Defense. We recorded this conversation in the middle of the Iranian contingency,…
- 579Gavin Baker - Watts and Wafers - [Invest Like the Best, EP.473]20 May 2026 · 1h 17mGavin BakerAtreides Management▶Show page
About this episode
My guest today is Gavin Baker, founding partner and CIO of Atreides Management, and this is our sixth conversation. The central theme is watts and wafers, the two physical constraints that in Gavin's view will dictate the next phase of AI. On power, he thinks the near-term shortage starts to ease in 2027 and 2028 as…
- 578Krishna Rao - Anthropic's CFO on Compute, Scaling to $30B ARR, and the Returns to Frontier Intelligence - [Invest Like the Best, EP.472]13 May 2026 · 1h 16mKrishna Rao▶Show page
About this episode
My guest today is Krishna Rao, the CFO of Anthropic. The center of our conversation is how he navigates the decision around procuring and allocating compute, which he describes as the canvas on which everything else gets built. We talk about what he calls the cone of uncertainty, the three chip platforms Anthropic…
- 577Brian Chesky - AI Founder Mode - [Invest Like the Best, EP.471]5 May 2026 · 1h 15mBrian Chesky▶Show page
About this episode
My guest today is Brian Chesky, the co-founder and CEO of Airbnb. Our conversation traces the path from his early training as an industrial designer at RISD through the pandemic moment that forced him into founder mode. He explains why he thinks AI founder mode will demand even more attention to the details and why…
- 576Paul Tudor Jones - Lessons From 50 Years in Markets - [Invest Like the Best, EP.470]28 Apr 2026 · 1h 7m▶Show page
About this episode
My guest today is Paul Tudor Jones. Paul is the founder of Tudor Investment Corporation and one of the greatest macro traders of all time, known for calling and profiting from the 1987 crash and compounding capital at extraordinary rates over more than four decades. Paul is also one of the most entertaining and…
- 575Dylan Patel - The Infinite Demand for Tokens, Claude Mythos, and Supply Constraints - [Invest Like the Best, EP.469]23 Apr 2026 · 45 min▶Show page
About this episode
This is my second conversation with Dylan Patel. Dylan is the founder and CEO of SemiAnalysis, where he tracks the semiconductor supply chain and AI infrastructure buildout. This conversation is about the supply and demand of tokens. On demand, Dylan describes something completely explosive. He explains why the…
- 574Alex Karnal - The Trillion-Dollar Health Revolution - [Invest Like the Best, EP.468]21 Apr 2026 · 1h 32mRevolutionDeerfield▶Show page
About this episode
My guest today is Alex Karnal. Alex is the co-founder and managing partner of Braidwell, a life sciences investment firm he built after spending 15 years at Deerfield Management. The frame we use throughout the episode is the health stack. Alex talks about how most of the diseases that will claim most of our lives…
- 573Scott Nolan - SpaceX, Founders Fund, and Rebuilding American Uranium Enrichment - [Invest Like the Best, EP.467]14 Apr 2026 · 1h 16mScott NolanFounders FundPeter Thiel▶Show page
About this episode
Scott Nolan spent 12 years at Founders Fund looking for the most important problems that no one else was funding. Then he found a problem so critical, and so ignored, that he couldn't find a company to back. So he started one. General Matter is rebuilding US uranium enrichment. The United States was the world leader…
Who the show talks about
Firms named in its episodes, and people named in descriptions: talked about, rather than on the show.
