# Top 50 Biotech Startups Founded in 2021 by Funding (2026) > The 50 best-funded biotech startups founded in 2021, ranked by total funding raised: $12B combined. With founding year, headquarters and each company's rounds. Source: https://millionrounds.com/top-lists/biotech-startups-founded-2021 (Millionrounds; every figure on the page links to its filing or article) - 1 [**Isomorphic Labs** Isomorphic Labs is a London-based artificial intelligence company focused on transforming the drug discovery process.](https://millionrounds.com/company/isomorphic-labs) Isomorphic Labs is a London-based artificial intelligence company focused on transforming the drug discovery process. *Founded* 2021 London, United Kingdom **$3.1B** last round May 2026 - 2 [**Retro Biosciences** Retro Biosciences is a biotechnology company based in Redwood City, California, founded in May 2021.](https://millionrounds.com/company/retro-biosciences) Retro Biosciences is a biotechnology company based in Redwood City, California, founded in May 2021. *Founded* 2021 Redwood City, United States **$1.2B** last round May 2026 - 3 [**Varda Space Industries** Varda Space Industries is a private American company based in El Segundo, California, focused on space manufacturing.](https://millionrounds.com/company/varda-space-industries) Varda Space Industries is a private American company based in El Segundo, California, focused on space manufacturing. *Founded* 2021 El Segundo, United States **$438M** last round Oct 2026 - 4 [**Colossal Biosciences** Colossal Biosciences is an American biotechnology and genetic engineering company founded in September 2021, recognized as the world's first dedicated de-extinc](https://millionrounds.com/company/colossal-biosciences) Colossal Biosciences is an American biotechnology and genetic engineering company founded in September 2021, recognized as the world's first dedicated de-extinc *Founded* 2021 Dallas, United States **$380M** last round Feb 2026 - 5 [**Alumis** Alumis is a precision medicine company focused on the discovery, development and treatment of autoimmune disorders.](https://millionrounds.com/company/alumis) Alumis is a precision medicine company focused on the discovery, development and treatment of autoimmune disorders. *Founded* 2021 San Francisco, United States **$345M** last round Jan 2026 - 6 [**ArriVent** ArriVent develops pharmaceutical products to cure presently untreatable cancer.](https://millionrounds.com/company/arrivent) ArriVent develops pharmaceutical products to cure presently untreatable cancer. *Founded* 2021 Pennsylvania Furnace, United States **$325M** last round May 2026 - 7 [**ReNAgade Therapeutics** ReNAgade Therapeutics focuses on the boundless potential of RNA therapeutics to treat disease.](https://millionrounds.com/company/renagade-therapeutics) ReNAgade Therapeutics focuses on the boundless potential of RNA therapeutics to treat disease. *Founded* 2021 Cambridge, United States **$300M** last round May 2023 - 8 [**Terremoto Biosciences** Terremoto Biosciences is a clinical-stage biotechnology company founded in 2021, focused on covalent drug discovery and development.](https://millionrounds.com/company/terremoto-biosciences) Terremoto Biosciences is a clinical-stage biotechnology company founded in 2021, focused on covalent drug discovery and development. *Founded* 2021 South San Francisco, United States **$283M** last round Apr 2026 - 9 [**MoonLake Immunotherapeutics** MoonLake Immunotherapeutics is a clinical-stage biopharmaceuticals company.](https://millionrounds.com/company/moonlake-immunotherapeutics) MoonLake Immunotherapeutics is a clinical-stage biopharmaceuticals company. *Founded* 2021 Zug, Switzerland **$275M** last round Jun 2026 - 10 [**Centessa Pharmaceuticals** Centessa Pharmaceuticals is a pharmaceutical company that focuses on drug development to address significant medical needs.](https://millionrounds.com/company/centessa-pharmaceuticals) Centessa Pharmaceuticals is a pharmaceutical company that focuses on drug development to address significant medical needs. *Founded* 