Top list · South San Francisco
Startups in South San Francisco
126 startups in South San Francisco have raised money in rounds we track. These are the 50 that have raised the most, $14B between them.
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VerilyLearn how Verily's AI-native data platform unifies complex health data with robust governance, accelerating research and care to deliver real-world impact for pLearn how Verily's AI-native data platform unifies complex health data with robust governance, accelerating research and care to deliver real-world impact for p
Founded -South San Francisco, United States$1.3Blast round Mar 2026 - 2
Xaira TherapeuticsXaira Therapeutics is an integrated biotechnology company founded in 2023 and publicly launched in April 2024.Xaira Therapeutics is an integrated biotechnology company founded in 2023 and publicly launched in April 2024.
Founded 2023South San Francisco, United States$1.0Blast round Apr 2024 - 3
Structure TherapeuticsStructure Therapeutics specializes in the discovery and development of drugs against a type of targets called GPCR.Structure Therapeutics specializes in the discovery and development of drugs against a type of targets called GPCR.
Founded 2016South San Francisco, United States$748Mlast round Dec 2025 - 4
NewLimitNewLimit is a biotechnology company based in South San Francisco, California, focused on extending human healthspan through innovative medicines that restore yoNewLimit is a biotechnology company based in South San Francisco, California, focused on extending human healthspan through innovative medicines that restore yo
Founded 2022South San Francisco, United States$610Mlast round Jun 2026 - 5
IDEAYA BiosciencesIDEAYA Biosciences is an oncology-focused biotechnology company that develops therapeutics for patients with genetically-defined cancers.
IDEAYA Biosciences is an oncology-focused biotechnology company that develops therapeutics for patients with genetically-defined cancers.
Founded 2015South San Francisco, United States$608Mlast round Jun 2026 - 6
FreenomeFreenome is a biotechnology company with a comprehensive multiomics platform for cancer detection using a routine blood draw.Freenome is a biotechnology company with a comprehensive multiomics platform for cancer detection using a routine blood draw.
Founded 2014South San Francisco, United States$553Mlast round Jul 2026 - 7
ArsenalBioArsenalBio is a programmable cell therapy company that offers advanced CAR T-cell therapies for solid tumors.ArsenalBio is a programmable cell therapy company that offers advanced CAR T-cell therapies for solid tumors.
Founded 2019South San Francisco, United States$410Mlast round Sept 2024 - 8
Global Blood TherapeuticsGBT is a clinical-stage biopharmaceutical company developing a therapy for sickle cell disease.GBT is a clinical-stage biopharmaceutical company developing a therapy for sickle cell disease.
Founded 2011South San Francisco, United States$389Mlast round Dec 2021 - 9
Encoded TherapeuticsEncoded Therapeutics is a Harnessing the regulatory genome to create next-generation molecular therapies.Encoded Therapeutics is a Harnessing the regulatory genome to create next-generation molecular therapies.
Founded 2014South San Francisco, United States$379Mlast round Sept 2026 - 10
Pliant TherapeuticsPliant Therapeutics focuses on discovering, developing, and commercializing breakthrough treatments for fibrotic diseases.Pliant Therapeutics focuses on discovering, developing, and commercializing breakthrough treatments for fibrotic diseases.
Founded 2015South San Francisco, United States$350Mlast round Jan 2023 - 11
NGM BiopharmaceuticalsNGM Biopharmaceuticals Inc.NGM Biopharmaceuticals Inc.
Founded 2008South San Francisco, United States$333Mlast round Mar 2015 - 12
TricidaTricida operates in the healthcare industry focusing on pharmaceutical business.Tricida operates in the healthcare industry focusing on pharmaceutical business.
Founded 2013South San Francisco, United States$327Mlast round Oct 2022 - 13
Star TherapeuticsStar Therapeutics is a clinical-stage biotechnology company based in South San Francisco, California, founded in 2018.Star Therapeutics is a clinical-stage biotechnology company based in South San Francisco, California, founded in 2018.
