Top list · San Mateo

Startups in San Mateo

254 startups in San Mateo have raised money in rounds we track. These are the 50 that have raised the most, $16B between them.

$16Braised by these 50
254on our record in all
Snowflakeraised the most
  1. 1SnowflakeSnowflake is a cloud data platform that provides a data warehouse as a service designed for the cloud.

    Snowflake is a cloud data platform that provides a data warehouse as a service designed for the cloud.

    Founded 2012San Mateo, United States$4.6Blast round Sept 2026
  2. 2Fireworks AIFireworks AI is a generative AI infrastructure platform that specializes in delivering fast inference and full-parameter training for open-source AI models.

    Fireworks AI is a generative AI infrastructure platform that specializes in delivering fast inference and full-parameter training for open-source AI models.

    Founded 2022San Mateo, United States$1.7Blast round Oct 2026
  3. 3UpstartUpstart connects millions of consumers to 100+ banks and credit unions who leverage Upstart's artificial intelligence models and cloud applications to deliver s

    Upstart connects millions of consumers to 100+ banks and credit unions who leverage Upstart's artificial intelligence models and cloud applications to deliver s

    Founded -San Mateo, United States$1.6Blast round Apr 2026
  4. 4VerkadaVerkada Inc.

    Verkada Inc.

    Founded 2016San Mateo, United States$1.6Blast round Jul 2026
  5. 5SiFiveSiFive is a platform offering open-source semiconductor technology and software automation.

    SiFive is a platform offering open-source semiconductor technology and software automation.

    Founded 2015San Mateo, United States$700Mlast round Apr 2026
  6. 6AlpacaAlpaca is a brokerage infrastructure company based in San Mateo, California, that specializes in providing an API-first platform for commission-free trading.

    Alpaca is a brokerage infrastructure company based in San Mateo, California, that specializes in providing an API-first platform for commission-free trading.

    Founded 2017San Mateo, United States$513Mlast round Jul 2026
  7. 7SkydioSkydio is a leading U.S.

    Skydio is a leading U.S.

    Founded 2014San Mateo, United States$350Mlast round Apr 2026
  8. 8CloudianCloudian is a file and object storage company that provides hybrid cloud data management software.

    Cloudian is a file and object storage company that provides hybrid cloud data management software.

    Founded 2011San Mateo, United States$324Mlast round Jun 2024
  9. 9RealiReali was a real estate and fintech company that operated a digital platform to simplify the homeownership journey.

    Reali was a real estate and fintech company that operated a digital platform to simplify the homeownership journey.

    Founded 2016San Mateo, United States$240Mlast round Aug 2021
  10. 10GeneralistGeneralist, also known as Generalist AI, is a robotics company based in San Mateo, California, with a mission to develop general-purpose robots that can operate

    Generalist, also known as Generalist AI, is a robotics company based in San Mateo, California, with a mission to develop general-purpose robots that can operate

    Founded 2024San Mateo, United States$200Mlast round Aug 2026
  11. 11Bluejay TherapeuticsBluejay Therapeutics is a private biopharmaceutical company focused on the development of cures for infectious diseases.

    Bluejay Therapeutics is a private biopharmaceutical company focused on the development of cures for infectious diseases.

    Founded 2019San Mateo, United States$182Mlast round May 2024
  12. 12SnapLogicSnapLogic is a software company that provides a platform for enterprise cloud and big data integration.

    SnapLogic is a software company that provides a platform for enterprise cloud and big data integration.

    Founded 2006San Mateo, United States$171Mlast round Oct 2019
  13. 13ObserveObserve offers an observability cloud solution to accelerate the transformation of troubleshooting applications and resolving incidents.

    Observe offers an observability cloud solution to accelerate the transformation of troubleshooting applications and resolving incidents.

    Founded 2017San Mateo, United States$156Mlast round Jul 2025
  14. 14Luma HealthLuma Health is a healthcare technology company founded in 2015 and based in San Mateo, California.

    Luma Health is a healthcare technology company founded in 2015 and based in San Mateo, California.

    Founded 2015San Mateo, United States$152Mlast round Nov 2021
  15. 15BigHat BiosciencesBigHat Biosciences is a biotechnology company founded in 2019 and based in San Mateo, California.

    BigHat Biosciences is a biotechnology company founded in 2019 and based in San Mateo, California.

    Founded 2019San Mateo, United States$150Mlast round Sept 2026
  16. 16Cala HealthCala Health is a bioelectronic medicine company based in San Mateo, California, founded in 2013.

    Cala Health is a bioelectronic medicine company based in San Mateo, California, founded in 2013.

    Founded 2014San Mateo, United States$150Mlast round Apr 2026
  17. 17NotableNotable is an AI-powered health start-up that automates and digitizes every physician-patient interaction.

    Notable is an AI-powered health start-up that automates and digitizes every physician-patient interaction.

    Founded 2017San Mateo, United States$145Mlast round Jul 2026
  18. 18vArmourVArmour offers data defined perimeter security solutions for mobile, virtual, and cloud platforms.