2021 Cambridge, United States **$250M** last round Nov 2025 - 11 [**Odyssey Therapeutics** Odyssey Therapeutics creates precision immunomodulators and oncology medicines for patients with cancer and inflammatory diseases.](https://millionrounds.com/company/odyssey-therapeutics) Odyssey Therapeutics creates precision immunomodulators and oncology medicines for patients with cancer and inflammatory diseases. *Founded* 2021 Boston, United States **$238M** last round May 2026 - 12 [**Matchpoint Therapeutics** Matchpoint Therapeutics is a biotechnology company based in Cambridge, Massachusetts, founded in 2021.](https://millionrounds.com/company/matchpoint-therapeutics) Matchpoint Therapeutics is a biotechnology company based in Cambridge, Massachusetts, founded in 2021. *Founded* 2021 Cambridge, United States **$220M** last round Oct 2026 - 13 [**Tome Biosciences** Tome Biosciences is a biotechnology company based in Watertown, MA, focused on advancing programmable genomic integration (PGI) to develop curative cell and gen](https://millionrounds.com/company/tome-biosciences) Tome Biosciences is a biotechnology company based in Watertown, MA, focused on advancing programmable genomic integration (PGI) to develop curative cell and gen *Founded* 2021 Watertown, United States **$213M** last round Dec 2023 - 14 [**Treeline Biosciences** Treeline Biosciences is a biotech company building transformative precision medicines for patients with cancer and other serious conditions.](https://millionrounds.com/company/treeline-biosciences) Treeline Biosciences is a biotech company building transformative precision medicines for patients with cancer and other serious conditions. *Founded* 2021 Watertown, United States **$200M** last round Sept 2025 - 15 [**Upstream Bio** Upstream Bio focuses on developing an antibody therapy for the treatment of severe asthma.](https://millionrounds.com/company/upstream-bio) Upstream Bio focuses on developing an antibody therapy for the treatment of severe asthma. *Founded* 2021 Waltham, United States **$200M** last round Jun 2023 - 16 [**Aktis Oncology** Aktis Oncology is a biotechnology company discovering and developing a novel class of targeted radiopharmaceuticals.](https://millionrounds.com/company/aktis-oncology) Aktis Oncology is a biotechnology company discovering and developing a novel class of targeted radiopharmaceuticals. *Founded* 2021 Boston, United States **$175M** last round Sept 2024 - 17 [**Mariana Oncology** Mariana Oncology is a biotechnology research industry.](https://millionrounds.com/company/mariana-oncology) Mariana Oncology is a biotechnology research industry. *Founded* 2021 Watertown, United States **$175M** last round Sept 2023 - 18 [**Affini-T Therapeutics** Affini-T Therapeutics is a clinical-stage precision immunotherapy company based in Watertown, Massachusetts.](https://millionrounds.com/company/affini-t-therapeutics) Affini-T Therapeutics is a clinical-stage precision immunotherapy company based in Watertown, Massachusetts. *Founded* 2021 Watertown, United States **$175M** last round Mar 2022 - 19 [**Capstan Therapeutics** Capstan Therapeutics is advancing cell engineering to develop therapeutics for a broad range of diseases.](https://millionrounds.com/company/capstan-therapeutics) Capstan Therapeutics is advancing cell engineering to develop therapeutics for a broad range of diseases. *Founded* 2021 San Diego, United States **$175M** last round Mar 2024 - 20 [**Tourmaline Bio** Tourmaline Bio is a biotechnology company that develops medicines to treat inflammatory and immune diseases in patients.](https://millionrounds.com/company/tourmaline-bio) Tourmaline Bio is a biotechnology company that develops medicines to treat inflammatory and immune diseases in patients. *Founded* 2021 New York, United States **$173M** last round Jan 2024 - 21 [**Caidya** Caidya is a clinical research organization that provides personalized solutions for various therapeutic areas.](https://millionrounds.com/company/caidya) Caidya is a clinical research organization that provides personalized solutions