# Top 50 Biotech Startups in San Francisco by Funding (2026)

> The 50 best-funded biotech startups in San Francisco, ranked by total funding raised: $12B combined. With founding year, headquarters and each company's rounds.

Source: https://millionrounds.com/top-lists/biotech-startups-san-francisco (Millionrounds; every figure on the page links to its filing or article)

- 1 [**Mirendil** Mirendil is an AI research lab that creates self-accelerating systems that convert computing power into scientific advancements.](https://millionrounds.com/company/mirendil) Mirendil is an AI research lab that creates self-accelerating systems that convert computing power into scientific advancements. *Founded* - San Francisco, United States **$1.4B** last round Nov 2026
- 2 [**Apogee Therapeutics** Apogee Therapeutics is a biotechnology company that offers therapies for immunological and inflammatory disorders.](https://millionrounds.com/company/apogee-therapeutics) Apogee Therapeutics is a biotechnology company that offers therapies for immunological and inflammatory disorders. *Founded* 2022 San Francisco, United States **$1.3B** last round May 2026
- 3 [**Collective Health** Collective Health is an independent third-party administrator and integrated health benefits platform founded in 2013.](https://millionrounds.com/company/collective-health) Collective Health is an independent third-party administrator and integrated health benefits platform founded in 2013. *Founded* 2013 San Francisco, United States **$720M** last round May 2021
- 4 [**Denali Therapeutics** Denali Therapeutics is dedicated to defeating neurodegenerative diseases to deliver safe and effective medicines to patients and families.](https://millionrounds.com/company/denali-therapeutics) Denali Therapeutics is dedicated to defeating neurodegenerative diseases to deliver safe and effective medicines to patients and families. *Founded* 2013 San Francisco, United States **$547M** last round Dec 2025
- 5 [**Chai Discovery** Chai Discovery is an artificial intelligence biotechnology company based in San Francisco, California, founded in March 2024.](https://millionrounds.com/company/chai-discovery) Chai Discovery is an artificial intelligence biotechnology company based in San Francisco, California, founded in March 2024. *Founded* - San Francisco, United States **$530M** last round Jul 2026
- 6 [**Hinge Health** Hinge Health is a digital clinic for joint, and muscle care, pelvic pain, bowel, and bladder control.](https://millionrounds.com/company/hinge-health) Hinge Health is a digital clinic for joint, and muscle care, pelvic pain, bowel, and bladder control. *Founded* 2015 San Francisco, United States **$434M** last round Oct 2021
- 7 [**89Bio** 89bio is a biopharmaceutical company that develops clinical-stage therapies for liver and cardiometabolic diseases.](https://millionrounds.com/company/89bio) 89bio is a biopharmaceutical company that develops clinical-stage therapies for liver and cardiometabolic diseases. *Founded* 2018 San Francisco, United States **$348M** last round Jan 2025
- 8 [**Alumis** Alumis is a precision medicine company focused on the discovery, development and treatment of autoimmune disorders.](https://millionrounds.com/company/alumis) Alumis is a precision medicine company focused on the discovery, development and treatment of autoimmune disorders. *Founded* 2021 San Francisco, United States **$345M** last round Jan 2026
- 9 [**Dice Therapeutics** Dice Therapeutics is a clinical-stage biopharmaceutical company that makes medicines for chronic autoimmune and inflammatory diseases.](https://millionrounds.com/company/dice-therapeutics) Dice Therapeutics is a clinical-stage biopharmaceutical company that makes medicines for chronic autoimmune and inflammatory diseases. *Founded* 2013 San Francisco, United States **$345M** last round Oct 2022
- 10 [**BrainCo** Brain Co.](https://millionrounds.com/company/brainco) Brain Co. *Founded* - San Francisco, United States **$292M** last round Jan 2026
- 11 [**Expedition Therapeutics** Expedition Therapeutics is a biotechnology company based in San Francisco, founded in 2024.](https://millionrounds.com/company/expedition-therapeutics) Expedition Therapeutics is a biotechnology company based in San Francisco, founded in 2024. *Founded* 2024 San Francisco, United States **$280M** last round Aug 2026
- 12 [**Merge Labs** Merge Labs provides a single API to connect software applications with multiple third-party platforms.](https://millionrounds.com/company/merge-labs) Merge Labs provides a single API to connect software applications with multiple third-party platforms. *Founded* 2016 San Francisco, United States **$252M** last round Jan 2026