Founded 2018South San Francisco, United States$325Mlast round Oct 2026 - 14
Allogene TherapeuticsAllogene Therapeutics is a biotechnology company catalyzing cancer treatment through the development of CAR T therapy.Allogene Therapeutics is a biotechnology company catalyzing cancer treatment through the development of CAR T therapy.
Founded 2017South San Francisco, United States$310Mlast round Apr 2026 - 15
Maze TherapeuticsMaze Therapeutics is an operator of a biotechnology firm used to focus on translating genetic insights into new medicines.Maze Therapeutics is an operator of a biotechnology firm used to focus on translating genetic insights into new medicines.
Founded 2018South San Francisco, United States$300Mlast round Apr 2026 - 16
Terremoto BiosciencesTerremoto Biosciences is a clinical-stage biotechnology company founded in 2021, focused on covalent drug discovery and development.Terremoto Biosciences is a clinical-stage biotechnology company founded in 2021, focused on covalent drug discovery and development.
Founded 2021South San Francisco, United States$283Mlast round Apr 2026 - 17
GlydwaysGlydways, Inc.Glydways, Inc.
Founded 2016South San Francisco, United States$271Mlast round Apr 2026 - 18
Vera TherapeuticsVera Therapeutics is a biotechnology company developing innovative biologic therapeutics with transformative clinical potential.Vera Therapeutics is a biotechnology company developing innovative biologic therapeutics with transformative clinical potential.
Founded 2016South San Francisco, United States$261Mlast round Dec 2025 - 19
SurrozenSurrozen is a biopharmaceutical that focuses on unlocking the body’s regenerative power to treat injury and disease.Surrozen is a biopharmaceutical that focuses on unlocking the body’s regenerative power to treat injury and disease.
Founded 2015South San Francisco, United States$258Mlast round Mar 2025 - 20
CellaresCellares is a biotechnology company based in South San Francisco, California, and is recognized as the world’s first Integrated Development and Manufacturing OrCellares is a biotechnology company based in South San Francisco, California, and is recognized as the world’s first Integrated Development and Manufacturing Or
Founded 2019South San Francisco, United States$257Mlast round Jan 2026 - 21
Rapt TherapeuticsRapt is focused on the discovery and development of novel small-molecule agents to activate the immune system to eradicate cancer.Rapt is focused on the discovery and development of novel small-molecule agents to activate the immune system to eradicate cancer.
Founded 2015South San Francisco, United States$250Mlast round Oct 2025 - 22
ORIC PharmaceuticalsORIC Pharmaceuticals is a biopharmaceutical company that develops treatments that target the causes of therapeutic resistance.ORIC Pharmaceuticals is a biopharmaceutical company that develops treatments that target the causes of therapeutic resistance.
Founded 2014South San Francisco, United States$248Mlast round May 2025 - 23
Nkarta TherapeuticsNkarta Therapeutics is a developer of cell engineering platform created to build the next generation of cell therapies.
Nkarta Therapeutics is a developer of cell engineering platform created to build the next generation of cell therapies.
Founded 2015South San Francisco, United States$240Mlast round Mar 2024 - 24
PlentyPlenty® is an American farming technology company specializing in indoor vertical farming.Plenty® is an American farming technology company specializing in indoor vertical farming.
Founded 2013South San Francisco, United States$225Mlast round May 2024 - 25
InterVennInterVenn unlocks the glycoproteome using artificial intelligence for the development of transformational healthcare solutions in DX and Rx.InterVenn unlocks the glycoproteome using artificial intelligence for the development of transformational healthcare solutions in DX and Rx.
Founded 2017South San Francisco, United States$210Mlast round Aug 2021 - 26
Soley TherapeuticsSoley Therapeutics is a biotechnology company based in South San Francisco, California, focused on drug discovery and development.Soley Therapeutics is a biotechnology company based in South San Francisco, California, focused on drug discovery and development.
