# Top 50 Startups in Durham by Funding (2026) > The 50 best-funded startups in Durham, ranked by total funding raised: $6.9B combined. With founding year, headquarters and each company's rounds. Source: https://millionrounds.com/top-lists/startups-durham (Millionrounds; every figure on the page links to its filing or article) - 1 [**Cypress Creek Renewables** Cypress Creek Renewables is a national provider of local solar.](https://millionrounds.com/company/cypress-creek-renewables) Cypress Creek Renewables is a national provider of local solar. *Founded* 2014 Durham, United States **$3.5B** last round Jun 2026 - 2 [**Bioventus** Bioventus delivers clinically proven, cost-effective products that help people heal quickly and safely.](https://millionrounds.com/company/bioventus) Bioventus delivers clinically proven, cost-effective products that help people heal quickly and safely. *Founded* - Durham, United States **$412M** last round Jul 2025 - 3 [**Avalara** Avalara is a cloud-based platform that provides tax compliance software and automated solutions.](https://millionrounds.com/company/avalara) Avalara is a cloud-based platform that provides tax compliance software and automated solutions. *Founded* 2004 Durham, United States **$329M** last round Sept 2016 - 4 [**Strata Clean Energy** Strata Clean Energy is a solar storage developer.](https://millionrounds.com/company/strata-clean-energy) Strata Clean Energy is a solar storage developer. *Founded* 2008 Durham, United States **$300M** last round Nov 2023 - 5 [**Humacyte** Humacyte, Inc.](https://millionrounds.com/company/humacyte) Humacyte, Inc. *Founded* 2004 Durham, United States **$297M** last round Mar 2018 - 6 [**Heelstone Renewable Energy** Heelstone Energy is a leading independent power producer and solar developer with expertise in developing, financing, constructing.](https://millionrounds.com/company/heelstone-renewable-energy) Heelstone Energy is a leading independent power producer and solar developer with expertise in developing, financing, constructing. *Founded* 2012 Durham, United States **$200M** last round Jan 2026 - 7 [**Higharc** Higharc is a cloud-based Homebuilding Intelligence platform founded in 2018 by CEO Marc Minor in Durham, NC.](https://millionrounds.com/company/higharc) Higharc is a cloud-based Homebuilding Intelligence platform founded in 2018 by CEO Marc Minor in Durham, NC. *Founded* 2018 Durham, United States **$169M** last round Jun 2026 - 8 [**Atsena Therapeutics** Atsena Therapeutics is a clinical-stage gene therapy company based in Durham, North Carolina, focused on developing treatments for inherited retinal diseases (I](https://millionrounds.com/company/atsena-therapeutics) Atsena Therapeutics is a clinical-stage gene therapy company based in Durham, North Carolina, focused on developing treatments for inherited retinal diseases (I *Founded* 2019 Durham, United States **$150M** last round Apr 2025 - 9 [**Restor3d** restor3d is a medical device company based in Durham, North Carolina, specializing in additive manufacturing for orthopedics.](https://millionrounds.com/company/restor3d) restor3d is a medical device company based in Durham, North Carolina, specializing in additive manufacturing for orthopedics. *Founded* 2017 Durham, United States **$104M** last round Aug 2025 - 10 [**SMART WIRES** Smart Wires is a grid solutions company that offers monitoring and power flow control in meshed networks.](https://millionrounds.com/company/smart-wires) Smart Wires is a grid solutions company that offers monitoring and power flow control in meshed networks. *Founded* 2010 Durham, United States **$104M** last round Jan 2025 - 11 [**ServiceTrade** ServiceTrade offers mobile and web apps for maintenance businesses to deliver more service calls and connect with their customers.](https://millionrounds.com/company/servicetrade) ServiceTrade offers mobile and web apps for maintenance businesses to deliver more service calls and connect with their customers. *Founded* 2012 Durham, United States **$90M** last round Dec 2021 - 12 [**Spreedly** Spreedly is a global open payments orchestration platform based in Durham, North Carolina.](https://millionrounds.com/company/spreedly) Spreedly is a global open payments orchestration platform based in Durham, North Carolina. *Founded* 2008 Durham, United States **$80M** last round Nov 2019 - 13 [**Kevel** Kevel, Inc.](https://millionrounds.com/company/kevel) Kevel, Inc. *Founded* 2010 Durham, United States **$75M** last round Oct 2026 - 14 [**Areteia Therapeutics** Areteia Therapeutics, Inc.](https://millionrounds.com/company/areteia-therapeutics) Areteia Therapeutics, Inc. *Founded* 2022 Durham, United States **$75M** last round Feb 2024 - 15 [**Phononic** Phononic develops thermoelectric chips designed to offer an alternative to compressor technology and traditional methods of refrigeration.](https://millionrounds.com/company/phononic) Phononic develops thermoelectric