    VArmour offers data defined perimeter security solutions for mobile, virtual, and cloud platforms.

    Founded 2011San Mateo, United States$144Mlast round Feb 2021
  19. 19Motif InvestingMotif Investing was an online brokerage platform founded in June 2010 by Hardeep Walia and Tariq Hilaly, based in San Mateo, California.

    Motif Investing was an online brokerage platform founded in June 2010 by Hardeep Walia and Tariq Hilaly, based in San Mateo, California.

    Founded 2010San Mateo, United States$127Mlast round Jan 2015
  20. 20TileTile, Inc.

    Tile, Inc.

    Founded 2012San Mateo, United States$126Mlast round Apr 2024
  21. 21SendBirdSendbird is a global communications platform and a leading provider of Communications Platform as a Service (CPaaS) solutions.

    Sendbird is a global communications platform and a leading provider of Communications Platform as a Service (CPaaS) solutions.

    Founded 2013San Mateo, United States$118Mlast round Jan 2022
  22. 22AusperBioAusperBio is a clinical-stage biopharmaceutical company dedicated to advancing treatments for hepatitis B virus (HBV) and developing oligonucleotide therapeutics.

    AusperBio is a clinical-stage biopharmaceutical company dedicated to advancing treatments for hepatitis B virus (HBV) and developing oligonucleotide therapeutics.

    Founded 2019San Mateo, United States$113Mlast round Sept 2025
  23. 23ZinierZinier is a privately held company based in San Mateo, California, specializing in AI-native field service management (FSM) software.

    Zinier is a privately held company based in San Mateo, California, specializing in AI-native field service management (FSM) software.

    Founded 2018San Mateo, United States$112Mlast round Jan 2020
  24. 24CARGO TherapeuticsCARGO Therapeutics develops an adoptive cell therapy to benefit patients from potentially curative treatment options.

    CARGO Therapeutics develops an adoptive cell therapy to benefit patients from potentially curative treatment options.

    Founded 2019San Mateo, United States$110Mlast round May 2024
  25. 25NetomiNetomi is an American artificial intelligence company that specializes in agentic AI solutions for customer experience and service.

    Netomi is an American artificial intelligence company that specializes in agentic AI solutions for customer experience and service.

    Founded 2016San Mateo, United States$110Mlast round May 2026
  26. 26CalystaCalysta is a biotechnology company based in California, specializing in cellular agriculture.

    Calysta is a biotechnology company based in California, specializing in cellular agriculture.

    Founded 2011San Mateo, United States$109Mlast round Mar 2021
  27. 27EpiBiologicsEpiBiologics is a biotechnology company based in San Mateo, California, founded in 2022.

    EpiBiologics is a biotechnology company based in San Mateo, California, founded in 2022.

    Founded 2022San Mateo, United States$107Mlast round Jan 2026
  28. 28TalendTalend specializes in cloud data integration and data integrity.

    Talend specializes in cloud data integration and data integrity.

    Founded 2004San Mateo, United States$102Mlast round Dec 2013
  29. 29Beauty for all industriesBeauty for all industries is a powerhouse in beauty innovation.

    Beauty for all industries is a powerhouse in beauty innovation.

    Founded 2020San Mateo, United States$96Mlast round Feb 2022
  30. 30ExploriumExplorium is a B2B data technology company founded in 2017, headquartered in Tel Aviv, Israel, with additional offices in San Mateo, California, and Lehi, Utah.

    Explorium is a B2B data technology company founded in 2017, headquartered in Tel Aviv, Israel, with additional offices in San Mateo, California, and Lehi, Utah.

    Founded 2017San Mateo, United States$94Mlast round May 2021
  31. 31Kivu BioscienceAs a company focused on rapidly advancing next generation transformative assets, we leverage our expertise to efficiently progress programs to clinical proof of concept.

    As a company focused on rapidly advancing next generation transformative assets, we leverage our expertise to efficiently progress programs to clinical proof of concept.

    Founded 2024San Mateo, United States$92Mlast round Oct 2024
  32. 32EdmodoEdmodo is a global education network that connects all learners with the people and resources they need to reach their full potential.

    Edmodo is a global education network that connects all learners with the people and resources they need to reach their full potential.

    Founded 2008San Mateo, United States$88Mlast round Aug 2014
  33. 33ConversicaConversica creates intelligent virtual assistants to serve as virtual team members.

    Conversica creates intelligent virtual assistants to serve as virtual team members.

    Founded 2007San Mateo, United States$84Mlast round Oct 2018
  34. 34Neo4jNeo4j is a global leader in graph intelligence, recognized for its Neo4j Graph Database, a native graph database management system.

    Neo4j is a global leader in graph intelligence, recognized for its Neo4j Graph Database, a native graph database management system.

    Founded 2007San Mateo, United States$80Mlast round Nov 2018
  35. 35Salma HealthSalma Health is a comprehensive brain health clinic combining advanced diagnostics, personalized treatment and continuous care under one roof.