Founded 2020South San Francisco, United States$200Mlast round Jan 2026 - 27
Circle PharmaCircle Pharma is a provider of a macrocycle development platform intended to provide macrocyclic peptides.Circle Pharma is a provider of a macrocycle development platform intended to provide macrocyclic peptides.
Founded 2012South San Francisco, United States$187Mlast round Sept 2026 - 28
Electra TherapeuticsElectra Therapeutics is a clinical-stage biotechnology company based in South San Francisco, California, founded in 2018.Electra Therapeutics is a clinical-stage biotechnology company based in South San Francisco, California, founded in 2018.
Founded 2018South San Francisco, United States$183Mlast round Oct 2025 - 29
Lycia TherapeuticsLycia Therapeutics is a clinical-stage biotechnology company based in South San Francisco, California.Lycia Therapeutics is a clinical-stage biotechnology company based in South San Francisco, California.
Founded 2020South San Francisco, United States$182Mlast round Jun 2026 - 30
Annexon BiosciencesAnnexon Biosciences is a biotech company, discovering and developing novel therapeutics for neurodegenerative and autoimmune disorders.Annexon Biosciences is a biotech company, discovering and developing novel therapeutics for neurodegenerative and autoimmune disorders.
Founded -South San Francisco, United States$180Mlast round Jul 2026 - 31
Day One BiopharmaceuticalsDay One Biopharmaceuticals develops targeted therapies to treat people with life-threatening diseases.Day One Biopharmaceuticals develops targeted therapies to treat people with life-threatening diseases.
Founded 2018South San Francisco, United States$175Mlast round Jul 2024 - 32
Senti BiosciencesSenti Biosciences is a biotechnology company that focuses on synthetic biology and gene circuit engineering for therapeutic applications.Senti Biosciences is a biotechnology company that focuses on synthetic biology and gene circuit engineering for therapeutic applications.
Founded 2016South San Francisco, United States$169Mlast round May 2026 - 33
SolazymeSolazyme is a synthetic biology company converting algal biomass into biofuels for the transportation, cosmetic and food industries.Solazyme is a synthetic biology company converting algal biomass into biofuels for the transportation, cosmetic and food industries.
Founded 2003South San Francisco, United States$146Mlast round Aug 2010 - 34Harpoon TherapeuticsHarpoon Therapeutics is a clinical-stage immunotherapy company focused on the development of novel T-cell recruiting biologic therapies.
Harpoon Therapeutics is a clinical-stage immunotherapy company focused on the development of novel T-cell recruiting biologic therapies.
Founded 2015South San Francisco, United States$145Mlast round Oct 2023 - 35
True North TherapeuticsTrue North Therapeutics is a pioneering biotechnology company selectively inhibiting the Complement pathway for diseases.True North Therapeutics is a pioneering biotechnology company selectively inhibiting the Complement pathway for diseases.
Founded 2013South San Francisco, United States$142Mlast round Jan 2018 - 36
Nura BioNura Bio is a clinical-stage biopharmaceutical company based in South San Francisco, California.Nura Bio is a clinical-stage biopharmaceutical company based in South San Francisco, California.
Founded 2018South San Francisco, United States$142Mlast round Jun 2026 - 37
Quince TherapeuticsQuince Therapeutics is developing treatments for Alzheimer's and other degenerative disorders.Quince Therapeutics is developing treatments for Alzheimer's and other degenerative disorders.
Founded 2012South San Francisco, United States$137Mlast round May 2026 - 38
Moonwalk BiosciencesMoonwalk Biosciences is an early-stage, pre-clinical therapeutics company based in South San Francisco, California, with an additional office in San Diego.Moonwalk Biosciences is an early-stage, pre-clinical therapeutics company based in South San Francisco, California, with an additional office in San Diego.
