# Top 50 Startups in San Mateo by Funding (2026)

> The 50 best-funded startups in San Mateo, ranked by total funding raised: $16B combined. With founding year, headquarters and each company's rounds.

Source: https://millionrounds.com/top-lists/startups-san-mateo (Millionrounds; every figure on the page links to its filing or article)

- 1 [**Snowflake** Snowflake is a cloud data platform that provides a data warehouse as a service designed for the cloud.](https://millionrounds.com/company/snowflake) Snowflake is a cloud data platform that provides a data warehouse as a service designed for the cloud. *Founded* 2012 San Mateo, United States **$4.6B** last round Sept 2026
- 2 [**Fireworks AI** Fireworks AI is a generative AI infrastructure platform that specializes in delivering fast inference and full-parameter training for open-source AI models.](https://millionrounds.com/company/fireworks-ai) Fireworks AI is a generative AI infrastructure platform that specializes in delivering fast inference and full-parameter training for open-source AI models. *Founded* 2022 San Mateo, United States **$1.7B** last round Oct 2026
- 3 [**Upstart** Upstart connects millions of consumers to 100+ banks and credit unions who leverage Upstart's artificial intelligence models and cloud applications to deliver s](https://millionrounds.com/company/upstart) Upstart connects millions of consumers to 100+ banks and credit unions who leverage Upstart's artificial intelligence models and cloud applications to deliver s *Founded* - San Mateo, United States **$1.6B** last round Apr 2026
- 4 [**Verkada** Verkada Inc.](https://millionrounds.com/company/verkada) Verkada Inc. *Founded* 2016 San Mateo, United States **$1.6B** last round Jul 2026
- 5 [**SiFive** SiFive is a platform offering open-source semiconductor technology and software automation.](https://millionrounds.com/company/sifive) SiFive is a platform offering open-source semiconductor technology and software automation. *Founded* 2015 San Mateo, United States **$700M** last round Apr 2026
- 6 [**Alpaca** Alpaca is a brokerage infrastructure company based in San Mateo, California, that specializes in providing an API-first platform for commission-free trading.](https://millionrounds.com/company/alpaca) Alpaca is a brokerage infrastructure company based in San Mateo, California, that specializes in providing an API-first platform for commission-free trading. *Founded* 2017 San Mateo, United States **$513M** last round Jul 2026
- 7 [**Skydio** Skydio is a leading U.S.](https://millionrounds.com/company/skydio) Skydio is a leading U.S. *Founded* 2014 San Mateo, United States **$350M** last round Apr 2026
- 8 [**Cloudian** Cloudian is a file and object storage company that provides hybrid cloud data management software.](https://millionrounds.com/company/cloudian) Cloudian is a file and object storage company that provides hybrid cloud data management software. *Founded* 2011 San Mateo, United States **$324M** last round Jun 2024
- 9 [**Reali** Reali was a real estate and fintech company that operated a digital platform to simplify the homeownership journey.](https://millionrounds.com/company/reali) Reali was a real estate and fintech company that operated a digital platform to simplify the homeownership journey. *Founded* 2016 San Mateo, United States **$240M** last round Aug 2021
- 10 [**Generalist** Generalist, also known as Generalist AI, is a robotics company based in San Mateo, California, with a mission to develop general-purpose robots that can operate](https://millionrounds.com/company/generalist) Generalist, also known as Generalist AI, is a robotics company based in San Mateo, California, with a mission to develop general-purpose robots that can operate *Founded* 2024 San Mateo, United States **$200M** last round Aug 2026
- 11 [**Bluejay Therapeutics** Bluejay Therapeutics is a private biopharmaceutical company focused on the development of cures for infectious diseases.](https://millionrounds.com/company/bluejay-therapeutics) Bluejay Therapeutics is a private biopharmaceutical company focused on the development of cures for infectious diseases. *Founded* 2019 San Mateo, United States **$182M** last round May 2024
- 12 [**SnapLogic** SnapLogic is a software company that provides a platform for enterprise cloud and big data integration.](https://millionrounds.com/company/snaplogic) SnapLogic is a software company that provides a platform for enterprise cloud and big data integration. *Founded* 2006 San Mateo, United States **$171M** last round Oct 2019