for various therapeutic areas. *Founded* 2021 Raleigh, United States **$165M** last round Jan 2025 - 22 [**Nuvig Therapeutics** Nuvig Therapeutics is advancing innovative and transformational therapies that are designed to induce natural mechanisms to restore immune.](https://millionrounds.com/company/nuvig-therapeutics) Nuvig Therapeutics is advancing innovative and transformational therapies that are designed to induce natural mechanisms to restore immune. *Founded* 2021 Redwood City, United States **$161M** last round Dec 2024 - 23 [**AIRNA** AIRNA is a biotechnology company founded in 2021, focused on discovering and developing RNA editing therapeutics.](https://millionrounds.com/company/airna) AIRNA is a biotechnology company founded in 2021, focused on discovering and developing RNA editing therapeutics. *Founded* 2021 Cambridge, United States **$155M** last round Apr 2025 - 24 [**Bitterroot Bio** Bitterroot Bio, Inc.](https://millionrounds.com/company/bitterroot-bio) Bitterroot Bio, Inc. *Founded* 2021 Palo Alto, United States **$145M** last round Jun 2023 - 25 [**Zura Bio** Zura Bio is a clinical-stage, multi-asset biotechnology company.](https://millionrounds.com/company/zura-bio) Zura Bio is a clinical-stage, multi-asset biotechnology company. *Founded* 2021 Henderson, United States **$144M** last round Feb 2026 - 26 [**AAVantgarde Bio** AAVantgarde Bio is developing gene therapies for inherited retinal disorders.](https://millionrounds.com/company/aavantgarde-bio) AAVantgarde Bio is developing gene therapies for inherited retinal disorders. *Founded* 2021 Milano, Italy **$141M** last round Nov 2025 - 27 [**Accera** Accera is a Danish construction company based in Brøndby, founded in 2021.](https://millionrounds.com/company/accera) Accera is a Danish construction company based in Brøndby, founded in 2021. *Founded* 2021 Brondbyvester, United States **$139M** last round Oct 2013 - 28 [**Chroma Medicine** Chroma Medicine, founded in 2021 and based in Boston/Cambridge, Massachusetts, is a biotechnology company focused on developing epigenetic medicines for genetic](https://millionrounds.com/company/chroma-medicine) Chroma Medicine, founded in 2021 and based in Boston/Cambridge, Massachusetts, is a biotechnology company focused on developing epigenetic medicines for genetic *Founded* 2021 Boston, United States **$135M** last round Feb 2023 - 29 [**ARTBIO** ARTBIO is a clinical-stage biotechnology company founded in 2021, focused on developing alpha radioligand therapies for targeted cancer treatment.](https://millionrounds.com/company/artbio) ARTBIO is a clinical-stage biotechnology company founded in 2021, focused on developing alpha radioligand therapies for targeted cancer treatment. *Founded* 2021 Cambridge, United States **$132M** last round Jul 2025 - 30 [**SonoThera** SonoThera is a biotechnology company based in South San Francisco that focuses on developing ultrasound-guided, nonviral gene therapies.](https://millionrounds.com/company/sonothera) SonoThera is a biotechnology company based in South San Francisco that focuses on developing ultrasound-guided, nonviral gene therapies. *Founded* 2021 South San Francisco, United States **$125M** last round Jun 2026 - 31 [**2seventy bio** 2seventy bio is an immuno-oncology cell therapy company that discovers and develops cancer therapies.](https://millionrounds.com/company/2seventy-bio) 2seventy bio is an immuno-oncology cell therapy company that discovers and develops cancer therapies. *Founded* 2021 Cambridge, United States **$125M** last round Feb 2023 - 32 [**Bonum Therapeutics** Bonum Therapeutics creates a technology platform to treat a wide range of diseases.](https://millionrounds.com/company/bonum-therapeutics) Bonum Therapeutics creates a technology platform to treat a wide range of diseases. *Founded* 2021 Seattle, United States **$120M** last round Apr 2026 - 33 [**Synnovation Therapeutics** Synnovation Therapeutics is a clinical-stage biotechnology company based in Wilmington, Delaware, founded in 2021.](https://millionrounds.com/company/synnovation-therapeutics) Synnovation