chips designed to offer an alternative to compressor technology and traditional methods of refrigeration. *Founded* 2008 Durham, United States **$70M** last round Nov 2016 - 16 [**JupiterOne** JupiterOne is a cloud-native cybersecurity platform that specializes in Cyber Asset Attack Surface Management (CAASM).](https://millionrounds.com/company/jupiterone) JupiterOne is a cloud-native cybersecurity platform that specializes in Cyber Asset Attack Surface Management (CAASM). *Founded* 2018 Durham, United States **$70M** last round Jun 2022 - 17 [**Baebies** Baebies is a medical device company based in Durham, North Carolina, focused on improving newborn screening and pediatric testing through innovative digital mic](https://millionrounds.com/company/baebies) Baebies is a medical device company based in Durham, North Carolina, focused on improving newborn screening and pediatric testing through innovative digital mic *Founded* 2014 Durham, United States **$70M** last round May 2022 - 18 [**PowerSecure International** PowerSecure International provides utility and energy technologies to electric utilities and their industrial and commercial customers.](https://millionrounds.com/company/powersecure-international) PowerSecure International provides utility and energy technologies to electric utilities and their industrial and commercial customers. *Founded* 1991 Durham, United States **$65M** last round Sept 2015 - 19 [**Idera Pharmaceuticals** Idera Pharmaceuticals merged with Aceragen, Inc., a rare disease biopharmaceutical company, in September 2022.](https://millionrounds.com/company/idera-pharmaceuticals) Idera Pharmaceuticals merged with Aceragen, Inc., a rare disease biopharmaceutical company, in September 2022. *Founded* 1989 Durham, United States **$54M** last round Feb 2014 - 20 [**Ribometrix** Ribometrix is a platform therapeutics company that discovers small molecule drugs to treat human diseases.](https://millionrounds.com/company/ribometrix) Ribometrix is a platform therapeutics company that discovers small molecule drugs to treat human diseases. *Founded* 2014 Durham, United States **$45M** last round Sept 2019 - 21 [**Digitalsmiths** Digitalsmiths connects consumers to relevant video content through personalized search, recommendations, and discovery.](https://millionrounds.com/company/digitalsmiths) Digitalsmiths connects consumers to relevant video content through personalized search, recommendations, and discovery. *Founded* 2006 Durham, United States **$38M** last round Feb 2014 - 22 [**Scioderm** Scioderm, a clinical stage pharmaceutical company, develops topical products for the treatment of chronic skin diseases.](https://millionrounds.com/company/scioderm) Scioderm, a clinical stage pharmaceutical company, develops topical products for the treatment of chronic skin diseases. *Founded* 2012 Durham, United States **$37M** last round Dec 2014 - 23 [**Biomason** Biomason, Inc.](https://millionrounds.com/company/biomason) Biomason, Inc. *Founded* 2012 Durham, United States **$37M** last round Jan 2025 - 24 [**Validic** Validic is a technology platform that offers digital health and remote care programs for healthcare organizations.](https://millionrounds.com/company/validic) Validic is a technology platform that offers digital health and remote care programs for healthcare organizations. *Founded* 2010 Durham, United States **$30M** last round Jan 2023 - 25 [**410 Medical** 410 Medical is a medical device company dedicated to developing innovative products that enable frontline medical providers to improve care.](https://millionrounds.com/company/410-medical) 410 Medical is a medical device company dedicated to developing innovative products that enable frontline medical providers to improve care. *Founded* 2013 Durham, United States **$29M** last round Jul 2026 - 26 [**Vascular Pharmaceuticals** Vascular Pharmaceuticals engages in the development of therapeutics targeting the treatment of diabetes associated complications.](https://millionrounds.com/company/vascular-pharmaceuticals) Vascular Pharmaceuticals engages in the development of therapeutics targeting the treatment of diabetes associated complications. *Founded* 2005 Durham, United States **$26M** last round Mar 2015 - 27 [**Bantam Pharmaceutical** Bantam Pharmaceutical, also known as Bantam Pharma, is a clinical-stage biopharmaceutical company founded in 2015 and based in Durham, North Carolina.](https://millionrounds.com/company/bantam-pharmaceutical) Bantam Pharmaceutical, also known as Bantam Pharma, is a clinical-stage biopharmaceutical company founded in 2015 and based in Durham, North Carolina. *Founded* 2015 Durham, United States **$25M** last round Sept 2021 - 28 [**Pairwise** Pairwise is an agricultural biotechnology company based in Durham, North Carolina, founded in 2017 by Dr.](https://millionrounds.com/company/pairwise) Pairwise is an agricultural biotechnology company based in Durham, North