- 13 [**Observe** Observe offers an observability cloud solution to accelerate the transformation of troubleshooting applications and resolving incidents.](https://millionrounds.com/company/observe) Observe offers an observability cloud solution to accelerate the transformation of troubleshooting applications and resolving incidents. *Founded* 2017 San Mateo, United States **$156M** last round Jul 2025
- 14 [**Luma Health** Luma Health is a healthcare technology company founded in 2015 and based in San Mateo, California.](https://millionrounds.com/company/luma-health) Luma Health is a healthcare technology company founded in 2015 and based in San Mateo, California. *Founded* 2015 San Mateo, United States **$152M** last round Nov 2021
- 15 [**BigHat Biosciences** BigHat Biosciences is a biotechnology company founded in 2019 and based in San Mateo, California.](https://millionrounds.com/company/bighat-biosciences) BigHat Biosciences is a biotechnology company founded in 2019 and based in San Mateo, California. *Founded* 2019 San Mateo, United States **$150M** last round Sept 2026
- 16 [**Cala Health** Cala Health is a bioelectronic medicine company based in San Mateo, California, founded in 2013.](https://millionrounds.com/company/cala-health) Cala Health is a bioelectronic medicine company based in San Mateo, California, founded in 2013. *Founded* 2014 San Mateo, United States **$150M** last round Apr 2026
- 17 [**Notable** Notable is an AI-powered health start-up that automates and digitizes every physician-patient interaction.](https://millionrounds.com/company/notable) Notable is an AI-powered health start-up that automates and digitizes every physician-patient interaction. *Founded* 2017 San Mateo, United States **$145M** last round Jul 2026
- 18 [**vArmour** VArmour offers data defined perimeter security solutions for mobile, virtual, and cloud platforms.](https://millionrounds.com/company/varmour) VArmour offers data defined perimeter security solutions for mobile, virtual, and cloud platforms. *Founded* 2011 San Mateo, United States **$144M** last round Feb 2021
- 19 [**Motif Investing** Motif Investing was an online brokerage platform founded in June 2010 by Hardeep Walia and Tariq Hilaly, based in San Mateo, California.](https://millionrounds.com/company/motif-investing) Motif Investing was an online brokerage platform founded in June 2010 by Hardeep Walia and Tariq Hilaly, based in San Mateo, California. *Founded* 2010 San Mateo, United States **$127M** last round Jan 2015
- 20 [**Tile** Tile, Inc.](https://millionrounds.com/company/tile) Tile, Inc. *Founded* 2012 San Mateo, United States **$126M** last round Apr 2024
- 21 [**SendBird** Sendbird is a global communications platform and a leading provider of Communications Platform as a Service (CPaaS) solutions.](https://millionrounds.com/company/sendbird) Sendbird is a global communications platform and a leading provider of Communications Platform as a Service (CPaaS) solutions. *Founded* 2013 San Mateo, United States **$118M** last round Jan 2022
- 22 [**AusperBio** AusperBio is a clinical-stage biopharmaceutical company dedicated to advancing treatments for hepatitis B virus (HBV) and developing oligonucleotide therapeutics.](https://millionrounds.com/company/ausperbio) AusperBio is a clinical-stage biopharmaceutical company dedicated to advancing treatments for hepatitis B virus (HBV) and developing oligonucleotide therapeutics. *Founded* 2019 San Mateo, United States **$113M** last round Sept 2025
- 23 [**Zinier** Zinier is a privately held company based in San Mateo, California, specializing in AI-native field service management (FSM) software.](https://millionrounds.com/company/zinier) Zinier is a privately held company based in San Mateo, California, specializing in AI-native field service management (FSM) software. *Founded* 2018 San Mateo, United States **$112M** last round Jan 2020
- 24 [**CARGO Therapeutics** CARGO Therapeutics develops an adoptive cell therapy to benefit patients from potentially curative treatment options.](https://millionrounds.com/company/cargo-therapeutics) CARGO Therapeutics develops an adoptive cell therapy to benefit patients from potentially curative treatment options. *Founded* 2019 San Mateo, United States **$110M** last round May 2024
- 25 [**Netomi** Netomi is an American artificial intelligence company that specializes in agentic AI solutions for customer experience and service.](https://millionrounds.com/company/netomi) Netomi is an American artificial intelligence company that specializes in agentic AI solutions for customer experience and service. *Founded* 2016 San Mateo, United States **$110M** last round May 2026