- 13 [**Nurix Therapeutics** Nurix Therapeutics is a biopharmaceutical company that focuses on the development and discovery of small molecule drugs.](https://millionrounds.com/company/nurix-therapeutics) Nurix Therapeutics is a biopharmaceutical company that focuses on the development and discovery of small molecule drugs. *Founded* 2012 San Francisco, United States **$250M** last round Oct 2025
- 14 [**Alector** Alector is a biopharmaceutical company that develops therapies for the treatment of neurodegeneration diseases.](https://millionrounds.com/company/alector) Alector is a biopharmaceutical company that develops therapies for the treatment of neurodegeneration diseases. *Founded* 2013 San Francisco, United States **$215M** last round Nov 2024
- 15 [**Omada Health** Omada Health is a digital behavioral medicine company that helps members change their mindsets to improve health and build lasting change.](https://millionrounds.com/company/omada-health) Omada Health is a digital behavioral medicine company that helps members change their mindsets to improve health and build lasting change. *Founded* 2011 San Francisco, United States **$200M** last round May 2025
- 16 [**Marea Therapeutics** Marea is a biotechnology firm that uses the advancements in human genetics next-generation medications for cardiometabolic illnesses.](https://millionrounds.com/company/marea-therapeutics) Marea is a biotechnology firm that uses the advancements in human genetics next-generation medications for cardiometabolic illnesses. *Founded* 2022 San Francisco, United States **$190M** last round Jun 2024
- 17 [**Osanni Bio** Osanni Bio is a biotechnology company developing therapies aimed at preventing and reversing blindness caused by retinal diseases.](https://millionrounds.com/company/osanni-bio) Osanni Bio is a biotechnology company developing therapies aimed at preventing and reversing blindness caused by retinal diseases. *Founded* - San Francisco, United States **$190M** last round Jun 2026
- 18 [**Braveheart Bio** Braveheart Bio is a clinical-stage biotechnology company focused on developing precision therapies in the cardiovascular disease space.](https://millionrounds.com/company/braveheart-bio) Braveheart Bio is a clinical-stage biotechnology company focused on developing precision therapies in the cardiovascular disease space. *Founded* - San Francisco, United States **$185M** last round Nov 2025
- 19 [**Benchling** Benchling is a cloud-based platform for biotechnology research and development and the only biology-first platform for scientific data, collaboration, and insights.](https://millionrounds.com/company/benchling) Benchling is a cloud-based platform for biotechnology research and development and the only biology-first platform for scientific data, collaboration, and insights. *Founded* 2012 San Francisco, United States **$162M** last round Nov 2021
- 20 [**Doctor on Demand** Doctor On Demand is a nationwide virtual healthcare provider based in San Francisco, offering 24/7 access to board-certified physicians, licensed psychiatrists,](https://millionrounds.com/company/doctor-on-demand) Doctor On Demand is a nationwide virtual healthcare provider based in San Francisco, offering 24/7 access to board-certified physicians, licensed psychiatrists, *Founded* 2013 San Francisco, United States **$161M** last round Apr 2018
- 21 [**Ginger** Ginger is an on-demand mental health company providing around-the-clock access to emotional support via coaching, therapy, and psychiatry.](https://millionrounds.com/company/ginger) Ginger is an on-demand mental health company providing around-the-clock access to emotional support via coaching, therapy, and psychiatry. *Founded* 2011 San Francisco, United States **$155M** last round Mar 2021
- 22 [**Tenaya Therapeutics** Tenaya Therapeutics is a developer of novel therapies designed to offer treatment for heart disease.](https://millionrounds.com/company/tenaya-therapeutics) Tenaya Therapeutics is a developer of novel therapies designed to offer treatment for heart disease. *Founded* 2016 San Francisco, United States **$152M** last round Dec 2025
- 23 [**Septerna** Septerna is a biotech firm unlocking diverse drug discovery potential in G protein-coupled receptors across various diseases.](https://millionrounds.com/company/septerna) Septerna is a biotech firm unlocking diverse drug discovery potential in G protein-coupled receptors across various diseases. *Founded* 2022 San Francisco, United States **$150M** last round Jul 2023
- 24 [**Vir Biotechnology** Vir Biotechnology is an immunology company that develops products to treat and prevent infectious diseases and other serious conditions.](https://millionrounds.com/company/vir-biotechnology) Vir Biotechnology is an immunology company that develops products to treat and prevent infectious diseases and other serious conditions. *Founded* 2016 San Francisco, United States **$150M** last round Feb 2026
