Top list · Durham
Startups in Durham
138 startups in Durham have raised money in rounds we track. These are the 50 that have raised the most, $6.9B between them.
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Cypress Creek RenewablesCypress Creek Renewables is a national provider of local solar.Cypress Creek Renewables is a national provider of local solar.
Founded 2014Durham, United States$3.5Blast round Jun 2026 - 2
BioventusBioventus delivers clinically proven, cost-effective products that help people heal quickly and safely.Bioventus delivers clinically proven, cost-effective products that help people heal quickly and safely.
Founded -Durham, United States$412Mlast round Jul 2025 - 3
AvalaraAvalara is a cloud-based platform that provides tax compliance software and automated solutions.Avalara is a cloud-based platform that provides tax compliance software and automated solutions.
Founded 2004Durham, United States$329Mlast round Sept 2016 - 4
Strata Clean EnergyStrata Clean Energy is a solar storage developer.Strata Clean Energy is a solar storage developer.
Founded 2008Durham, United States$300Mlast round Nov 2023 - 5
HumacyteHumacyte, Inc.Humacyte, Inc.
Founded 2004Durham, United States$297Mlast round Mar 2018 - 6
Heelstone Renewable EnergyHeelstone Energy is a leading independent power producer and solar developer with expertise in developing, financing, constructing.Heelstone Energy is a leading independent power producer and solar developer with expertise in developing, financing, constructing.
Founded 2012Durham, United States$200Mlast round Jan 2026 - 7
HigharcHigharc is a cloud-based Homebuilding Intelligence platform founded in 2018 by CEO Marc Minor in Durham, NC.Higharc is a cloud-based Homebuilding Intelligence platform founded in 2018 by CEO Marc Minor in Durham, NC.
Founded 2018Durham, United States$169Mlast round Jun 2026 - 8
Atsena TherapeuticsAtsena Therapeutics is a clinical-stage gene therapy company based in Durham, North Carolina, focused on developing treatments for inherited retinal diseases (IAtsena Therapeutics is a clinical-stage gene therapy company based in Durham, North Carolina, focused on developing treatments for inherited retinal diseases (I
Founded 2019Durham, United States$150Mlast round Apr 2025 - 9
Restor3drestor3d is a medical device company based in Durham, North Carolina, specializing in additive manufacturing for orthopedics.restor3d is a medical device company based in Durham, North Carolina, specializing in additive manufacturing for orthopedics.
Founded 2017Durham, United States$104Mlast round Aug 2025 - 10
SMART WIRESSmart Wires is a grid solutions company that offers monitoring and power flow control in meshed networks.Smart Wires is a grid solutions company that offers monitoring and power flow control in meshed networks.
Founded 2010Durham, United States$104Mlast round Jan 2025 - 11
ServiceTradeServiceTrade offers mobile and web apps for maintenance businesses to deliver more service calls and connect with their customers.ServiceTrade offers mobile and web apps for maintenance businesses to deliver more service calls and connect with their customers.
Founded 2012Durham, United States$90Mlast round Dec 2021 - 12
SpreedlySpreedly is a global open payments orchestration platform based in Durham, North Carolina.Spreedly is a global open payments orchestration platform based in Durham, North Carolina.
Founded 2008Durham, United States$80Mlast round Nov 2019 - 13
KevelKevel, Inc.Kevel, Inc.
Founded 2010Durham, United States$75Mlast round Oct 2026 - 14
Areteia TherapeuticsAreteia Therapeutics, Inc.Areteia Therapeutics, Inc.
Founded 2022Durham, United States$75Mlast round Feb 2024 - 15
PhononicPhononic develops thermoelectric chips designed to offer an alternative to compressor technology and traditional methods of refrigeration.Phononic develops thermoelectric chips designed to offer an alternative to compressor technology and traditional methods of refrigeration.
Founded 2008Durham, United States$70Mlast round Nov 2016 - 16
JupiterOneJupiterOne is a cloud-native cybersecurity platform that specializes in Cyber Asset Attack Surface Management (CAASM).JupiterOne is a cloud-native cybersecurity platform that specializes in Cyber Asset Attack Surface Management (CAASM).
Founded 2018Durham, United States$70Mlast round Jun 2022 - 17
BaebiesBaebies is a medical device company based in Durham, North Carolina, focused on improving newborn screening and pediatric testing through innovative digital micBaebies is a medical device company based in Durham, North Carolina, focused on improving newborn screening and pediatric testing through innovative digital mic
Founded 2014Durham, United States$70Mlast round May 2022 - 18
PowerSecure InternationalPowerSecure International provides utility and energy technologies to electric utilities and their industrial and commercial customers.PowerSecure International provides utility and energy technologies to electric utilities and their industrial and commercial customers.