- 26 [**Calysta** Calysta is a biotechnology company based in California, specializing in cellular agriculture.](https://millionrounds.com/company/calysta) Calysta is a biotechnology company based in California, specializing in cellular agriculture. *Founded* 2011 San Mateo, United States **$109M** last round Mar 2021
- 27 [**EpiBiologics** EpiBiologics is a biotechnology company based in San Mateo, California, founded in 2022.](https://millionrounds.com/company/epibiologics) EpiBiologics is a biotechnology company based in San Mateo, California, founded in 2022. *Founded* 2022 San Mateo, United States **$107M** last round Jan 2026
- 28 [**Talend** Talend specializes in cloud data integration and data integrity.](https://millionrounds.com/company/talend) Talend specializes in cloud data integration and data integrity. *Founded* 2004 San Mateo, United States **$102M** last round Dec 2013
- 29 [**Beauty for all industries** Beauty for all industries is a powerhouse in beauty innovation.](https://millionrounds.com/company/beauty-for-all-industries) Beauty for all industries is a powerhouse in beauty innovation. *Founded* 2020 San Mateo, United States **$96M** last round Feb 2022
- 30 [**Explorium** Explorium is a B2B data technology company founded in 2017, headquartered in Tel Aviv, Israel, with additional offices in San Mateo, California, and Lehi, Utah.](https://millionrounds.com/company/explorium) Explorium is a B2B data technology company founded in 2017, headquartered in Tel Aviv, Israel, with additional offices in San Mateo, California, and Lehi, Utah. *Founded* 2017 San Mateo, United States **$94M** last round May 2021
- 31 [**Kivu Bioscience** As a company focused on rapidly advancing next generation transformative assets, we leverage our expertise to efficiently progress programs to clinical proof of concept.](https://millionrounds.com/company/kivu-bioscience) As a company focused on rapidly advancing next generation transformative assets, we leverage our expertise to efficiently progress programs to clinical proof of concept. *Founded* 2024 San Mateo, United States **$92M** last round Oct 2024
- 32 [**Edmodo** Edmodo is a global education network that connects all learners with the people and resources they need to reach their full potential.](https://millionrounds.com/company/edmodo) Edmodo is a global education network that connects all learners with the people and resources they need to reach their full potential. *Founded* 2008 San Mateo, United States **$88M** last round Aug 2014
- 33 [**Conversica** Conversica creates intelligent virtual assistants to serve as virtual team members.](https://millionrounds.com/company/conversica) Conversica creates intelligent virtual assistants to serve as virtual team members. *Founded* 2007 San Mateo, United States **$84M** last round Oct 2018
- 34 [**Neo4j** Neo4j is a global leader in graph intelligence, recognized for its Neo4j Graph Database, a native graph database management system.](https://millionrounds.com/company/neo4j) Neo4j is a global leader in graph intelligence, recognized for its Neo4j Graph Database, a native graph database management system. *Founded* 2007 San Mateo, United States **$80M** last round Nov 2018
- 35 [**Salma Health** Salma Health is a comprehensive brain health clinic combining advanced diagnostics, personalized treatment and continuous care under one roof.](https://millionrounds.com/company/salma-health) Salma Health is a comprehensive brain health clinic combining advanced diagnostics, personalized treatment and continuous care under one roof. *Founded* 2016 San Mateo, United States **$80M** last round Feb 2026
- 36 [**Wonder Workshop** Wonder Workshop provides a platform that makes programming fun and accessible for children while they play.](https://millionrounds.com/company/wonder-workshop) Wonder Workshop provides a platform that makes programming fun and accessible for children while they play. *Founded* 2012 San Mateo, United States **$78M** last round Oct 2017
- 37 [**Yellow.ai** Yellow.ai is a conversational AI platform, enabling enterprises to unlock business potential at scale.](https://millionrounds.com/company/yellow-ai) Yellow.ai is a conversational AI platform, enabling enterprises to unlock business potential at scale. *Founded* 2016 San Mateo, United States **$78M** last round Aug 2021
- 38 [**Arkose Labs** Arkose Labs is a global leader in proactive fraud deterrence and account security, based in San Mateo, California.](https://millionrounds.com/company/arkose-labs) Arkose Labs is a global leader in proactive fraud deterrence and account security, based in San Mateo, California. *Founded* 2016 San Mateo, United States **$76M** last round May 2021
