Portfolio map · Government fund · United States

Small Business Innovation Research portfolio map

51 startups Small Business Innovation Research has backed in rounds we track, since 2014, grouped by their main sector. Together they have raised $381M. The biggest sector is Biotech, with 13 companies.

51startups backed
8sectors
$381Mraised between them
Biotechbiggest sector

Small Business Innovation Research's investor profile

Biotech

13

Healthtech

8

AI

8

Edtech

6

Aerospace & Space

6

Big Data & Analytics

4

Pharma

3

Cleantech

3

Segment by segment

Biotech

13 startups · $21M raised

  1. Cell MicrosystemsCell Microsystems is a biotechnology company based in Durham, North Carolina, founded in 2010.United States$6.5M
  2. SpirovantSpirovant Sciences is developing novel gene therapies for cystic fibrosis and other pulmonary diseases.-$4.5M
  3. Hemex HealthHemex Health is a provider of a diagnostic device designed for populations at risk for malaria and sickle cell disease.United States$3.0M
  4. ATAvexegen TherapeuticsAvexegen Therapeutics is a biotechnology company developing therapies for gastrointestinal disorders.-$2.9M
  5. ProlocorProlocor is a biotechnology and healthcare startup based in Philadelphia, Pennsylvania, founded in 2020.United States$1.7M
  6. Kepley BioSystemsKepley BioSystems offers ocean restorative technology to help stem the continued depletion of wild fish.United States$1.0M
  7. Photonic PharmaPhotonic Pharma is an early phase of drug development-$499K
  8. Neuroene TherapeuticsDeveloping mitochondrial small molecule drugs for difficult to treat neurological diseases.United States$400K

Healthtech

8 startups · $114M raised

  1. SPR TherapeuticsSPR Therapeutics is a medical device company.United States$101M
  2. AIQ SolutionsAIQ Solutions develops a medical device technology platform that revolutionizes the treatment response of patients with complex diseases.United States$3.6M
  3. GeniPhysGeniPhys is a medical technology company that plans to develop and commercialize its patented technology.United States$3.0M
  4. ObsidioObsidio is a medical device company pioneering a biomaterial platform technology to enable minimally-invasive occlusion of blood vessels.-$3.0M
  5. Ayuda MedicalAyuda Medical is a medical device company that develops wearable devices and sensors to detect an overdose and call for help.United States$2.8M
  6. Symple SurgicalSymple Surgical is a medical device company focusing on developing novel therapeutic technologies through controlled microwave ablation.United States$400K
  7. Nucleic Sensing SystemsNucleic Sensing Systems is an environmental biotechnology company based in Saint Paul, Minnesota, founded in 2020.United States$175K
  8. SecmationSecmation offers technology, engineering solutions, and tools to integrate information security into industrial and defense products.United States$59K

AI

8 startups · $171M raised

  1. IAMBICAI-driven, precision-fit footwear.United States$167M
  2. Abstractive HealthAbstractive Health is a New York-based healthcare AI company founded in 2022.United States$1.4M
  3. SofthreadSofthread is a blockchain technology company that develops enterprise solutions using a blockchain and AI-enabled platform.United States$1.0M
  4. RedShredRedShred is an artificial intelligence startup.-$894K
  5. ChoositoChoosito!United States$325K
  6. Ada IQAI-driven platform assists product managers, designers, and related professionals in having better insights into customers' needsUnited States$275K
  7. GIANT BioSystemsGIANT BioSystems is a developer of an ultra-fast, next-generation platform for AST and high-throughput drug screening.United States$250K
  8. OqulloOqullo provides property managers with actionable insight into customer traffic.United States$250K

Edtech

6 startups · $4.7M raised

  1. OOcupathOcupath is seeks to modernize job shadowing and job training through augmented and virtual reality.-$1.0M
  2. MathBRIXMathBRIX is a highly visual, concept-based approach to teaching math, backed by decades of research.United States$1.0M
  3. LiterablyLiterably is a K-8 literacy assessment system that sends results to teachers after students read out loud into a device.United States$1.0M
  4. 2Sigma School2Sigma School provides courses in computer science and data science.United States$1.0M
  5. Just PhysiologyJustPhysiology is an online learning resource composed of interactive experiments powered by HumModTM.-$441K
  6. Parametric StudioParametric Studio is an Ed-Tech company specialized in developing engineering-centric and project based STEM software products.-$225K

Aerospace & Space

6 startups · $12M raised

  1. ExoTerraExoTerra's mission is to enable more exploration of space by making it affordable to a larger market.United States$8.0M
  2. bluShift AerospaceScalable, reusable propulsion for defense and space.United States$1.3M
  3. QubitSolveQubitSolve is developing a software that helps helps engineers in conducting fast and accurate CFD simulations on quantum computers.United States$1.2M
  4. VertiPrime Government ServicesVertiPrime Government Services is a service disable veteran owned full spectrum solution provider.-$1.0M
  5. Vestigo AerospaceVestigo Aerospace provides deorbit capability for cubeSats, small satellites, and launch vehicle stages.United States$375K
  6. Elemental CoatingsElemental Coatings, based in Houston, Texas, is a chemical manufacturing company founded in 2018.United States$150K

Big Data & Analytics

4 startups · $49M raised

  1. Accrete AIDual Use AI for defense, Intelligence and cybersecurity.United States$40M
  2. FIRMMFIRMM is a real-time MRI quality metrics to reduce costs and improve quality.-$6.6M
  3. MaalkaCities, corporations, and large building portfolio owners use Maalka manage sustainability for thousands of buildings at a time.-$1.0M
  4. AtheraxonAtheraxon is an Atlanta-based company specializing in industrial location and spatial intelligence.United States$1.0M

Pharma

3 startups · $3.8M raised

  1. Stem PharmStem Pharm's synthetic biomaterials support the optimization of cell expansion.United States$2.6M
  2. CytocyberneticsCytocybernetics is a Biotechnology which specializes in cellular electrophysiologyUnited States$1.0M
  3. SBSonoran BiosciencesSonoran Biosciences is an early stage pharmaceutical company that has developed SB Gel, the first viscous sustained release carrier.United States$260K

Cleantech

3 startups · $4.9M raised

  1. MagDrive TechnologiesMagDrive Technologies is a magnetically actuated valve drive capable of producing torque.United States$3.5M
  2. RiKarbonRiKarbon is a green-tech company that develops renewable products using captured carbon emissions by minimizing waste through innovation.United States$1.1M
  3. Lunexus SpaceEnergizing the Circular Economy in SpaceUnited States$275K

How this map is made. Every startup here has raised money in a round we track that names Small Business Innovation Research as an investor, the first in 2014. Each sits under its main sector, read from its rounds, and each sector shows its best-funded first; sectors with fewer than three companies are left off. Rebuilt nightly; updated 15 November 2026.

More portfolio maps

All portfolios
Government fund · United StatesNational Science Foundation988 startups · 12 sectors · $10BGovernment fund · United StatesUS Department of Energy259 startups · 12 sectors · $38BGovernment fund · United StatesNational Institutes of Health232 startups · 7 sectors · $3.3BGovernment fund · United StatesInternational Finance Corporation134 startups · 12 sectors · $23BGovernment fund · United StatesConnecticut Innovations93 startups · 12 sectors · $2.5BGovernment fund · United StatesInnovation Works88 startups · 12 sectors · $1.2B

Raising from investors like Small Business Innovation Research?

Find the investors who back startups like yours, with their cheques, rounds and partners, in the app with filters, lists and exports.

Find investorsMarket maps