Carolina, founded in 2017 by Dr. *Founded* 2017 Durham, United States **$25M** last round Mar 2018 - 29 [**Ramona** Ramona develops high-throughput microscopy tools to unlock previously impossible experiments within the modern biology lab.](https://millionrounds.com/company/ramona) Ramona develops high-throughput microscopy tools to unlock previously impossible experiments within the modern biology lab. *Founded* 2018 Durham, United States **$25M** last round Sept 2026 - 30 [**LabConnect** LabConnect is a leading provider of central laboratory services and clinical trial support solutions, established in 2002 and headquartered in Johnson City, Tennessee.](https://millionrounds.com/company/labconnect) LabConnect is a leading provider of central laboratory services and clinical trial support solutions, established in 2002 and headquartered in Johnson City, Tennessee. *Founded* 2002 Durham, United States **$25M** last round Jun 2017 - 31 [**T3D Therapeutics** T3D Therapeutics is a company developing remedial therapeutics for Alzheimer’s disease and other CNS disorders.](https://millionrounds.com/company/t3d-therapeutics) T3D Therapeutics is a company developing remedial therapeutics for Alzheimer’s disease and other CNS disorders. *Founded* 2013 Durham, United States **$24M** last round Sept 2022 - 32 [**Kincell Bio** Kincell Bio is a cell therapy Contract Development and Manufacturing Organization (CDMO) founded in 2023 as a spin-out from Inceptor Bio.](https://millionrounds.com/company/kincell-bio) Kincell Bio is a cell therapy Contract Development and Manufacturing Organization (CDMO) founded in 2023 as a spin-out from Inceptor Bio. *Founded* 2023 Durham, United States **$22M** last round Sept 2026 - 33 [**Keebler Health** Keebler Health is a healthcare technology company based in Durham, North Carolina, founded in 2023.](https://millionrounds.com/company/keebler-health) Keebler Health is a healthcare technology company based in Durham, North Carolina, founded in 2023. *Founded* 2023 Durham, United States **$22M** last round Apr 2026 - 34 [**BIOMILQ** BIOMILQ is a North Carolina-based biotechnology company focused on developing cell-cultured human milk to enhance infant nutrition.](https://millionrounds.com/company/biomilq) BIOMILQ is a North Carolina-based biotechnology company focused on developing cell-cultured human milk to enhance infant nutrition. *Founded* 2019 Durham, United States **$21M** last round Oct 2021 - 35 [**Mendel Biotechnology** Mendel Biotechnology is a plant biotechnology company that develops genetic and chemical solutions for a range of agricultural markets.](https://millionrounds.com/company/mendel-biotechnology) Mendel Biotechnology is a plant biotechnology company that develops genetic and chemical solutions for a range of agricultural markets. *Founded* 1997 Durham, United States **$20M** last round Nov 2011 - 36 [**FoodLogiQ** FoodLogiQ provides a food traceability, food safety, food sustainability, and supply chain transparency software.](https://millionrounds.com/company/foodlogiq) FoodLogiQ provides a food traceability, food safety, food sustainability, and supply chain transparency software. *Founded* 2006 Durham, United States **$20M** last round Mar 2018 - 37 [**Xilis** Xilis is an oncology and precision health company that provides technologies to diagnoses cancer.](https://millionrounds.com/company/xilis) Xilis is an oncology and precision health company that provides technologies to diagnoses cancer. *Founded* 2019 Durham, United States **$19M** last round Apr 2025 - 38 [**Spyryx Biosciences** Spyryx Biosciences develops a next-generation therapeutics for obstructive lung diseases.](https://millionrounds.com/company/spyryx-biosciences) Spyryx Biosciences develops a next-generation therapeutics for obstructive lung diseases. *Founded* 2013 Durham, United States **$18M** last round May 2015 - 39 [**Tavros Therapeutics** Tavros Therapeutics is an emerging biotechnology company that discovers and develops therapies for cancer.](https://millionrounds.com/company/tavros-therapeutics) Tavros Therapeutics is an emerging biotechnology company that discovers and develops therapies for cancer. *Founded* 2019 Durham, United States **$18M** last round Oct 2022 - 40 [**Arpio** Arpio, Inc.](https://millionrounds.com/company/arpio) Arpio, Inc. *Founded* 2018 Durham, United States **$16M** last round Jun 2026 - 41 [**Incyclix Bio** Incyclix Bio, LLC is a biotechnology company based in Research Triangle Park, North Carolina, founded in 2020 by experts in cyclin-dependent kinase (CDK) research.](https://millionrounds.com/company/incyclix-bio) Incyclix Bio, LLC is a biotechnology company based in Research Triangle Park, North Carolina, founded in 2020 by experts in cyclin-dependent kinase (CDK) research. *Founded* 2020 Durham, United States **$16M** last round Apr 2026 - 42 [**Nuvotronics** Nuvotronics designs, develops, and fabricates custom networks of circuits and