What does 406 Ventures invest in?
406 Ventures invests most often at Series A and Series B (58% of the rounds on record), in sectors such as Healthcare, Data and AI.

United States · Investor
Last cheque observed Oct 2026; 136 cheques on record.
Deploying nowNew fund $245M, Feb 2024VC firm
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6 cheques in the last 12 months
Mostly Series A and Series B: 58% of its rounds
Sole investor in 16 rounds, median $4.5M
7 exits from the portfolio
.406 Ventures is the partner for early-stage companies with home run potential.From their own website
Every round we can evidence, newest first136 appearances
4 rounds
10 rounds
11 rounds
10 rounds
8 rounds
An announcement gives the size of the round, not the size of this investor's cheque: the only rounds that imply a cheque are those where they were the sole named investor.
Named by the firm itself, on a filing, its Form ADV or its company registration10 named
We also hold 21 people at this firm from the lists this database was built from: a weaker source than the filings, since a list does not say when a title ended. Login to see them.
From the firm's own filings with the SEC, which it must file accurately by law
From their own portfolio page (on their website)
AbacusinsightsAbsurdAristamdBighealthChaossearchClosedloopCorpFamilywellhealthGenesiscomputingHeartbeathealthHyprIndicodataKeeboMindgardNemahealthOnapsisOncoverycarePortraitanalyticsPromethiumRadsecurityRandoriRedoxengineRelaiTrilioValeriehealthVitalizeWayspringWelbehealthWellistArboretumAscellusBiadvisorsBluebirdkidsBobsledClarenhealthCorticacareEquipGamestrongHelmhealthHeydianahealthInstrideLynx-fhNaceOnbelayhealthsolutionsQuellsecureRapidfireRooncyberSevcoTelmThetasoftware
Weaker than a round we watched, stronger than a list somebody sold us. A firm is far less willing to put a company on its own site that it never funded.
Companies it backed that were later bought or listed7 in all
An exit counts when it came after the firm's first round in the company. From historical deal records.
The investors most often in the same rounds as 406 Ventures. A count of rooms they were both in, not a relationship either has claimed.
The latest companies 406 Ventures put money into.
406 Ventures invests most often at Series A and Series B (58% of the rounds on record), in sectors such as Healthcare, Data and AI.
136 investments on record, 6 of them in the last 12 months, and it led 5. The most recent was in Oct 2026.
Its most recent investments on record: Vitalize (Series A, Oct 2026), Mindgard (Series A, Aug 2026) and InStride Health (Series C, Jun 2026).
The median round it joins is $15M.
Sometimes: it led 5 of its 136 investments on record (4%).
Most of the companies it backs are in the United States (90%) and the United Kingdom (8%).
Yes: it is actively investing, with 6 investments in the last 12 months.
Most often Polaris Partners (12 rounds together), Atlas Venture (11 rounds together) and Y Combinator (8 rounds together).
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Built from the rounds we watched, its filings and its own website, refreshed every night. How we count · Report a correction · Is this your firm? Claim it