# Top 37 Biotech Startups in Waltham by Funding (2026)

> The 37 best-funded biotech startups in Waltham, ranked by total funding raised: $5.6B combined. With founding year, headquarters and each company's rounds.

Source: https://millionrounds.com/top-lists/biotech-startups-waltham (Millionrounds; every figure on the page links to its filing or article)

- 1 [**Oruka Therapeutics** Oruka Therapeutics is advancing innovative biologics to redefine patient care standards in chronic skin diseases.](https://millionrounds.com/company/oruka-therapeutics) Oruka Therapeutics is advancing innovative biologics to redefine patient care standards in chronic skin diseases. *Founded* - Waltham, United States **$880M** last round Apr 2026
- 2 [**Dyne Therapeutics** Dyne Therapeutics is a developer of targeted therapies intended for serious muscle diseases.](https://millionrounds.com/company/dyne-therapeutics) Dyne Therapeutics is a developer of targeted therapies intended for serious muscle diseases. *Founded* 2018 Waltham, United States **$828M** last round Jul 2026
- 3 [**Kailera Therapeutics** Kailera Therapeutics develops next-generation injectable and oral therapies for chronic weight management.](https://millionrounds.com/company/kailera-therapeutics) Kailera Therapeutics develops next-generation injectable and oral therapies for chronic weight management. *Founded* - Waltham, United States **$600M** last round Oct 2025
- 4 [**ElevateBio** ElevateBio is a biotechnology company based in Waltham, Massachusetts, founded in 2017.](https://millionrounds.com/company/elevatebio) ElevateBio is a biotechnology company based in Waltham, Massachusetts, founded in 2017. *Founded* 2017 Waltham, United States **$551M** last round May 2023
- 5 [**Zenas BioPharma** Zenas BioPharma is a biopharmaceutical company that focuses on developing immune-based therapies for patients.](https://millionrounds.com/company/zenas-biopharma) Zenas BioPharma is a biopharmaceutical company that focuses on developing immune-based therapies for patients. *Founded* 2023 Waltham, United States **$420M** last round Mar 2026
- 6 [**Morphic Therapeutic** Morphic Therapeutic is a biotechnology company that develops oral integrin therapies to treat serious chronic diseases.](https://millionrounds.com/company/morphic-therapeutic) Morphic Therapeutic is a biotechnology company that develops oral integrin therapies to treat serious chronic diseases. *Founded* 2015 Waltham, United States **$328M** last round May 2023
- 7 [**Upstream Bio** Upstream Bio focuses on developing an antibody therapy for the treatment of severe asthma.](https://millionrounds.com/company/upstream-bio) Upstream Bio focuses on developing an antibody therapy for the treatment of severe asthma. *Founded* 2021 Waltham, United States **$200M** last round Jun 2023
- 8 [**BostonGene** BostonGene is a biotechnology company based in Waltham, Massachusetts, founded in 2015.](https://millionrounds.com/company/bostongene) BostonGene is a biotechnology company based in Waltham, Massachusetts, founded in 2015. *Founded* 2015 Waltham, United States **$200M** last round Apr 2022
- 9 [**Cogent Biosciences** Cogent Biosciences is a biotechnology company that develops therapies for solid cancer tumors.](https://millionrounds.com/company/cogent-biosciences) Cogent Biosciences is a biotechnology company that develops therapies for solid cancer tumors. *Founded* 2014 Waltham, United States **$200M** last round Nov 2025
- 10 [**Skyhawk Therapeutics** Skyhawk Therapeutics is a clinical-stage biotechnology company located in Waltham, Massachusetts.](https://millionrounds.com/company/skyhawk-therapeutics) Skyhawk Therapeutics is a clinical-stage biotechnology company located in Waltham, Massachusetts. *Founded* 2016 Waltham, United States **$133M** last round Sept 2021
- 11 [**Deciphera Pharmaceuticals** Deciphera Pharmaceuticals focuses on improving kinase inhibitor treatments.](https://millionrounds.com/company/deciphera-pharmaceuticals) Deciphera Pharmaceuticals focuses on improving kinase inhibitor treatments. *Founded* 2003 Waltham, United States **$127M** last round Jun 2017
- 12 [**Invivyd** Invivyd develops antibodies to transcend the limitations of the human immune system and fight against viral infections.](https://millionrounds.com/company/invivyd) Invivyd develops antibodies to transcend the limitations of the human immune system and fight against viral infections. *Founded* 2020 Waltham, United States **$125M** last round Nov 2025
- 13 [**Visterra** Visterra researches on and develops therapeutic and diagnostic products for the treatment of infectious diseases.](https://millionrounds.com/company/visterra) Visterra researches on and develops therapeutic and diagnostic products for the treatment of infectious diseases. *Founded* 2007 Waltham, United States **$120M** last round Oct 2017