- 39 [**Vivace Therapeutics** Vivace Therapeutics is a venture-backed start-up dedicated to discovering and developing cancer therapeutics by targeting a novel pathway.](https://millionrounds.com/company/vivace-therapeutics) Vivace Therapeutics is a venture-backed start-up dedicated to discovering and developing cancer therapeutics by targeting a novel pathway. *Founded* 2014 San Mateo, United States **$75M** last round Mar 2025
- 40 [**icix** ICIX enables real-time coordination across supply chain and trading partner networks to manage sourcing, sustainability, safety and go-to-market initiatives.](https://millionrounds.com/company/icix) ICIX enables real-time coordination across supply chain and trading partner networks to manage sourcing, sustainability, safety and go-to-market initiatives. *Founded* 2004 San Mateo, United States **$75M** last round Jan 2017
- 41 [**Swing Education** Swing Education is a technology-driven substitute staffing platform founded in 2015.](https://millionrounds.com/company/swing-education) Swing Education is a technology-driven substitute staffing platform founded in 2015. *Founded* 2015 San Mateo, United States **$73M** last round Jul 2025
- 42 [**WisdomAI** WisdomAI is a private AI and data analytics company based in San Mateo, California, founded in 2023.](https://millionrounds.com/company/wisdomai) WisdomAI is a private AI and data analytics company based in San Mateo, California, founded in 2023. *Founded* 2023 San Mateo, United States **$73M** last round Nov 2025
- 43 [**Mode** MODE is driven to help organizations leverage their data to improve operations, safety, & efficiencies through the use of IoT & AI](https://millionrounds.com/company/mode) MODE is driven to help organizations leverage their data to improve operations, safety, & efficiencies through the use of IoT & AI *Founded* 2014 San Mateo, United States **$70M** last round Apr 2026
- 44 [**Kaon** AI Personalized Content Media](https://millionrounds.com/company/kaon) AI Personalized Content Media *Founded* - San Mateo, United States **$70M** last round Jul 2026
- 45 [**Sonitus Medical** Sonitus Medical provides clinically effective non-invasive and removable hearing solutions based on the bone conduction method.](https://millionrounds.com/company/sonitus-medical) Sonitus Medical provides clinically effective non-invasive and removable hearing solutions based on the bone conduction method. *Founded* 2006 San Mateo, United States **$68M** last round Apr 2014
- 46 [**BriteCore** BriteCore is a cloud-native core insurance platform tailored for Property & Casualty (P&C) insurers.](https://millionrounds.com/company/britecore) BriteCore is a cloud-native core insurance platform tailored for Property & Casualty (P&C) insurers. *Founded* 2009 San Mateo, United States **$68M** last round Sept 2021
- 47 [**Rockset** Rockset is a real-time indexing database that enables companies to build data applications for the cloud.](https://millionrounds.com/company/rockset) Rockset is a real-time indexing database that enables companies to build data applications for the cloud. *Founded* 2016 San Mateo, United States **$66M** last round Aug 2023
- 48 [**Helicore Biopharma** Helicore Biopharma is a private biopharmaceutical company based in San Mateo, California, focused on developing innovative weight-loss therapeutics and treatmen](https://millionrounds.com/company/helicore-biopharma) Helicore Biopharma is a private biopharmaceutical company based in San Mateo, California, focused on developing innovative weight-loss therapeutics and treatmen *Founded* 2025 San Mateo, United States **$65M** last round Jan 2025
- 49 [**B-Stock** B-Stock is the largest B2B recommerce platform, providing a technology-driven marketplace for businesses to purchase returned, excess, trade-in, and overstock i](https://millionrounds.com/company/b-stock) B-Stock is the largest B2B recommerce platform, providing a technology-driven marketplace for businesses to purchase returned, excess, trade-in, and overstock i *Founded* 2008 San Mateo, United States **$65M** last round Jun 2018
- 50 [**Lattice Engines** Lattice Engines specializes in the fields of marketing, sales, data-driven business applications, and trigger events.](https://millionrounds.com/company/lattice-engines) Lattice Engines specializes in the fields of marketing, sales, data-driven business applications, and trigger events. *Founded* 2006 San Mateo, United States **$65M** last round Jun 2015

