United States · Investor

406 Ventures

Last cheque observed Oct 2026; 136 cheques on record.

Deploying nowNew fund $245M, Feb 2024VC firm

Pre-seedSeedSeries AHealthcareDataAI

Deploying now
46%of best year6cheques in 12 months, 136 on record
Since the last cheque23days00hrs00min00sec
Median round$15MRounds led5 of 136Sole investor16 roundsExits7 from the portfolioMostly inUnited States, 90%
Pitch 406 Ventures

406 Ventures highlights

  1. 01

    6 cheques in the last 12 months

  2. 02

    Mostly Series A and Series B: 58% of its rounds

  3. 03

    Sole investor in 16 rounds, median $4.5M

  4. 04

    7 exits from the portfolio

What they do

.406 Ventures is the partner for early-stage companies with home run potential.From their own website
Type
VC firm (from a list, unverified)
Cheque size
Not stated
Stages
Pre-seedSeedSeries ASeries BGrowthPre-IPO
Sectors
HealthcareDataAI
Based in
Boston, United States
Cold pitches
Not stated

The record

Every round we can evidence, newest first136 appearances

  1. 2026

    4 rounds

  2. Oct
    VitalizeSeries A · US · MedCity News$31MWith 6 others
  3. Aug
    MindgardSeries A · GB$30MWith 3 others
  4. Jun
    InStride HealthSeries C · US · Echo Health Ventures$30MWith 5 others
  5. Feb
  6. 2025

    10 rounds

  7. Dec
    Nomad HealthVenture · US$34MWith 7 others
  8. Nov
    FamilyWell HealthSeries A · US$8.0MSole investor
  9. Oct
    Indico DataVenture · USUndisclosedWith 5 others
  10. Sept
    Diana HealthSeries C · US$55MWith 4 others
  11. Sept
    RapidFire AIPre-seed · US$4.0MSole investor
  12. Jul
    Equip HealthVenture · US$47MWith 4 others
  13. May
    RedoxUS$12MWith 3 others
  14. Mar
    Bluebird Kids HealthSeries A · US$32MSole investor
  15. Feb
    Rad SecuritySeries A · US$14MWith 2 others
  16. Feb
    LynxSeries A · GB$27MWith 3 others
  17. 2024

    11 rounds

  18. Dec
    MindgardVenture · GB$8.2MWith 3 others
  19. Dec
    TausightVenture · USUndisclosedWith 4 others
  20. Nov
    Nema HealthSeries A · US$15MWith 2 others
  21. Nov
    CorticaVenture · IL$80MWith 5 others
  22. Jul
    Heartbeat HealthSeries C · US$25MWith 4 others
  23. Jun
    HYPRVenture · US$30MWith 3 others
  24. Jun
    Humata HealthSeries A · US$25MWith 2 others
  25. May
    OncoveryCareSeed · US$4.5MWith 1 other
  26. May
    WayspringSeries D · US$45MSole investor
  27. Mar
    TausiPre-seed · US$450KWith 4 others
  28. Mar
    InStride HealthSeries B · US$30MWith 1 other
  29. 2023

    10 rounds

  30. Nov
    AristaMDSeries C · US$17MWith 2 others
  31. Aug
    Better Life PartnersSeries B · US$27MWith 2 others
  32. Aug
    Simon DataSeries D · US$54MWith 4 others
  33. Aug
    Simon AISeries D · US$54MWith 4 others
  34. Jul
    Portrait AnalyticsSeed · US$7.0MWith 1 other
  35. Jun
    LaudioSeries B · US$13MSole investor
  36. Jun
    Sevco SecurityVenture · US$17MWith 3 others
  37. Jun
    TelmaiSeed · US$5.5MWith 3 others
  38. Apr
    Bobsled, Inc.Series A · US$17MWith 4 others
  39. Feb
    WellistDebt · US$165KSole investor
  40. 2022

    8 rounds

  41. Dec
    TrilioSeries B · US$17MWith 1 other
  42. Dec
    retrain.aiVenture · US$14MWith 2 others
  43. Oct
    OortSeries A · US$12MWith 4 others
  44. Aug
    ClosedLoopVenture · US$25KWith 5 others
  45. Aug
    ThreatXSeries B · US$30MWith 1 other

An announcement gives the size of the round, not the size of this investor's cheque: the only rounds that imply a cheque are those where they were the sole named investor.