Founded 1991Durham, United States$65Mlast round Sept 2015 - 19Idera PharmaceuticalsIdera Pharmaceuticals merged with Aceragen, Inc., a rare disease biopharmaceutical company, in September 2022.
Idera Pharmaceuticals merged with Aceragen, Inc., a rare disease biopharmaceutical company, in September 2022.
Founded 1989Durham, United States$54Mlast round Feb 2014 - 20
RibometrixRibometrix is a platform therapeutics company that discovers small molecule drugs to treat human diseases.Ribometrix is a platform therapeutics company that discovers small molecule drugs to treat human diseases.
Founded 2014Durham, United States$45Mlast round Sept 2019 - 21
DigitalsmithsDigitalsmiths connects consumers to relevant video content through personalized search, recommendations, and discovery.Digitalsmiths connects consumers to relevant video content through personalized search, recommendations, and discovery.
Founded 2006Durham, United States$38Mlast round Feb 2014 - 22
SciodermScioderm, a clinical stage pharmaceutical company, develops topical products for the treatment of chronic skin diseases.Scioderm, a clinical stage pharmaceutical company, develops topical products for the treatment of chronic skin diseases.
Founded 2012Durham, United States$37Mlast round Dec 2014 - 23
BiomasonBiomason, Inc.Biomason, Inc.
Founded 2012Durham, United States$37Mlast round Jan 2025 - 24
ValidicValidic is a technology platform that offers digital health and remote care programs for healthcare organizations.Validic is a technology platform that offers digital health and remote care programs for healthcare organizations.
Founded 2010Durham, United States$30Mlast round Jan 2023 - 25
410 Medical410 Medical is a medical device company dedicated to developing innovative products that enable frontline medical providers to improve care.410 Medical is a medical device company dedicated to developing innovative products that enable frontline medical providers to improve care.
Founded 2013Durham, United States$29Mlast round Jul 2026 - 26Vascular PharmaceuticalsVascular Pharmaceuticals engages in the development of therapeutics targeting the treatment of diabetes associated complications.
Vascular Pharmaceuticals engages in the development of therapeutics targeting the treatment of diabetes associated complications.
Founded 2005Durham, United States$26Mlast round Mar 2015 - 27
Bantam PharmaceuticalBantam Pharmaceutical, also known as Bantam Pharma, is a clinical-stage biopharmaceutical company founded in 2015 and based in Durham, North Carolina.Bantam Pharmaceutical, also known as Bantam Pharma, is a clinical-stage biopharmaceutical company founded in 2015 and based in Durham, North Carolina.
Founded 2015Durham, United States$25Mlast round Sept 2021 - 28
PairwisePairwise is an agricultural biotechnology company based in Durham, North Carolina, founded in 2017 by Dr.Pairwise is an agricultural biotechnology company based in Durham, North Carolina, founded in 2017 by Dr.
Founded 2017Durham, United States$25Mlast round Mar 2018 - 29
RamonaRamona develops high-throughput microscopy tools to unlock previously impossible experiments within the modern biology lab.Ramona develops high-throughput microscopy tools to unlock previously impossible experiments within the modern biology lab.
Founded 2018Durham, United States$25Mlast round Sept 2026 - 30
LabConnectLabConnect is a leading provider of central laboratory services and clinical trial support solutions, established in 2002 and headquartered in Johnson City, Tennessee.LabConnect is a leading provider of central laboratory services and clinical trial support solutions, established in 2002 and headquartered in Johnson City, Tennessee.
Founded 2002Durham, United States$25Mlast round Jun 2017 - 31
T3D TherapeuticsT3D Therapeutics is a company developing remedial therapeutics for Alzheimer’s disease and other CNS disorders.T3D Therapeutics is a company developing remedial therapeutics for Alzheimer’s disease and other CNS disorders.
Founded 2013Durham, United States$24Mlast round Sept 2022 - 32
Kincell BioKincell Bio is a cell therapy Contract Development and Manufacturing Organization (CDMO) founded in 2023 as a spin-out from Inceptor Bio.Kincell Bio is a cell therapy Contract Development and Manufacturing Organization (CDMO) founded in 2023 as a spin-out from Inceptor Bio.
Founded 2023Durham, United States$22Mlast round Sept 2026 - 33
Keebler HealthKeebler Health is a healthcare technology company based in Durham, North Carolina, founded in 2023.Keebler Health is a healthcare technology company based in Durham, North Carolina, founded in 2023.