- 14 [**Palleon Pharmaceuticals** Palleon Pharmaceuticals is a clinical-stage biotechnology company based in Waltham, Massachusetts.](https://millionrounds.com/company/palleon-pharmaceuticals) Palleon Pharmaceuticals is a clinical-stage biotechnology company based in Waltham, Massachusetts. *Founded* 2016 Waltham, United States **$100M** last round Sept 2020
- 15 [**TScan Therapeutics** TScan Therapeutics is a biopharmaceutical company focused on the development of immunotherapy treatments for cancer.](https://millionrounds.com/company/tscan-therapeutics) TScan Therapeutics is a biopharmaceutical company focused on the development of immunotherapy treatments for cancer. *Founded* 2018 Waltham, United States **$78M** last round Dec 2024
- 16 [**Exosome Diagnostics** Exosome Diagnostics develops and commercializes blood-based cancer molecular diagnostics for patient stratification and disease monitoring.](https://millionrounds.com/company/exosome-diagnostics) Exosome Diagnostics develops and commercializes blood-based cancer molecular diagnostics for patient stratification and disease monitoring. *Founded* 2008 Waltham, United States **$76M** last round Sept 2015
- 17 [**Photys Therapeutics** Photys Therapeutics is a biotechnology and pharmaceutical research company founded in 2021 and based in Waltham, Massachusetts.](https://millionrounds.com/company/photys-therapeutics) Photys Therapeutics is a biotechnology and pharmaceutical research company founded in 2021 and based in Waltham, Massachusetts. *Founded* 2021 Waltham, United States **$75M** last round Sept 2022
- 18 [**Eloxx** Eloxx Pharmaceuticals is a clinical-stage biopharmaceutical company developing novel RNA-modulating drug candidates.](https://millionrounds.com/company/eloxx) Eloxx Pharmaceuticals is a clinical-stage biopharmaceutical company developing novel RNA-modulating drug candidates. *Founded* 2013 Waltham, United States **$66M** last round Jun 2026
- 19 [**Orionis Biosciences** Orionis Biosciences is a clinical-stage life sciences company based in Waltham, Massachusetts, with a research facility in Ghent, Belgium.](https://millionrounds.com/company/orionis-biosciences) Orionis Biosciences is a clinical-stage life sciences company based in Waltham, Massachusetts, with a research facility in Ghent, Belgium. *Founded* 2015 Waltham, United States **$59M** last round Oct 2022
- 20 [**Immunitas Therapeutics** Immunitas Therapeutics is a clinical-stage biopharmaceutical company founded in 2019, focused on discovering and developing novel antibody-based therapeutics fo](https://millionrounds.com/company/immunitas-therapeutics) Immunitas Therapeutics is a clinical-stage biopharmaceutical company founded in 2019, focused on discovering and developing novel antibody-based therapeutics fo *Founded* 2019 Waltham, United States **$58M** last round Aug 2021
- 21 [**Instylla** Instylla is a medical equipment supplier that provides liquid embolics of the next generation for interventional radiology.](https://millionrounds.com/company/instylla) Instylla is a medical equipment supplier that provides liquid embolics of the next generation for interventional radiology. *Founded* 2017 Waltham, United States **$56M** last round Jul 2026
- 22 [**Convergent Dental** Convergent Dental develops a computer-guided, laser-based drilling, and cutting system for dentists.](https://millionrounds.com/company/convergent-dental) Convergent Dental develops a computer-guided, laser-based drilling, and cutting system for dentists. *Founded* 2011 Waltham, United States **$52M** last round Apr 2023
- 23 [**Sojournix** Sojournix is a clinical-stage pharmaceutical company that researches and develops novel therapeutics for the treatment of neuroendocrine disorders.](https://millionrounds.com/company/sojournix) Sojournix is a clinical-stage pharmaceutical company that researches and develops novel therapeutics for the treatment of neuroendocrine disorders. *Founded* 2016 Waltham, United States **$44M** last round Jan 2019
- 24 [**NanoMosaic** NanoMosaic provides solutions for early illness detection, prognostic monitoring, and biomarker identification.](https://millionrounds.com/company/nanomosaic) NanoMosaic provides solutions for early illness detection, prognostic monitoring, and biomarker identification. *Founded* 2018 Waltham, United States **$44M** last round Nov 2025
- 25 [**Affinia Therapeutics** Affinia Therapeutics is a preclinical-stage biotechnology company based in Waltham, Massachusetts, founded in 2019.](https://millionrounds.com/company/affinia-therapeutics) Affinia Therapeutics is a preclinical-stage biotechnology company based in Waltham, Massachusetts, founded in 2019. *Founded* 2019 Waltham, United States **$40M** last round Oct 2025
- 26 [**Pyramid Biosciences** Pyramid Biosciences is a clinical-stage biotechnology company based in New Jersey, founded in 2015.](https://millionrounds.com/company/pyramid-biosciences) Pyramid Biosciences is a clinical-stage biotechnology company based in New Jersey, founded in 2015. *Founded* 2015 Waltham, United States **$34M** last round Oct 2021
