Investors · new episode 25 Oct 2026
The a16z Show
Hosted by Andreessen Horowitz
Andreessen Horowitz's partners and guests on technology, company building and where they invest.
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- 1026The New Startup Playbook | Box CEO Aaron Levie25 Oct 2026 · 34 minAaron Levie▶Show page
About this episode
Can a 10-person startup outperform a company with hundreds of employees? Box CEO Aaron Levie argues AI agents are giving small teams a level of leverage that simply wasn't economically possible before, creating a window for startups to outrun incumbents. In this episode of Speedrun Office Hours, Aaron explains why…
- 1025What It Takes to Win as a Founder | Ben Horowitz24 Oct 2026 · 42 minBen HorowitzAndrew Chen▶Show page
About this episode
What does it take to build a company when AI is changing the rules this quickly? Ben Horowitz argues that technology may make companies easier to start, but the hardest parts of entrepreneurship, making decisions under uncertainty, building momentum, and managing your own doubts, aren't going away. Speedrun's Andrew…
- 1024Amazon CEO Andy Jassy on the $220 Billion AI Buildout23 Oct 2026 · 1h 1mBen Horowitz▶Show page
About this episode
Amazon expects to spend roughly $220 billion in CapEx in 2026, yet CEO Andy Jassy says the company is still leaving meaningful AI demand on the table.** He believes the buildout could ultimately help make AWS a $1 trillion annual run-rate business. Andy joins a16z co-founder Ben Horowitz and Erik Torenberg to discuss…
- 1023The Frontier Ideas a16z Wants to Fund | Marc Andreessen, Ben Horowitz & Chris Dixon22 Oct 2026 · 1h 1mBen HorowitzChris DixonMarc Andreessen▶Show page
About this episode
a16z is expanding a16z crypto into a16z Frontier, a broader mandate to back founders building at the edges of what's possible. Chris Dixon joins Marc Andreessen, Ben Horowitz, and Erik Torenberg to explain why founders should increasingly ask not “is this too ambitious?” but “is this ambitious enough?”, and how AI…
- 1022The Missing Infrastructure for AI Agents: Documents | Reducto’s Adit Abraham21 Oct 2026 · 38 min▶Show page
About this episode
AI agents can reason over enormous amounts of information, but much of the world’s actual work is still trapped in PDFs, spreadsheets, scans, and other formats that models struggle to reliably understand. Reducto co-founder and CEO Adit Abraham argues that solving this document layer is essential if agents are going…
- 1021What Happens When Everyone Has a Health Expert in Their Pocket? | OpenAI’s Karan Singhal20 Oct 2026 · 56 min▶Show page
About this episode
More than 300 million people use ChatGPT for health and wellness questions each week. OpenAI’s Karan Singhal thinks that’s only the beginning: the longer-term goal is AI that can help people navigate their health proactively, while making trustworthy medical intelligence dramatically more accessible. Karan joins a16z…
- 1020What Happens When Al Agents Can Spend Your Money?19 Oct 2026 · 1h 3mAlex RampellJean-Denis Greze▶Show page
About this episode
Why hasn't AI transformed everyday work as quickly as coding? Town CEO Jean-Denis Greze argues the bottleneck isn't intelligence, but making AI useful to people who don't have the time or technical skills to build their own automations. Jean-Denis joins a16z General Partner Alex Rampell to share why he pivoted Town…
- 1019Why Real-World AI Is Harder Than the Benchmark | EliseAI’s Mario Martone18 Oct 2026 · 24 min▶Show page
About this episode
What changes when an AI mistake doesn’t just hurt a benchmark score, but affects someone’s housing or healthcare? EliseAI Head of Applied Research Mario Martone argues that deploying AI in essential industries requires a very different standard of reliability. Mario joins MTS to explain how EliseAI handles roughly 5…
- 1018Why AI Could Finally Fix Healthcare Access | Zocdoc CEO Oliver Kharraz17 Oct 2026 · 35 min▶Show page
About this episode
Why is booking a doctor's appointment still so difficult, and can AI finally change that? Zocdoc CEO Oliver Kharraz argues that the real problem isn't finding doctors, but connecting patients to accurate availability and making appointments bookable wherever they start their search. Oliver joins a16z General Partner…
- 1017AI Can Write the Code. Can It Run the System? | Grepr CEO Jad Naous16 Oct 2026 · 1h 0m▶Show page
About this episode