Founded 2022South San Francisco, United States$127Mlast round Sept 2026 - 39
Quanta TherapeuticsQuanta Therapeutics, Inc.Quanta Therapeutics, Inc.
Founded 2018South San Francisco, United States$127Mlast round Jun 2026 - 40
SonoTheraSonoThera is a biotechnology company based in South San Francisco that focuses on developing ultrasound-guided, nonviral gene therapies.SonoThera is a biotechnology company based in South San Francisco that focuses on developing ultrasound-guided, nonviral gene therapies.
Founded 2021South San Francisco, United States$125Mlast round Jun 2026 - 41
AKASAAKASA is a HealthTech company that specializes in generative AI-powered automation solutions for the healthcare revenue cycle.AKASA is a HealthTech company that specializes in generative AI-powered automation solutions for the healthcare revenue cycle.
Founded 2019South San Francisco, United States$120Mlast round Jun 2024 - 42
Hana BiosciencesTalon Therapeutics is a biopharmaceutical company develops and commercializes new and differentiated cancer therapies.Talon Therapeutics is a biopharmaceutical company develops and commercializes new and differentiated cancer therapies.
Founded 2002South San Francisco, United States$116Mlast round Jun 2010 - 43
Calithera BiosciencesCalithera Biosciences is a pharmaceutical company developing novel small molecule therapeutics for the treatment of cancer.Calithera Biosciences is a pharmaceutical company developing novel small molecule therapeutics for the treatment of cancer.
Founded 2010South San Francisco, United States$115Mlast round Mar 2022 - 44
Trace NeuroscienceLaunched in 2024, Trace Neuroscience is a biopharmaceutical company on a mission to expand the promise of genomic medicine for people living with neurodegeneratLaunched in 2024, Trace Neuroscience is a biopharmaceutical company on a mission to expand the promise of genomic medicine for people living with neurodegenerat
Founded 2024South San Francisco, United States$101Mlast round Nov 2024 - 45
Addition TherapeuticsAddition Therapeutics develops RNA-only therapeutics using PRINT technology for genetic medicine.Addition Therapeutics develops RNA-only therapeutics using PRINT technology for genetic medicine.
Founded -South San Francisco, United States$100Mlast round Dec 2025 - 46
Lyell ImmunopharmaLyell Immunopharma is an operator of a biotechnology company that develops cellular therapies to cure cancer.Lyell Immunopharma is an operator of a biotechnology company that develops cellular therapies to cure cancer.
Founded 2018South San Francisco, United States$100Mlast round Jul 2025 - 47
Genome MedicalGenome Medical is a telegenomics technology and services company allowing access to genomic-based medicine.Genome Medical is a telegenomics technology and services company allowing access to genomic-based medicine.
Founded 2016South San Francisco, United States$98Mlast round Sept 2024 - 48
Epicrispr BiotechnologiesEpicrispr Biotechnologies is a clinical-stage biotechnology company based in South San Francisco, California.Epicrispr Biotechnologies is a clinical-stage biotechnology company based in South San Francisco, California.
Founded 2018South San Francisco, United States$90Mlast round Aug 2026 - 49
Principia BioPharmaPrincipia Biopharma is dedicated to bringing oral therapies to patients with significant unmet medical needs in immunology & oncology.Principia Biopharma is dedicated to bringing oral therapies to patients with significant unmet medical needs in immunology & oncology.
Founded 2008South San Francisco, United States$90Mlast round Aug 2015 - 50
Kezar Life SciencesKezar Life Sciences company focused on the discovery and development of drugs targeting protein homeostasis for autoimmune disordersKezar Life Sciences company focused on the discovery and development of drugs targeting protein homeostasis for autoimmune disorders
Founded 2015South San Francisco, United States$85Mlast round Oct 2022
South San Francisco, United StatesEvery startup we hold in South San Francisco, ranked by the total it has raised in rounds we hold. Nobody pays to be on a list.
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