The team

Named by the firm itself, on a filing, its Form ADV or its company registration10 named

GDGregory DraconPartner of the General PartneriFiling they signed
JGJohn Graham BrooksPartner of the General PartneriFiling they signed
LBLawrence BegleyMember of .406 Ventures II GP, LLC (the ""GP LLC""), the general partner of .406 Ventures II GP, L.P. (the ""General Partner""), the general partneriFiling they signed
LSLiam Sean DonohueMember of the general partner of the Issuer's ManageriFiling they signed
MCMaria CirinoMember of the general partner of the Issuer's ManageriFiling they signed
PEPaul E. WalkerManager of the General Partner.iFiling they signed
PDPayal DivakaranPartner of the General PartneriFiling they signed
RCRick C. YangManager of the General Partner.iFiling they signed
SDScott D. SandellManager of the General Partner.iFiling they signed
SMSo-June Min DonohueDirectoriForm ADV

We also hold 21 people at this firm from the lists this database was built from: a weaker source than the filings, since a list does not say when a title ended. Login to see them.

What the register says

From the firm's own filings with the SEC, which it must file accurately by law

$1.6Bgross assets of its fundsOct 2026
Exemptreporting adviserventure or small private funds
Legal name
.406 Ventures Management, L.P.
SEC number
CRD 162914

What they claim to have backed

From their own portfolio page (on their website)

29 of 50 we have independently watched raise

AbacusinsightsAbsurdAristamdBighealthChaossearchClosedloopCorpFamilywellhealthGenesiscomputingHeartbeathealthHyprIndicodataKeeboMindgardNemahealthOnapsisOncoverycarePortraitanalyticsPromethiumRadsecurityRandoriRedoxengineRelaiTrilioValeriehealthVitalizeWayspringWelbehealthWellistArboretumAscellusBiadvisorsBluebirdkidsBobsledClarenhealthCorticacareEquipGamestrongHelmhealthHeydianahealthInstrideLynx-fhNaceOnbelayhealthsolutionsQuellsecureRapidfireRooncyberSevcoTelmThetasoftware

Weaker than a round we watched, stronger than a list somebody sold us. A firm is far less willing to put a company on its own site that it never funded.

Exits from the portfolio

Companies it backed that were later bought or listed7 in all

DigitalsmithsBought by TiVo$135MJan 2014
WellAWARE SystemsBought by HealthsenseUndisclosedJul 2013
EnergyHubBought by Alarm.comUndisclosedMay 2013
MasheryBought by IntelUndisclosedApr 2013
MementoBought by FISUndisclosedApr 2012
ThingMagicBought by TrimbleUndisclosedOct 2010
PGP TrustCenterBought by PGP CorporationUndisclosedFeb 2010

An exit counts when it came after the firm's first round in the company. From historical deal records.

Who they invest alongside

The investors most often in the same rounds as 406 Ventures. A count of rooms they were both in, not a relationship either has claimed.

Recently backed

The latest companies 406 Ventures put money into.

Quick answers about 406 Ventures

What does 406 Ventures invest in?

406 Ventures invests most often at Series A and Series B (58% of the rounds on record), in sectors such as Healthcare, Data and AI.

How active is 406 Ventures?

136 investments on record, 6 of them in the last 12 months, and it led 5. The most recent was in Oct 2026.

What has 406 Ventures invested in recently?

Its most recent investments on record: Vitalize (Series A, Oct 2026), Mindgard (Series A, Aug 2026) and InStride Health (Series C, Jun 2026).

How big are 406 Ventures's cheques?

The median round it joins is $15M.

Does 406 Ventures lead rounds?

Sometimes: it led 5 of its 136 investments on record (4%).

Where does 406 Ventures invest?

Most of the companies it backs are in the United States (90%) and the United Kingdom (8%).

Is 406 Ventures investing now?

Yes: it is actively investing, with 6 investments in the last 12 months.

Who does 406 Ventures invest alongside?

Most often Polaris Partners (12 rounds together), Atlas Venture (11 rounds together) and Y Combinator (8 rounds together).

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Built from the rounds we watched, its filings and its own website, refreshed every night. How we count · Report a correction · Is this your firm? Claim it