- 25 [**Caresyntax** Caresyntax is a healthcare technology company founded in 2013, specializing in surgical intelligence.](https://millionrounds.com/company/caresyntax) Caresyntax is a healthcare technology company founded in 2013, specializing in surgical intelligence. *Founded* 2013 San Francisco, United States **$144M** last round Aug 2024
- 26 [**Calm** Calm, officially known as Calm.com, Inc., is a prominent American software company based in San Francisco, California.](https://millionrounds.com/company/calm) Calm, officially known as Calm.com, Inc., is a prominent American software company based in San Francisco, California. *Founded* 2012 San Francisco, United States **$143M** last round Jul 2019
- 27 [**NexHealth** NexHealth is a healthcare technology company founded in 2017, based in San Francisco, California.](https://millionrounds.com/company/nexhealth) NexHealth is a healthcare technology company founded in 2017, based in San Francisco, California. *Founded* 2017 San Francisco, United States **$129M** last round Apr 2022
- 28 [**Ouro Medicines** Ouro Medicines is a biotechnology company based in South San Francisco, established in 2025 by Monograph Capital in partnership with GSK.](https://millionrounds.com/company/ouro-medicines) Ouro Medicines is a biotechnology company based in South San Francisco, established in 2025 by Monograph Capital in partnership with GSK. *Founded* 2024 San Francisco, United States **$120M** last round Jan 2025
- 29 [**Cricket Health** Cricket Health is a specialty kidney care provider of integrated nephrology and dialysis care.](https://millionrounds.com/company/cricket-health) Cricket Health is a specialty kidney care provider of integrated nephrology and dialysis care. *Founded* 2015 San Francisco, United States **$110M** last round Aug 2021
- 30 [**T-knife Therapeutics** T-knife Therapeutics is a biopharmaceutical company focused on developing innovative T cell receptor (TCR) engineered T cell therapies for solid tumors.](https://millionrounds.com/company/t-knife-therapeutics) T-knife Therapeutics is a biopharmaceutical company focused on developing innovative T cell receptor (TCR) engineered T cell therapies for solid tumors. *Founded* 2019 San Francisco, United States **$110M** last round Oct 2025
- 31 [**Character Biosciences** Character Biosciences is a precision medicine company founded between 2018 and 2019, focusing on transforming drug development for progressive, polygenic diseas](https://millionrounds.com/company/character-biosciences) Character Biosciences is a precision medicine company founded between 2018 and 2019, focusing on transforming drug development for progressive, polygenic diseas *Founded* 2019 San Francisco, United States **$110M** last round Sept 2025
- 32 [**Presidio Pharmaceuticals** Presidio Pharmaceuticals is a clinical-stage pharmaceutical company focused on the discovery of small-molecule antiviral therapeutics.](https://millionrounds.com/company/presidio-pharmaceuticals) Presidio Pharmaceuticals is a clinical-stage pharmaceutical company focused on the discovery of small-molecule antiviral therapeutics. *Founded* 2006 San Francisco, United States **$109M** last round Jun 2014
- 33 [**Aligos Therapeutics** Aligos Therapeutics is discovering and developing new classes of molecules that interact directly with disease-causing modalities.](https://millionrounds.com/company/aligos-therapeutics) Aligos Therapeutics is discovering and developing new classes of molecules that interact directly with disease-causing modalities. *Founded* 2018 San Francisco, United States **$105M** last round Feb 2025
- 34 [**Vida Health** Vida Health is a virtual care provider specializing in personalized obesity and cardiometabolic care.](https://millionrounds.com/company/vida-health) Vida Health is a virtual care provider specializing in personalized obesity and cardiometabolic care. *Founded* 2014 San Francisco, United States **$102M** last round Nov 2023
- 35 [**Codiak Biosciences** Codiak is a clinical-stage biopharmaceutical company focused on pioneering the development of exosome-based therapeutics.](https://millionrounds.com/company/codiak-biosciences) Codiak is a clinical-stage biopharmaceutical company focused on pioneering the development of exosome-based therapeutics. *Founded* 2015 San Francisco, United States **$100M** last round Sept 2022
- 36 [**Neuron23** Neuron23 is a developer of drugs intended to treat Parkinson's disease and Alzheimer's disease.](https://millionrounds.com/company/neuron23) Neuron23 is a developer of drugs intended to treat Parkinson's disease and Alzheimer's disease. *Founded* 2018 San Francisco, United States **$99M** last round Jun 2026
- 37 [**Atomwise** Atomwise is a technology-enabled pharmaceutical company that focuses on small-molecule drug discovery using deep learning.](https://millionrounds.com/company/atomwise) Atomwise is a technology-enabled pharmaceutical company that focuses on small-molecule drug discovery using deep learning. *Founded* 2012 San Francisco, United States **$97M** last round Jan 2024