    Salma Health is a comprehensive brain health clinic combining advanced diagnostics, personalized treatment and continuous care under one roof.

    Founded 2016San Mateo, United States$80Mlast round Feb 2026
  36. 36Wonder WorkshopWonder Workshop provides a platform that makes programming fun and accessible for children while they play.

    Wonder Workshop provides a platform that makes programming fun and accessible for children while they play.

    Founded 2012San Mateo, United States$78Mlast round Oct 2017
  37. 37Yellow.aiYellow.ai is a conversational AI platform, enabling enterprises to unlock business potential at scale.

    Yellow.ai is a conversational AI platform, enabling enterprises to unlock business potential at scale.

    Founded 2016San Mateo, United States$78Mlast round Aug 2021
  38. 38Arkose LabsArkose Labs is a global leader in proactive fraud deterrence and account security, based in San Mateo, California.

    Arkose Labs is a global leader in proactive fraud deterrence and account security, based in San Mateo, California.

    Founded 2016San Mateo, United States$76Mlast round May 2021
  39. 39Vivace TherapeuticsVivace Therapeutics is a venture-backed start-up dedicated to discovering and developing cancer therapeutics by targeting a novel pathway.

    Vivace Therapeutics is a venture-backed start-up dedicated to discovering and developing cancer therapeutics by targeting a novel pathway.

    Founded 2014San Mateo, United States$75Mlast round Mar 2025
  40. 40icixICIX enables real-time coordination across supply chain and trading partner networks to manage sourcing, sustainability, safety and go-to-market initiatives.

    ICIX enables real-time coordination across supply chain and trading partner networks to manage sourcing, sustainability, safety and go-to-market initiatives.

    Founded 2004San Mateo, United States$75Mlast round Jan 2017
  41. 41Swing EducationSwing Education is a technology-driven substitute staffing platform founded in 2015.

    Swing Education is a technology-driven substitute staffing platform founded in 2015.

    Founded 2015San Mateo, United States$73Mlast round Jul 2025
  42. 42WisdomAIWisdomAI is a private AI and data analytics company based in San Mateo, California, founded in 2023.

    WisdomAI is a private AI and data analytics company based in San Mateo, California, founded in 2023.

    Founded 2023San Mateo, United States$73Mlast round Nov 2025
  43. 43ModeMODE is driven to help organizations leverage their data to improve operations, safety, & efficiencies through the use of IoT & AI

    MODE is driven to help organizations leverage their data to improve operations, safety, & efficiencies through the use of IoT & AI

    Founded 2014San Mateo, United States$70Mlast round Apr 2026
  44. 44KaonAI Personalized Content Media

    AI Personalized Content Media

    Founded -San Mateo, United States$70Mlast round Jul 2026
  45. 45Sonitus MedicalSonitus Medical provides clinically effective non-invasive and removable hearing solutions based on the bone conduction method.

    Sonitus Medical provides clinically effective non-invasive and removable hearing solutions based on the bone conduction method.

    Founded 2006San Mateo, United States$68Mlast round Apr 2014
  46. 46BriteCoreBriteCore is a cloud-native core insurance platform tailored for Property & Casualty (P&C) insurers.

    BriteCore is a cloud-native core insurance platform tailored for Property & Casualty (P&C) insurers.

    Founded 2009San Mateo, United States$68Mlast round Sept 2021
  47. 47RocksetRockset is a real-time indexing database that enables companies to build data applications for the cloud.

    Rockset is a real-time indexing database that enables companies to build data applications for the cloud.

    Founded 2016San Mateo, United States$66Mlast round Aug 2023
  48. 48Helicore BiopharmaHelicore Biopharma is a private biopharmaceutical company based in San Mateo, California, focused on developing innovative weight-loss therapeutics and treatmen

    Helicore Biopharma is a private biopharmaceutical company based in San Mateo, California, focused on developing innovative weight-loss therapeutics and treatmen

    Founded 2025San Mateo, United States$65Mlast round Jan 2025
  49. 49B-StockB-Stock is the largest B2B recommerce platform, providing a technology-driven marketplace for businesses to purchase returned, excess, trade-in, and overstock i

    B-Stock is the largest B2B recommerce platform, providing a technology-driven marketplace for businesses to purchase returned, excess, trade-in, and overstock i

    Founded 2008San Mateo, United States$65Mlast round Jun 2018
  50. 50Lattice EnginesLattice Engines specializes in the fields of marketing, sales, data-driven business applications, and trigger events.

    Lattice Engines specializes in the fields of marketing, sales, data-driven business applications, and trigger events.

    Founded 2006San Mateo, United States$65Mlast round Jun 2015
Total fundinghow the list is ranked
15 November 2026updated nightly
Rounds we tracksource: Millionrounds

Every startup we hold in San Mateo, ranked by the total it has raised in rounds we hold. Nobody pays to be on a list.

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