Therapeutics is a clinical-stage biotechnology company based in Wilmington, Delaware, founded in 2021. *Founded* 2021 Wilmington, United States **$102M** last round Dec 2023 - 34 [**Amber Therapeutics** Amber Therapeutics is a clinical-stage medical technology company based in London, founded in 2021 as a spinout from the University of Oxford.](https://millionrounds.com/company/amber-therapeutics) Amber Therapeutics is a clinical-stage medical technology company based in London, founded in 2021 as a spinout from the University of Oxford. *Founded* 2021 London, United Kingdom **$102M** last round Mar 2026 - 35 [**Context Therapeutics** Context Therapeutics is a clinical-stage biopharmaceutical company.](https://millionrounds.com/company/context-therapeutics) Context Therapeutics is a clinical-stage biopharmaceutical company. *Founded* 2021 Philadelphia, United States **$100M** last round May 2024 - 36 [**OnCusp Therapeutics** OnCusp Therapeutics, Inc.](https://millionrounds.com/company/oncusp-therapeutics) OnCusp Therapeutics, Inc. *Founded* 2021 New York, United States **$100M** last round Jan 2024 - 37 [**Paratus Sciences** Paratus Sciences is a biotechnology startup founded in 2021, based in New York, NY, with a subsidiary in Singapore.](https://millionrounds.com/company/paratus-sciences) Paratus Sciences is a biotechnology startup founded in 2021, based in New York, NY, with a subsidiary in Singapore. *Founded* 2021 Boston, United States **$100M** last round Feb 2023 - 38 [**Inceptive** Inceptive is a biotechnology and artificial intelligence company founded in 2021 and based in Palo Alto, California, with additional offices in Berlin and Zurich.](https://millionrounds.com/company/inceptive) Inceptive is a biotechnology and artificial intelligence company founded in 2021 and based in Palo Alto, California, with additional offices in Berlin and Zurich. *Founded* 2021 Palo Alto, United States **$100M** last round Sept 2023 - 39 [**Alethio Therapeutics** Alethio Therapeutics is a preclinical-stage biotechnology company based in Abingdon Science Park near Oxford, UK.](https://millionrounds.com/company/alethio-therapeutics) Alethio Therapeutics is a preclinical-stage biotechnology company based in Abingdon Science Park near Oxford, UK. *Founded* 2021 Abingdon, United Kingdom **$98M** last round Nov 2026 - 40 [**Proxima** Proxima provides strategic principal investments, governance advisory, and structured alternative solutions.](https://millionrounds.com/company/proxima) Proxima provides strategic principal investments, governance advisory, and structured alternative solutions. *Founded* 2021 United States **$94M** last round Jan 2026 - 41 [**Nested Therapeutics** Nested Therapeutics is a biotechnology company based in Cambridge, Massachusetts, founded in 2021.](https://millionrounds.com/company/nested-therapeutics) Nested Therapeutics is a biotechnology company based in Cambridge, Massachusetts, founded in 2021. *Founded* 2021 Cambridge, United States **$90M** last round Oct 2022 - 42 [**Life Biosciences** Integrated preclinical CRO services provider](https://millionrounds.com/company/life-biosciences) Integrated preclinical CRO services provider *Founded* 2021 United States **$80M** last round Apr 2026 - 43 [**Atavistik Bio** Atavistik Bio is a biotechnology company based in Cambridge, Massachusetts, founded in 2021.](https://millionrounds.com/company/atavistik-bio) Atavistik Bio is a biotechnology company based in Cambridge, Massachusetts, founded in 2021. *Founded* 2021 Cambridge, United States **$80M** last round Mar 2026 - 44 [**Lindus Health** Lindus Health is a next-gen CRO running clinical trials for the health and biotech sectors.](https://millionrounds.com/company/lindus-health) Lindus Health is a next-gen CRO running clinical trials for the health and biotech sectors. *Founded* 2021 Boston, United Kingdom **$77M** last round Jan 2025 - 45 [**Photys Therapeutics** Photys Therapeutics is a biotechnology and pharmaceutical research company founded in 2021 and based in