- 38 [**Concentric Analgesics** Concentric Analgesics is a biotechnology company that develops non-opioid therapeutics for the management of acute and chronic pain.](https://millionrounds.com/company/concentric-analgesics) Concentric Analgesics is a biotechnology company that develops non-opioid therapeutics for the management of acute and chronic pain. *Founded* 2014 San Francisco, United States **$96M** last round Jan 2022
- 39 [**Incredible Health** Incredible Health is the largest AI-powered healthcare career marketplace in the United States, dedicated to connecting healthcare employers with permanent nurs](https://millionrounds.com/company/incredible-health) Incredible Health is the largest AI-powered healthcare career marketplace in the United States, dedicated to connecting healthcare employers with permanent nurs *Founded* 2017 San Francisco, United States **$95M** last round Aug 2022
- 40 [**Firefly Bio** Firefly Bio specializes in Degrader Antibody Conjugates (DACs) which combine the unique strengths of ADCs with selective protein degraders.](https://millionrounds.com/company/firefly-bio) Firefly Bio specializes in Degrader Antibody Conjugates (DACs) which combine the unique strengths of ADCs with selective protein degraders. *Founded* 2022 San Francisco, United States **$94M** last round Feb 2024
- 41 [**Two Chairs** Two Chairs is a hybrid behavioral health provider founded in 2017 by Alex Katz, headquartered in San Francisco, California.](https://millionrounds.com/company/two-chairs) Two Chairs is a hybrid behavioral health provider founded in 2017 by Alex Katz, headquartered in San Francisco, California. *Founded* 2017 San Francisco, United States **$93M** last round Apr 2024
- 42 [**Augmedix** Augmedix, a Commure company, empowers clinicians to connect with patients by liberating them from administrative burden through the power of ambient AI, data, and trust.](https://millionrounds.com/company/augmedix) Augmedix, a Commure company, empowers clinicians to connect with patients by liberating them from administrative burden through the power of ambient AI, data, and trust. *Founded* 2018 San Francisco, United States **$90M** last round Nov 2023
- 43 [**Frontier Medicines** Frontier Medicines is a biopharmaceutical company that develops a chemoproteomics platform to accelerate the development of medicines.](https://millionrounds.com/company/frontier-medicines) Frontier Medicines is a biopharmaceutical company that develops a chemoproteomics platform to accelerate the development of medicines. *Founded* 2018 San Francisco, United States **$87M** last round Jun 2024
- 44 [**Stride Health** Stride Health is a provider of an insurance recommendation platform designed to offer health insurance services.](https://millionrounds.com/company/stride-health) Stride Health is a provider of an insurance recommendation platform designed to offer health insurance services. *Founded* 2013 San Francisco, United States **$86M** last round Oct 2021
- 45 [**Modern Health** Modern Health is a global mental wellness platform founded in 2017 by Alyson Watson and Erica Johnson, headquartered in San Francisco, California.](https://millionrounds.com/company/modern-health) Modern Health is a global mental wellness platform founded in 2017 by Alyson Watson and Erica Johnson, headquartered in San Francisco, California. *Founded* 2017 San Francisco, United States **$85M** last round Feb 2021
- 46 [**Phil** Medication Access, Simplified.](https://millionrounds.com/company/phil) Medication Access, Simplified. *Founded* 2015 San Francisco, United States **$85M** last round Jul 2025
- 47 [**PellePharm** PellePharm is a biotechnology company dedicated to developing treatments for rare dermatologic diseases, with a particular focus on Gorlin syndrome and basal ce](https://millionrounds.com/company/pellepharm) PellePharm is a biotechnology company dedicated to developing treatments for rare dermatologic diseases, with a particular focus on Gorlin syndrome and basal ce *Founded* 2016 San Francisco, United States **$78M** last round Nov 2018
- 48 [**ClearCare** Clear Care is now WellSky.](https://millionrounds.com/company/clearcare) Clear Care is now WellSky. *Founded* 2010 San Francisco, United States **$76M** last round Aug 2016
- 49 [**Viz.ai** Viz.ai is a healthcare AI company based in San Francisco, founded in 2016 by Dr.](https://millionrounds.com/company/viz-ai) Viz.ai is a healthcare AI company based in San Francisco, founded in 2016 by Dr. *Founded* 2016 San Francisco, United States **$71M** last round Oct 2019
- 50 [**ProLynx** Prolynx is a clinical-stage biotechnology company based in the San Francisco Bay Area, founded in 2009.](https://millionrounds.com/company/prolynx) Prolynx is a clinical-stage biotechnology company based in the San Francisco Bay Area, founded in 2009. *Founded* 2009 San Francisco, United States **$70M** last round Dec 2025

