Top list · Chicago

AI startups in Chicago

45 AI startups in Chicago have raised money in rounds we track. These are the 45 that have raised the most, $912M between them.

$912Mraised by these 45
45on our record in all
Ocientraised the most
  1. 1OcientOcient is a data analytics software solutions company based in Chicago, Illinois, founded in 2016.

    Ocient is a data analytics software solutions company based in Chicago, Illinois, founded in 2016.

    Founded 2016Chicago, United States$200Mlast round Nov 2026
  2. 2ChowbusChowbus is a full-stack restaurant technology company and food delivery platform based in Chicago, Illinois.

    Chowbus is a full-stack restaurant technology company and food delivery platform based in Chicago, Illinois.

    Founded 2016Chicago, United States$105Mlast round Mar 2026
  3. 3EvozyneEvozyne is a biotechnology company based in Chicago, Illinois, focused on designing and developing innovative protein therapeutics and synthetic proteins.

    Evozyne is a biotechnology company based in Chicago, Illinois, focused on designing and developing innovative protein therapeutics and synthetic proteins.

    Founded 2020Chicago, United States$81Mlast round Sept 2023
  4. 4HealthJoyHealthJoy is a healthcare technology company based in Chicago, founded in 2014.

    HealthJoy is a healthcare technology company based in Chicago, founded in 2014.

    Founded 2014Chicago, United States$73Mlast round Oct 2022
  5. 5ThreekitThreekit is an AI-powered Visual Commerce Platform based in Chicago, Illinois.

    Threekit is an AI-powered Visual Commerce Platform based in Chicago, Illinois.

    Founded 2018Chicago, United States$65Mlast round Nov 2021
  6. 6Narrative ScienceNarrative Science creates software that writes stories from enterprise data to drive understanding and results.

    Narrative Science creates software that writes stories from enterprise data to drive understanding and results.

    Founded 2010Chicago, United States$49Mlast round Apr 2017
  7. 7Letter AILetter AI is an innovative revenue enablement platform founded in 2023 by Ali Akhtar and Armen Forget, based in Chicago, Illinois.

    Letter AI is an innovative revenue enablement platform founded in 2023 by Ali Akhtar and Armen Forget, based in Chicago, Illinois.

    Founded 2023Chicago, United States$43Mlast round Feb 2026
  8. 8Empirical SecurityEmpirical builds mathematical models for security data.

    Empirical builds mathematical models for security data.

    Founded 2024Chicago, United States$37Mlast round Jul 2026
  9. 9Hugo TechnologiesHugo Technologies offers outsourcing for customer support, e-commerce management, fraud prevention, and AI data processing.

    Hugo Technologies offers outsourcing for customer support, e-commerce management, fraud prevention, and AI data processing.

    Founded -Chicago, United States$30Mlast round Jan 2026
  10. 10PatientIQPatientIQ is a healthcare technology company based in Chicago, founded in 2016.

    PatientIQ is a healthcare technology company based in Chicago, founded in 2016.

    Founded 2016Chicago, United States$30Mlast round Sept 2026
  11. 11KeyCareKeyCare is a virtual care platform that enhances telehealth solutions for health systems using Epic's infrastructure.

    KeyCare is a virtual care platform that enhances telehealth solutions for health systems using Epic's infrastructure.

    Founded 2022Chicago, United States$29Mlast round Sept 2026
  12. 12PrenosisPrenosis Inc.

    Prenosis Inc.

    Founded 2014Chicago, United States$20Mlast round Jan 2026
  13. 13Waltz HealthWaltz Health is a new digital health company.

    Waltz Health is a new digital health company.

    Founded 2021Chicago, United States$18Mlast round Nov 2024
  14. 14NucleaiNucleai is an AI-powered spatial biology software platform focused on precision medicine.

    Nucleai is an AI-powered spatial biology software platform focused on precision medicine.

    Founded 2018Chicago, United States$14Mlast round Apr 2024
  15. 15Laconic Infrastructure PartnersLaconic Infrastructure Partners specializes in providing integrated environmental intelligence services.

    Laconic Infrastructure Partners specializes in providing integrated environmental intelligence services.

    Founded 2019Chicago, United States$12Mlast round Jun 2023
  16. 16Stately BioStately Bio is a biotechnology company based in Palo Alto, founded in 2022.