- 27 [**Vicarious Surgical** Vicarious Surgical is a robotics company that develops robotic systems that allow surgeons to perform minimally invasive surgery.](https://millionrounds.com/company/vicarious-surgical) Vicarious Surgical is a robotics company that develops robotic systems that allow surgeons to perform minimally invasive surgery. *Founded* 2014 Waltham, United States **$33M** last round Oct 2025
- 28 [**Avilar Therapeutics** Avilar Therapeutics is a biopharmaceutical company based in Waltham, Massachusetts, founded in 2020.](https://millionrounds.com/company/avilar-therapeutics) Avilar Therapeutics is a biopharmaceutical company based in Waltham, Massachusetts, founded in 2020. *Founded* 2020 Waltham, United States **$15M** last round Feb 2023
- 29 [**Fortitude Biomedicines** Fortitude Biomedicines, Inc.](https://millionrounds.com/company/fortitude-biomedicines) Fortitude Biomedicines, Inc. *Founded* 2025 Waltham, United States **$13M** last round Jan 2026
- 30 [**Lucy Therapeutics** Lucy Therapeutics is a private biotechnology company based in Waltham, Massachusetts, founded in 2017.](https://millionrounds.com/company/lucy-therapeutics) Lucy Therapeutics is a private biotechnology company based in Waltham, Massachusetts, founded in 2017. *Founded* 2017 Waltham, United States **$13M** last round May 2024
- 31 [**NKT Therapeutics** NKT Therapeutics is a privately held biotechnology company focused on developing therapeutics to treat cancer and other serious diseases.](https://millionrounds.com/company/nkt-therapeutics) NKT Therapeutics is a privately held biotechnology company focused on developing therapeutics to treat cancer and other serious diseases. *Founded* 2008 Waltham, United States **$12M** last round Aug 2010
- 32 [**ENSEM Therapeutics** Ensem Therapeutics is a biopharmaceutical company based in Waltham, Massachusetts, focused on developing innovative small-molecule precision medicines for oncology.](https://millionrounds.com/company/ensem-therapeutics) Ensem Therapeutics is a biopharmaceutical company based in Waltham, Massachusetts, focused on developing innovative small-molecule precision medicines for oncology. *Founded* 2021 Waltham, United States **$10M** last round Oct 2023
- 33 [**Bonito Biosciences** Bonito Biosciences is a biotechnology research firm specializing in tissue-selective drug delivery for oligonucleotides and macromolecules.](https://millionrounds.com/company/bonito-biosciences) Bonito Biosciences is a biotechnology research firm specializing in tissue-selective drug delivery for oligonucleotides and macromolecules. *Founded* - Waltham, United States **$9.0M** last round May 2024
- 34 [**Minerva Biotechnologies** Minerva Biotechnologies develops cancer immunotherapies and cancer drugs to target 80% of solid tumors and to prevent cancer metastasis.](https://millionrounds.com/company/minerva-biotechnologies) Minerva Biotechnologies develops cancer immunotherapies and cancer drugs to target 80% of solid tumors and to prevent cancer metastasis. *Founded* 1999 Waltham, United States **$8.2M** last round Oct 2014
- 35 [**Amagma Therapeutics** Amagma is a biotechnology company that develops and commercializes antibody therapeutics for the treatment of inflammatory diseases.](https://millionrounds.com/company/amagma-therapeutics) Amagma is a biotechnology company that develops and commercializes antibody therapeutics for the treatment of inflammatory diseases. *Founded* 2019 Waltham, United States **$2.3M** last round Jun 2022
- 36 [**Paragonix Technologies** Paragonix Technologies is a medical device company specialized in organ preservation devices for the improvement of donor organ quality.](https://millionrounds.com/company/paragonix-technologies) Paragonix Technologies is a medical device company specialized in organ preservation devices for the improvement of donor organ quality. *Founded* 2010 Waltham, United States **$1.1M** last round Dec 2013
- 37 [**Ventus Therapeutics** Ventus Therapeutics develops small molecule drugs that target autoimmune diseases, inflammatory diseases, and cancer.](https://millionrounds.com/company/ventus-therapeutics) Ventus Therapeutics develops small molecule drugs that target autoimmune diseases, inflammatory diseases, and cancer. *Founded* 2019 Waltham, United States **$150K** last round Apr 2023

**Total funding** how the list is ranked

**15 November 2026** updated nightly

**Rounds we track** source: Millionrounds

Companies whose funding rounds we classed in this sector, ranked by the total they have raised in rounds we hold. Nobody pays to be on a list.

## Who backed them?

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## More biotech lists

[See all](https://millionrounds.com/top-lists?t=Biotech)

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