passive components for complex microwave systems.](https://millionrounds.com/company/nuvotronics) Nuvotronics designs, develops, and fabricates custom networks of circuits and passive components for complex microwave systems. *Founded* 2008 Durham, United States **$15M** last round Jul 2015 - 43 [**Polarean** Polarean is manufacturer and service provider for noble gas polarizer devices and ancillary instruments.](https://millionrounds.com/company/polarean) Polarean is manufacturer and service provider for noble gas polarizer devices and ancillary instruments. *Founded* 2011 Durham, United States **$15M** last round May 2024 - 44 [**Revian** Revian is the manufacturer and supplier of medical-grade LED technology.](https://millionrounds.com/company/revian) Revian is the manufacturer and supplier of medical-grade LED technology. *Founded* 2016 Durham, United States **$13M** last round Nov 2025 - 45 [**BotBuilt** BotBuilt is a construction technology startup based in Durham, North Carolina, founded in 2020.](https://millionrounds.com/company/botbuilt) BotBuilt is a construction technology startup based in Durham, North Carolina, founded in 2020. *Founded* 2020 Durham, United States **$12M** last round Dec 2023 - 46 [**Automated Insights** Automated Insights is the creator of Wordsmith, the world’s first public natural language generation platform.](https://millionrounds.com/company/automated-insights) Automated Insights is the creator of Wordsmith, the world’s first public natural language generation platform. *Founded* 2007 Durham, United States **$12M** last round Jun 2014 - 47 [**Duke Center for Autism and Brain Development** The Duke Center for Autism and Brain Development provides assistance to each person with autism and related developmental disabilities.](https://millionrounds.com/company/duke-center-for-autism-and-brain-development) The Duke Center for Autism and Brain Development provides assistance to each person with autism and related developmental disabilities. *Founded* - Durham, United States **$12M** last round Sept 2022 - 48 [**Keen Decision Systems** Keen Decision Systems is an AI-powered SaaS company founded in 2010, specializing in marketing mix modeling (MMM).](https://millionrounds.com/company/keen-decision-systems) Keen Decision Systems is an AI-powered SaaS company founded in 2010, specializing in marketing mix modeling (MMM). *Founded* 2010 Durham, United States **$11M** last round Jul 2022 - 49 [**The Looma Project** The people & stories behind your products.](https://millionrounds.com/company/the-looma-project) The people & stories behind your products. *Founded* 2015 Durham, United States **$10M** last round Sept 2024 - 50 [**Precision Fermentation** Precision Fermentation offers real-time fermentation monitoring solution for the craft beer industry.](https://millionrounds.com/company/precision-fermentation) Precision Fermentation offers real-time fermentation monitoring solution for the craft beer industry. *Founded* 2017 Durham, United States **$10M** last round Apr 2026 **Total funding** how the list is ranked **15 November 2026** updated nightly **Rounds we track** source: Millionrounds Every startup we hold in Durham, ranked by the total it has raised in rounds we hold. Nobody pays to be on a list. ## Who backed them? Open any company for its rounds and investors, or search the investors who back startups in Durham in the app, with filters, lists and exports. [Find their investors](https://millionrounds.com/login?join=1&next=/app/investors)[All top lists](https://millionrounds.com/top-lists) ## More startup lists [See all](https://millionrounds.com/top-lists?t=All%20startups) [*O* *A* *X* **Startups in the United States** 42,176 companies · $870B](https://millionrounds.com/top-lists/startups-united-states)[*SC* *N* *F* **Startups in the United Kingdom** 8,355 companies · $79B](https://millionrounds.com/top-lists/startups-united-kingdom)[*O* *D* *TM* **Startups in San Francisco** 4,251 companies · $350B](https://millionrounds.com/top-lists/startups-san-francisco)[*W* *K* *P* **Startups in New York** 3,729 companies · $67B](https://millionrounds.com/top-lists/startups-new-york)[*F* *IL* *PD* **Startups in London** 3,521 companies · $51B](https://millionrounds.com/top-lists/startups-london)[*MA* *M* *TE* **Startups in France** 3,025 companies · $32B](https://millionrounds.com/top-lists/startups-france)[*C* *H8* *AP* **Startups in Canada** 2,950 companies · $38B](https://millionrounds.com/top-lists/startups-canada)[*B* *D* *AF* **Startups in China** 2,168 companies · $163B](https://millionrounds.com/top-lists/startups-china) ## More lists for Durham [See all](https://millionrounds.com/top-lists?r=Durham) [*H* *AT* *AT* **Biotech startups in Durham** 41 companies · $1.0B](https://millionrounds.com/top-lists/biotech-startups-durham)[*B* *H* *B* **Healthcare startups in Durham** 24 companies · $985M](https://millionrounds.com/top-lists/healthcare-startups-durham)