Portfolio map · VC firm · United States
Two Sigma Ventures portfolio map
51 startups Two Sigma Ventures has backed in rounds we track, since 2013, grouped by their main sector. Together they have raised $86B; Two Sigma Ventures led at least one round in 3 of them. The biggest sector is AI, with 18 companies.
51startups backed
8sectors
$86Braised between them
AIbiggest sector
AI
18
Funding by segment
- AI$82B18
- Biotech$1.3B8
- Fintech$300M8
- Big Data & Analytics$79M5
- Healthtech$1.5B3
- Cybersecurity$326M3
- Internet$68M3
- Cloud$234M3
Where they are based
- United States47$86B
- Mexico1$200M
- Puerto Rico1$150K
- United Kingdom1$8.0M
United States
Mexico
Puerto Rico
United KingdomFounded
3Earlier
312
313
314
415
16
517
418
619
620
421
122
223
24
25
26
7 without a founding year on record.
Total raised
- Under $1M1
- $1M to $10M7
- $10M to $50M18
- $50M to $250M18
- $250M to $1B5
- $1B and over2
Each dot is a startup: the year it was founded across, the total it has raised up (each line is ten times the one below). Pick a segment to pick it out.
44 of 51 startups shown; the rest have no founding year or amount on record.
- 1 to 2
- 3 to 7
- 8 to 24
- 25 to 99
- 100 and more
- United States47
- Mexico1
- Puerto Rico1
- United Kingdom1
Startups by country, 4 countries in all.
Segment by segment
AI
18 startups · $82B raised
xAIUnited States$81B
EnvedaEnveda Biosciences is a clinical-stage biotechnology company founded in 2019, focused on accelerating drug discovery through an AIUnited States$461M
SocureSocure is a prominent American technology company that specializes in AI-driven digital identity verification, fraud prevention, aUnited States$273M- RRADARUnited States$269M
AnkiUnited States$158M
Terray TherapeuticsTerray Therapeutics is a biotechnology company that propels drug discovery into the information age.United States$145M
ArtemisArtemis operates an intelligence platform for indoor farms.United States$79M
OsmoOsmo is an AI-powered olfactory intelligence company founded in 2022, specializing in digitizing smell.United States$73M
Biotech
8 startups · $1.3B raised
ZymergenUnited States$874M
Cajal NeuroscienceCajal Neuroscience is a drug discovery company focused on neurodegenerative disease.United States$96M
KallyopeKallyope uses the science of gut-brain biology to create medicines that transform human health.United States$95M
Hexagon BioHexagon Bio is a biopharmaceutical company based in Menlo Park, California, founded in 2016.United States$77M
Exai BioExai Bio is a biotechnology company based in Palo Alto, California, founded in 2021.United States$68M
Appia BioAppia Bio was a biotechnology company founded in 2020 and based in Culver City, California.United States$52M
Arda TherapeuticsArda Therapeutics is a biotechnology company based in the San Francisco Bay Area, founded in 2021.United States$43M
Isabl Inc.Isabl develops cancer diagnostic tests based on whole genome and RNA sequencing data.United States$2.0M
Fintech
8 startups · $300M raised
NeloNelo increases the buying power for consumers in LatAm.Mexico$200M
HighbeamHighbeam is a financial technology company based in New York, founded in 2021.United States$30M
Membrane LabsMembrane Labs is a fintech company established in 2019, specializing in digital asset credit infrastructure and prime services forUnited States$20M
Ansel HealthAnsel Health is a developer of a health insurance platform intended for employers to enhance their employee benefits.United States$20M
agenteroAgentero is an InsurTech and FinTech company founded in 2017 and based in Oakland, California.United States$14M
RightRevRightRev is a financial technology and enterprise software company founded in 2020 by Jagan Reddy, based in Santa Clara, CaliforniUnited States$13M
MonetizeNowMonetizeNow is the World's First Unified CPQ, Billing and Usage Platform Built For B2B SaaSUnited States$3.0M
RaincoatRaincoat is a technology company that creates an operating system designed to connect insurance providers, reinsurers, distributorPuerto Rico$150K
Big Data & Analytics
5 startups · $79M raised
InsightSquaredInsightSquared is a revenue intelligence platform that provides sales intelligence solutions for forecasting, accuracy, and decision-making.United States$50M
AnomaloAnomalo is a Palo Alto-based company founded in 2018 that specializes in AI-powered data quality and observability.United States$10M
SDFSDF is a compiler and build system that leverages static analysis to comprehensively examine SQL code at a warehouse scale.United States$9.0M
Switchboard SoftwareSwitchboard Software is an enterprise-grade data engineering automation platform founded in 2013 and based in San Francisco, California.United States$7.0M
CanduCandu is a product experience platform for software teams who want to design, refine, and personalize their application’s user interface.United States$3.0M
Healthtech
3 startups · $1.5B raised
WHOOPWHOOP is a performance optimization system that tracks athlete recovery, training, and sleeping hours to help boost performance.United States$1.3B
CanaryCanary is the first partner of choice of the best founders in LatAm.United States$177M
Carbon HealthCarbon Health is a technology-enabled chain of primary and urgent care clinics founded in 2015 in San Francisco.United States$56M
Cybersecurity
3 startups · $326M raised
SecurityScorecardSecurityScorecard is a leader in cybersecurity ratings and third-party risk management, providing AI-driven solutions for continuoUnited States$278M
CerbyCerby is an identity automation platform founded in 2020 and based in Alameda, California.United States$40M
TrustologyTrustology is building a custody platform to safeguard your crypto assets.United Kingdom$8.0M
Internet
3 startups · $68M raised
Pro.comTiberius in a letter to him saith, Haec pro amicitia nostra non occultavi; and the whole senate dedicated an altar to Friendship, United States$51M
PlacedPlaced is a location-driven insights and mobile ad intelligence platform that provides reports on consumers’ offline behaviors.United States$13M
Spruce UpSpruce Up from a product to a brand A fresh new perspective can change everything about a brand.United States$4.5M
Cloud
3 startups · $234M raised
D2iqD2iQ offers elastically run containers and data services at scale, with complete hybrid cloud portability.-$125M
ReplicatedReplicated is a technology company based in Los Angeles, specializing in software distribution for self-hosted and enterprise environments.United States$57M
FlatfileThe Flatfile Data Exchange Platform is the easiest, fastest, and safest way for developers to build the ideal data file import experience.United States$52M
How this map is made. Every startup here has raised money in a round we track that names Two Sigma Ventures as an investor, the first in 2013. Each sits under its main sector, read from its rounds, and each sector shows its best-funded first; sectors with fewer than three companies are left off. Rebuilt nightly; updated 15 November 2026.
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