a16z General Partner Martin Casado sits down with Grepr CEO Jad Naous to ask what comes after AI learns to write code: can it also debug and operate the systems that code creates? Jad shares how AI has transformed engineering inside his 10-person team, cutting some projects from six months to just 10 days. But…
- 1016When AI Agents Start Spending Your Money | Alex Rampell & Terry Angelos15 Oct 2026 · 51 minAlex Rampell▶Show page
About this episode
a16z General Partner Alex Rampell sits down with VGS Executive Board Member, Terry Angelos, to unpack what happens to payments when AI agents go from recommending what to buy to actually making the purchase. Terry explains the infrastructure required to safely give agents access to payment credentials, why wallets…
- 1015Can Open Models Keep Up With the AI Frontier? | Nathan Lambert14 Oct 2026 · 60 min▶Show page
About this episode
a16z Partner Lisha Li sits down with AI researcher and Trillium founder Nathan Lambert to ask how durable the gap really is between frontier AI labs and open models. Nathan argues that OpenAI and Anthropic have structural advantages in compute, capital, and the ability to pioneer new training paradigms, but…
- 1014Can AI Break Cryptography? What the Experts Actually Think13 Oct 2026 · 42 minDan Boneh▶Show page
About this episode
Could AI break the cryptography protecting everything from crypto wallets and banking to private messages? Recent advances in AI-driven mathematical research have sparked new warnings about the security of today's encryption systems, but how much of the concern is supported by evidence? a16z crypto's Liz Harkavy is…
- 1013The Race to Recursive Self-Improving AI12 Oct 2026 · 33 min▶Show page
About this episode
a16z General Partner Martin Casado sits down with MakerMaker.AI co-founders Dhaval Adjodah and Owen He to unpack recursive self-improvement, or RSI, and separate the increasingly popular term from what it would actually mean for an AI system to improve itself. Dhaval and Owen distinguish true RSI from simply using AI…
- 1012Nick Bostrom: How Should We Navigate Superintelligence?11 Oct 2026 · 54 min▶Show page
About this episode
Nick Bostrom joins Theo Jaffee and Sofia Puccini on MTS to revisit the ideas about superintelligence and existential risk that he helped bring into the mainstream, now that increasingly capable AI systems actually exist. Nick discusses why reinforcement learning may be pushing models toward more goal-seeking…
- 1011What Makes a Great Entrepreneur? | Ben Horowitz on Vintage x Vintage10 Oct 2026 · 52 minBen Horowitz▶Show page
About this episode
a16z co-founder and General Partner Ben Horowitz joins James Norman on the inaugural episode of Vintage x Vintage for a conversation spanning entrepreneurship, investing, hip-hop, and what changes when AI makes building dramatically easier. Ben reflects on going from Netscape to becoming a first-time CEO, why every…
- 1010Chips, Memory, and Power | Pat Gelsinger9 Oct 2026 · 54 minPlayground Global▶Show page
About this episode
a16z's Raghu Raghuram and Guido Appenzeller sit down with Playground Global General Partner and former Intel CEO Pat Gelsinger to discuss the next wave of semiconductor innovation and the physical constraints shaping the AI buildout. Drawing on his experience designing Intel's 386 and 486 processors, Pat explains how…
- 1009Building the Cloud for an Agentic World | AWS CEO Matt Garman8 Oct 2026 · 56 min▶Show page
About this episode
a16z’s Raghu Raghuram sits down with AWS CEO Matt Garman to discuss how AI is reshaping the cloud, from the needs of AI-native startups to infrastructure increasingly designed for agents. Matt explains how AWS is adapting as agents write code and manage infrastructure, why it’s reserving scarce GPU capacity for…
- 1008How Valon Rebuilt a $13 Trillion Industry From Scratch7 Oct 2026 · 41 min▶Show page
About this episode
a16z General Partner Angela Strange sits down with Valon’s Andrew Wang and Linda Du to unpack what it takes to rebuild the infrastructure underneath a $13 trillion mortgage market that still relies heavily on systems designed before the internet. Linda and Andrew explain why Valon chose the hardest path: becoming a…
- 1007Building Defense for the Agentic Era: Kevin Mandia6 Oct 2026 · 49 minKevin Mandia▶Show page
About this episode
a16z General Partner David George sits down with Armadin founder and CEO Kevin Mandia to discuss what happens to cybersecurity when attackers can operate at machine speed. After 30 years in security and building Mandiant, Kevin says AI convinced him to get back on the field. He explains how AI changes the economics…