    Stately Bio is a biotechnology company based in Palo Alto, founded in 2022.

    Founded -Chicago, United States$12Mlast round May 2025
  17. 17NewityNEWITY, based in Chicago, is a fintech company founded in 2020.

    NEWITY, based in Chicago, is a fintech company founded in 2020.

    Founded 2021Chicago, United States$11Mlast round Feb 2026
  18. 18StitchStudioStitchStudio is an AI platform tailored for the insurance industry, aimed at helping carriers, brokers, managing general agents (MGAs), and third-party administ

    StitchStudio is an AI platform tailored for the insurance industry, aimed at helping carriers, brokers, managing general agents (MGAs), and third-party administ

    Founded -Chicago, United States$8.0Mlast round Nov 2026
  19. 19Technical ParadigmTechnical Paradigm is an IT staffing and recruiting agency based in Chicago, specializing in connecting businesses with qualified IT professionals.

    Technical Paradigm is an IT staffing and recruiting agency based in Chicago, specializing in connecting businesses with qualified IT professionals.

    Founded 2016Chicago, United States$7.5Mlast round Aug 2023
  20. 20QumisQumis is an AI-powered knowledge platform for complex risks.

    Qumis is an AI-powered knowledge platform for complex risks.

    Founded 2022Chicago, United States$6.5Mlast round Feb 2026
  21. 21YourcoYourco is a B2B SaaS company based in Indianapolis, Indiana, founded in 2021.

    Yourco is a B2B SaaS company based in Indianapolis, Indiana, founded in 2021.

    Founded 2021Chicago, United States$6.0Mlast round Mar 2026
  22. 22iAsk AiiAsk.Ai is an AI-powered answer engine founded in 2022 and based in Chicago, Illinois.

    iAsk.Ai is an AI-powered answer engine founded in 2022 and based in Chicago, Illinois.

    Founded 2013Chicago, United States$5.7Mlast round Feb 2024
  23. 23Sibel HealthSibel Health, Inc.

    Sibel Health, Inc.

    Founded 2018Chicago, United States$5.5Mlast round Apr 2026
  24. 24SAVVI AISavvi AI is a low-code, enterprise-grade AI platform founded in 2021 and based in Chicago, Illinois.

    Savvi AI is a low-code, enterprise-grade AI platform founded in 2021 and based in Chicago, Illinois.

    Founded 2021Chicago, United States$5.5Mlast round Sept 2023
  25. 25MondaMonda is a B2B SaaS data monetization platform founded in 2024 and headquartered in Dover, Delaware, with additional locations in Berlin and Chicago.

    Monda is a B2B SaaS data monetization platform founded in 2024 and headquartered in Dover, Delaware, with additional locations in Berlin and Chicago.

    Founded 2024Chicago, United States$5.0Mlast round Sept 2024
  26. 26ClearstepClinical-grade A.I.

    Clinical-grade A.I.

    Founded 2018Chicago, United States$4.2Mlast round Jan 2025
  27. 27ArvistArvist is a logistics technology company based in Chicago, founded in 2021.

    Arvist is a logistics technology company based in Chicago, founded in 2021.

    Founded 2022Chicago, United States$4.0Mlast round Sept 2025
  28. 28ResponsivResponsiv is a legal technology company based in Chicago, founded in 2023.

    Responsiv is a legal technology company based in Chicago, founded in 2023.

    Founded 2023Chicago, United States$3.0Mlast round Nov 2023
  29. 29ClassetClasset is a Chicago-based AI-powered recruiting platform that simplifies the hiring process for skilled trades and blue-collar workers across the United States.

    Classet is a Chicago-based AI-powered recruiting platform that simplifies the hiring process for skilled trades and blue-collar workers across the United States.

    Founded 2021Chicago, United States$3.0Mlast round Dec 2022
  30. 30MahaloMahalo is an AI-powered post-purchase experience platform designed to help manufacturers with warranty management and customer interactions.

    Mahalo is an AI-powered post-purchase experience platform designed to help manufacturers with warranty management and customer interactions.

    Founded -Chicago, United States$2.6Mlast round Jun 2025
  31. 31SafeHillSafeHill is an AI-powered cybersecurity SaaS company based in Chicago, Illinois, specializing in Continuous Threat Exposure Management (CTEM).