Founded 2023Durham, United States$22Mlast round Apr 2026 - 34
BIOMILQBIOMILQ is a North Carolina-based biotechnology company focused on developing cell-cultured human milk to enhance infant nutrition.BIOMILQ is a North Carolina-based biotechnology company focused on developing cell-cultured human milk to enhance infant nutrition.
Founded 2019Durham, United States$21Mlast round Oct 2021 - 35
Mendel BiotechnologyMendel Biotechnology is a plant biotechnology company that develops genetic and chemical solutions for a range of agricultural markets.Mendel Biotechnology is a plant biotechnology company that develops genetic and chemical solutions for a range of agricultural markets.
Founded 1997Durham, United States$20Mlast round Nov 2011 - 36
FoodLogiQFoodLogiQ provides a food traceability, food safety, food sustainability, and supply chain transparency software.FoodLogiQ provides a food traceability, food safety, food sustainability, and supply chain transparency software.
Founded 2006Durham, United States$20Mlast round Mar 2018 - 37
XilisXilis is an oncology and precision health company that provides technologies to diagnoses cancer.Xilis is an oncology and precision health company that provides technologies to diagnoses cancer.
Founded 2019Durham, United States$19Mlast round Apr 2025 - 38
Spyryx BiosciencesSpyryx Biosciences develops a next-generation therapeutics for obstructive lung diseases.Spyryx Biosciences develops a next-generation therapeutics for obstructive lung diseases.
Founded 2013Durham, United States$18Mlast round May 2015 - 39
Tavros TherapeuticsTavros Therapeutics is an emerging biotechnology company that discovers and develops therapies for cancer.Tavros Therapeutics is an emerging biotechnology company that discovers and develops therapies for cancer.
Founded 2019Durham, United States$18Mlast round Oct 2022 - 40
ArpioArpio, Inc.Arpio, Inc.
Founded 2018Durham, United States$16Mlast round Jun 2026 - 41
Incyclix BioIncyclix Bio, LLC is a biotechnology company based in Research Triangle Park, North Carolina, founded in 2020 by experts in cyclin-dependent kinase (CDK) research.Incyclix Bio, LLC is a biotechnology company based in Research Triangle Park, North Carolina, founded in 2020 by experts in cyclin-dependent kinase (CDK) research.
Founded 2020Durham, United States$16Mlast round Apr 2026 - 42
NuvotronicsNuvotronics designs, develops, and fabricates custom networks of circuits and passive components for complex microwave systems.Nuvotronics designs, develops, and fabricates custom networks of circuits and passive components for complex microwave systems.
Founded 2008Durham, United States$15Mlast round Jul 2015 - 43
PolareanPolarean is manufacturer and service provider for noble gas polarizer devices and ancillary instruments.Polarean is manufacturer and service provider for noble gas polarizer devices and ancillary instruments.
Founded 2011Durham, United States$15Mlast round May 2024 - 44
RevianRevian is the manufacturer and supplier of medical-grade LED technology.Revian is the manufacturer and supplier of medical-grade LED technology.
Founded 2016Durham, United States$13Mlast round Nov 2025 - 45
BotBuiltBotBuilt is a construction technology startup based in Durham, North Carolina, founded in 2020.BotBuilt is a construction technology startup based in Durham, North Carolina, founded in 2020.
Founded 2020Durham, United States$12Mlast round Dec 2023 - 46
Automated InsightsAutomated Insights is the creator of Wordsmith, the world’s first public natural language generation platform.Automated Insights is the creator of Wordsmith, the world’s first public natural language generation platform.
Founded 2007Durham, United States$12Mlast round Jun 2014 - 47Duke Center for Autism and Brain DevelopmentThe Duke Center for Autism and Brain Development provides assistance to each person with autism and related developmental disabilities.
The Duke Center for Autism and Brain Development provides assistance to each person with autism and related developmental disabilities.
Founded -Durham, United States$12Mlast round Sept 2022 - 48
Keen Decision SystemsKeen Decision Systems is an AI-powered SaaS company founded in 2010, specializing in marketing mix modeling (MMM).Keen Decision Systems is an AI-powered SaaS company founded in 2010, specializing in marketing mix modeling (MMM).
Founded 2010Durham, United States$11Mlast round Jul 2022 - 49
The Looma ProjectThe people & stories behind your products.The people & stories behind your products.
Founded 2015Durham, United States$10Mlast round Sept 2024 - 50
Precision FermentationPrecision Fermentation offers real-time fermentation monitoring solution for the craft beer industry.Precision Fermentation offers real-time fermentation monitoring solution for the craft beer industry.
Founded 2017Durham, United States$10Mlast round Apr 2026
Durham, United StatesEvery startup we hold in Durham, ranked by the total it has raised in rounds we hold. Nobody pays to be on a list.
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