- 1006The Top 100 Consumer AI Apps: Who’s Actually Paying?5 Oct 2026 · 51 minJosh Elman▶Show page
About this episode
a16z Editorial Partner Elena Burger sits down with investing partners Olivia Moore and Josh Elman to unpack the seventh edition of a16z’s Top 100 Consumer AI Apps, including a new dimension this time: what consumers are actually paying for. The data reveals a striking power-user economy. Only a small share of…
- 1005David George & Jack Altman on AI, Autonomy, and the Next $25 Trillion4 Oct 2026 · 55 minJack Altman▶Show page
About this episode
a16z General Partner David George joins Jack Altman on Uncapped to make the case that many of the biggest debates in AI are framed the wrong way. Frontier models or open source? Labs or applications? David’s answer is often “and.” With AI adoption still concentrated among a relatively small group of heavy users, he…
- 1004Beyond the God Model | Alex Atallah & Amjad Masad3 Oct 2026 · 48 minAmjad Masad▶Show page
About this episode
A16z’s Erik Torenberg sits down with OpenRouter’s Alex Atallah and Replit founder and CEO Amjad Masad to discuss why the future of AI may look less like one all-purpose model and more like an ecosystem of specialized models working together. Alex explains why OpenRouter is betting on “neurodiversity”: different…
- 1003Why AI Agents Can Beat the Incumbents2 Oct 2026 · 60 min▶Show page
About this episode
a16z’s Seema Amble and Elena Burger sit down with Lio co-founder and CEO Vladimir Keil to ask where AI-native startups have an advantage when incumbent software companies already own the customer, the data, and the system of record. Their answer comes down to the work that happens outside those systems. In…
- 1002Rebuilding the Internet for Privacy | Barrett Lyon on DoxxNet1 Oct 2026 · 45 min▶Show page
About this episode
a16z’s Joel de la Garza sits down with DoxxNet founder Barrett Lyon to discuss what it would take to rebuild the internet around privacy, direct communication, and less dependence on centralized intermediaries. Barrett explains why he thinks traditional VPNs only solve part of the problem and how DoxxNet is building…
- 1001The $1 Trillion AI Buildout | State of Markets30 Sept 2026 · 54 min▶Show page
About this episode
a16z’s David George, Sarah Wang, Alex Immerman, and Santiago Rodriguez unpack 25 key charts from the latest State of Markets presentation, from the scale of the AI infrastructure buildout to what adoption looks like inside companies today. They examine why rising markets have so far been supported by earnings rather…
- 1000The Personal Agent Race Is Here | Anish Acharya & David Pawlan29 Sept 2026 · 51 min▶Show page
About this episode
a16z General Partner Anish Acharya sits down with Assistant Benchmark creator David Pawlan to unpack the sudden explosion of personal AI agents and what it will take for one to become part of everyday life. David has been testing dozens of assistants across real-world tasks, from managing email and booking travel to…
- 999AI Can Write Code. Why Isn’t Software Better?28 Sept 2026 · 43 minBen HorowitzDiogo Almeida▶Show page
About this episode
a16z’s Ben Horowitz and Martin Casado sit down with TypeSafe AI founder Diogo Almeida to ask a simple question: AI has become remarkably capable, so where is all the automation? Diogo argues that coding agents may help us write software faster, but the software they produce still largely works the way software always…
- 998Building a Team at AI Speed | Harvey’s Maggie Landers27 Sept 2026 · 48 min▶Show page
About this episode
a16z’s Katie Kirsch sits down with Harvey VP of Talent Maggie Landers to discuss what happens inside a company growing at AI speed, and how you preserve culture while adding more than 1,000 employees in a year. Maggie explains why Harvey prioritizes progress over perfection, how its values of simplicity,…
- 997Aaron Levie, Steven Sinofsky & Martin Casado: How Do You Secure a World of AI Agents?26 Sept 2026 · 56 minAaron Levie▶Show page
About this episode
Erik Torenberg sits down with Box CEO Aaron Levie, and a16z’s Martin Casado, and Steven Sinofsky to debate how the AI industry should think about safety, security, and regulation as increasingly capable agents move into the real world. They argue that much of today’s conversation is happening before we have clearly…
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Firms named in its episodes, and people named in descriptions: talked about, rather than on the show.