    SafeHill is an AI-powered cybersecurity SaaS company based in Chicago, Illinois, specializing in Continuous Threat Exposure Management (CTEM).

    Founded 2025Chicago, United States$2.6Mlast round Sept 2025
  32. 32Nimblemind.aiNimblemind.ai is a healthcare technology company based in Chicago, founded in 2024.

    Nimblemind.ai is a healthcare technology company based in Chicago, founded in 2024.

    Founded 2024Chicago, United States$2.5Mlast round Mar 2025
  33. 33HeretikHeretik is a legal technology company based in Chicago, founded in 2016.

    Heretik is a legal technology company based in Chicago, founded in 2016.

    Founded 2016Chicago, United States$2.4Mlast round Jan 2020
  34. 34Force EqualsForce Equals is a startup based in Tampa, Florida, founded in 2025.

    Force Equals is a startup based in Tampa, Florida, founded in 2025.

    Founded 2024Chicago, United States$2.2Mlast round Feb 2026
  35. 35The CollaboratoryThe Collaboratory is a Chicago-based AI company founded in 2020.

    The Collaboratory is a Chicago-based AI company founded in 2020.

    Founded 2020Chicago, United States$1.6Mlast round Apr 2022
  36. 36BrighthiveBrighthive is a Chicago-based AI startup founded in 2018 that offers an agentic data operations (DataOps) platform.

    Brighthive is a Chicago-based AI startup founded in 2018 that offers an agentic data operations (DataOps) platform.

    Founded 2021Chicago, United States$1.3Mlast round Jul 2019
  37. 37ConceptDropConceptDrop matches brands with an invite-only community of creative professionals.

    ConceptDrop matches brands with an invite-only community of creative professionals.

    Founded 2012Chicago, United States$1.3Mlast round May 2016
  38. 38RepIQFree email tracking for Gmail.

    Free email tracking for Gmail.

    Founded 2016Chicago, United States$1.1Mlast round Jul 2017
  39. 39DigsFactDigsFact is an AI-driven software company based in Crystal Lake, Illinois, founded in 2018.

    DigsFact is an AI-driven software company based in Crystal Lake, Illinois, founded in 2018.

    Founded 2018Chicago, United States$1.0Mlast round Mar 2024
  40. 40Blip EnergyBlip is building a drop-in distributed energy resource to mitigate surging demand, optimize user costs and reduce utility operating costs.

    Blip is building a drop-in distributed energy resource to mitigate surging demand, optimize user costs and reduce utility operating costs.

    Founded -Chicago, United States$500Klast round Nov 2024
  41. 41GLCTC CorpGLCTC Corp is a technology company that focuses on creating the next generation of software and hardware.

    GLCTC Corp is a technology company that focuses on creating the next generation of software and hardware.

    Founded 2018Chicago, United States$300Klast round Jun 2024
  42. 42VerbosoVerboso develops an open-source database of impaired speech sounds for children.

    Verboso develops an open-source database of impaired speech sounds for children.

    Founded 2018Chicago, United States$250Klast round Aug 2021
  43. 43TRaiCETRaiCE is an AI-based early warning business risk detection and monitoring system for lenders and investors.

    TRaiCE is an AI-based early warning business risk detection and monitoring system for lenders and investors.

    Founded 2021Chicago, United States$200Klast round Dec 2023
  44. 44Iris Light TechnologiesIris Light Technologies is a Chicago-based company specializing in nanotechnology and silicon photonics.

    Iris Light Technologies is a Chicago-based company specializing in nanotechnology and silicon photonics.

    Founded 2018Chicago, United States$120Klast round Sept 2023
  45. 45SupplyHiveSupplyHiveTM is a Chicago-based enterprise software company founded in 2018, specializing in Supplier Performance Management (SPM) and Supplier Relationship Man

    SupplyHiveTM is a Chicago-based enterprise software company founded in 2018, specializing in Supplier Performance Management (SPM) and Supplier Relationship Man

    Founded 2018Chicago, United States$10Klast round Dec 2022
Total fundinghow the list is ranked
15 November 2026updated nightly
Rounds we tracksource: Millionrounds

Companies whose funding rounds we classed as any of these sectors, ranked by the total they have raised in rounds we hold. Nobody pays to be on a list.

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