Sector portfolio · VC firm · United States

Longwood Fund's Biotech portfolio

Longwood Fund has backed 27 Biotech startups in rounds we track, $2.4B between them, shown by the stage each has reached. The best-funded is Tome Biosciences.

27startups backed
4stages
$2.4Braised between them
Series Bbiggest stage

Longwood Fund's profile

Segment by segment

Series B

11 startups · $1.1B raised

  1. NNeomorphUnited States$209M
  2. Mediar TherapeuticsMediar Therapeutics is a clinical-stage biotechnology company based in Boston, Massachusetts, founded in 2018-2019.United States$161M
  3. AAVantgarde BioAAVantgarde Bio is developing gene therapies for inherited retinal disorders.Italy$141M
  4. Sidewinder TherapeuticsSidewinder Therapeutics is a biotechnology company that offers life-saving therapies for cancer and rare diseases.United States$137M
  5. Lassen TherapeuticsLassen Therapeutics is a clinical-stage biopharmaceutical company based in San Diego, California.United States$85M
  6. TScan TherapeuticsTScan Therapeutics is a biopharmaceutical company focused on the development of immunotherapy treatments for cancer.United States$78M
  7. XyloCor TherapeuticsXyloCor Therapeutics is a bio-pharmaceutical company intended to develop gene therapy for people with advanced coronary artery disease.United States$68M
  8. Avenzo TherapeuticsDeveloping the next generation of oncology therapies for patients.United States$60M

Series A

10 startups · $724M raised

  1. Tome BiosciencesTome Biosciences is a biotechnology company based in Watertown, MA, focused on advancing programmable genomic integration (PGI) toUnited States$213M
  2. Newleos TherapeuticsNewleos Therapeutics is a clinical-stage neuroscience and biotechnology company based in Boston, Massachusetts.United States$94M
  3. Photys TherapeuticsPhotys Therapeutics is a biotechnology and pharmaceutical research company founded in 2021 and based in Waltham, Massachusetts.United States$75M
  4. 2T27-8 TherapeuticsUnited States$65M
  5. PTProgentos TherapeuticsProgentos Therapeutics develops an approach to treat multiple sclerosis that stimulates the body's natural repair mechanisms.United States$65M
  6. WTWereworld TherapeuticsUnited States$56M
  7. ImmuneIDImmuneID is a precision immunology company.-$50M
  8. Solu TherapeuticsSolu Therapeutics is a Boston-based clinical-stage biotechnology company focused on developing precision medicines to target and eUnited States$41M

Series C and later

4 startups · $427M raised

  1. ArcherDXArcherDX is a biotechnology firm specializing in cancer research.United States$150M
  2. Calithera BiosciencesCalithera Biosciences is a pharmaceutical company developing novel small molecule therapeutics for the treatment of cancer.United States$115M
  3. PulmocidePulmocide is a private biopharmaceutical company based in London, United Kingdom, founded in 2007.United Kingdom$110M
  4. Channel MedsystemsChannel Medsystems is a medical device company offering cryotherapy devices for endometrial cryoablation.United States$52M

Stage not reported

2 startups · $175M raised

  1. EvommuneEvommune is a biotechnology company that develops therapeutics that halt progressive disease and address their symptoms.United States$125M
  2. Werewolf TherapeuticsWerewolf Therapeutics operates as an oncology biotherapeutics company.United States$50M

How this map is made. Every startup here works in Biotech and has raised money in a round we track that names Longwood Fund as an investor. Each sits under the stage of its latest round. Rebuilt nightly; updated 15 November 2026.

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