**Total funding** how the list is ranked

**15 November 2026** updated nightly

**Rounds we track** source: Millionrounds

Every startup we hold in San Mateo, ranked by the total it has raised in rounds we hold. Nobody pays to be on a list.

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## More startup lists

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[*O* *A* *X* **Startups in the United States** 42,176 companies · $870B](https://millionrounds.com/top-lists/startups-united-states)[*SC* *N* *F* **Startups in the United Kingdom** 8,355 companies · $79B](https://millionrounds.com/top-lists/startups-united-kingdom)[*O* *D* *TM* **Startups in San Francisco** 4,251 companies · $350B](https://millionrounds.com/top-lists/startups-san-francisco)[*W* *K* *P* **Startups in New York** 3,729 companies · $67B](https://millionrounds.com/top-lists/startups-new-york)[*F* *IL* *PD* **Startups in London** 3,521 companies · $51B](https://millionrounds.com/top-lists/startups-london)[*MA* *M* *TE* **Startups in France** 3,025 companies · $32B](https://millionrounds.com/top-lists/startups-france)[*C* *H8* *AP* **Startups in Canada** 2,950 companies · $38B](https://millionrounds.com/top-lists/startups-canada)[*B* *D* *AF* **Startups in China** 2,168 companies · $163B](https://millionrounds.com/top-lists/startups-china)

## More lists for San Mateo

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[*S* *FA* *U* **AI startups in San Mateo** 48 companies · $12B](https://millionrounds.com/top-lists/ai-startups-san-mateo)[*I* *B* *S* **IT Services startups in San Mateo** 32 companies · $410M](https://millionrounds.com/top-lists/it-services-startups-san-mateo)[*S* *C* *S* **Big Data & Analytics startups in San Mateo** 29 companies · $6.1B](https://millionrounds.com/top-lists/big-data-startups-san-mateo)[*BT* *LH* *BB* **Biotech startups in San Mateo** 22 companies · $1.5B](https://millionrounds.com/top-lists/biotech-startups-san-mateo)[*FA* *O* *T* **Software startups in San Mateo** 22 companies · $2.4B](https://millionrounds.com/top-lists/software-startups-san-mateo)[*LH* *CH* *N* **Healthcare startups in San Mateo** 19 companies · $939M](https://millionrounds.com/top-lists/healthcare-startups-san-mateo)[*R* *T* *N* **Internet startups in San Mateo** 11 companies · $504M](https://millionrounds.com/top-lists/internet-startups-san-mateo)[*V* *V* *AL* **Cybersecurity startups in San Mateo** 10 companies · $1.9B](https://millionrounds.com/top-lists/cybersecurity-startups-san-mateo)