**Total funding** how the list is ranked

**15 November 2026** updated nightly

**Rounds we track** source: Millionrounds

Companies whose funding rounds we classed in this sector, ranked by the total they have raised in rounds we hold. Nobody pays to be on a list.

## Who backed them?

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## More biotech lists

[See all](https://millionrounds.com/top-lists?t=Biotech)

[*IL* *NH* *CS* **Biotech startups in Europe** 1,665 companies · $22B](https://millionrounds.com/top-lists/biotech-startups-europe)[*GV* *IL* *RM* **Biotech startups that raised in 2026** 896 companies · $37B in 2026](https://millionrounds.com/top-lists/biotech-startups-raised-2026)[*IL* *CS* *ON* **Biotech startups in the United Kingdom** 588 companies · $15B](https://millionrounds.com/top-lists/biotech-startups-united-kingdom)[*GV* *RM* *M* **Biotech startups in the United States that raised in 2026** 498 companies · $32B in 2026](https://millionrounds.com/top-lists/biotech-startups-united-states-raised-2026)[*NH* *DT* *E* **Biotech startups founded in 2018** 368 companies · $14B](https://millionrounds.com/top-lists/biotech-startups-founded-2018)[*NR* *LL* *ST* **Biotech startups founded in 2020** 337 companies · $7.0B](https://millionrounds.com/top-lists/biotech-startups-founded-2020)[*E* *ET* *NA* **Biotech startups founded in 2019** 336 companies · $11B](https://millionrounds.com/top-lists/biotech-startups-founded-2019)[*IL* *RB* *VS* **Biotech startups founded in 2021** 275 companies · $12B](https://millionrounds.com/top-lists/biotech-startups-founded-2021)

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