Waltham, Massachusetts.](https://millionrounds.com/company/photys-therapeutics) Photys Therapeutics is a biotechnology and pharmaceutical research company founded in 2021 and based in Waltham, Massachusetts. *Founded* 2021 Waltham, United States **$75M** last round Sept 2022 - 46 [**Ablaze Pharmaceuticals** Ablaze Pharmaceuticals is a clinical-stage biopharmaceutical company based in Shanghai, China, with an office in San Diego, California.](https://millionrounds.com/company/ablaze-pharmaceuticals) Ablaze Pharmaceuticals is a clinical-stage biopharmaceutical company based in Shanghai, China, with an office in San Diego, California. *Founded* 2021 China **$75M** last round Nov 2021 - 47 [**Constructive Bio** Constructive Bio is a biotechnology company based in Cambridge, UK, founded in 2021 as a spin-out from Professor Jason Chin’s laboratory.](https://millionrounds.com/company/constructive-bio) Constructive Bio is a biotechnology company based in Cambridge, UK, founded in 2021 as a spin-out from Professor Jason Chin’s laboratory. *Founded* 2021 Whittlesford, United Kingdom **$73M** last round Apr 2025 - 48 [**Cradle** Cradle Bio B.V.](https://millionrounds.com/company/cradle) Cradle Bio B.V. *Founded* 2021 Amsterdam, Netherlands **$73M** last round Nov 2024 - 49 [**PandMe** PandMe is a DNA testing technology company that enables its users to access their ancestry, genealogy, and inherited traits.](https://millionrounds.com/company/pandme) PandMe is a DNA testing technology company that enables its users to access their ancestry, genealogy, and inherited traits. *Founded* 2021 London, United Kingdom **$73M** last round May 2021 - 50 [**Congruence Therapeutics** Congruence Therapeutics is a Montreal-based biotechnology company founded in 2021 by Clarissa Desjardins, PhD, and Michael Rock Goldsmith.](https://millionrounds.com/company/congruence-therapeutics) Congruence Therapeutics is a Montreal-based biotechnology company founded in 2021 by Clarissa Desjardins, PhD, and Michael Rock Goldsmith. *Founded* 2021 Montreal, Canada **$72M** last round Mar 2026 **Total funding** how the list is ranked **15 November 2026** updated nightly **Rounds we track** source: Millionrounds Companies founded in 2021 whose funding rounds we classed in this sector, ranked by the total they have raised in rounds we hold. Nobody pays to be on a list. ## Who backed them? Open any company for its rounds and investors, or search the investors who back biotech startups founded in 2021 in the app, with filters, lists and exports. [Find their investors](https://millionrounds.com/login?join=1&next=/app/investors)[All top lists](https://millionrounds.com/top-lists) ## More biotech lists [See all](https://millionrounds.com/top-lists?t=Biotech) [*IL* *NH* *CS* **Biotech startups in Europe** 1,665 companies · $22B](https://millionrounds.com/top-lists/biotech-startups-europe)[*GV* *IL* *RM* **Biotech startups that raised in 2026** 896 companies · $37B in 2026](https://millionrounds.com/top-lists/biotech-startups-raised-2026)[*IL* *CS* *ON* **Biotech startups in the United Kingdom** 588 companies · $15B](https://millionrounds.com/top-lists/biotech-startups-united-kingdom)[*GV* *RM* *M* **Biotech startups in the United States that raised in 2026** 498 companies · $32B in 2026](https://millionrounds.com/top-lists/biotech-startups-united-states-raised-2026)[*NH* *DT* *E* **Biotech startups founded in 2018** 368 companies · $14B](https://millionrounds.com/top-lists/biotech-startups-founded-2018)[*NR* *LL* *ST* **Biotech startups founded in 2020** 337 companies · $7.0B](https://millionrounds.com/top-lists/biotech-startups-founded-2020)[*E* *ET* *NA* **Biotech startups founded in 2019** 336 companies · $11B](https://millionrounds.com/top-lists/biotech-startups-founded-2019)[*W* *C* *Y* **Biotech startups in China** 264 companies · $10B](https://millionrounds.com/top-lists/biotech-startups-china) ## More lists worldwide [See all](https://millionrounds.com/top-lists?r=Global) [*GV* *V* *RP* **Health startups worldwide** 12,811 companies · $81B](https://millionrounds.com/top-lists/health-startups)[*O* *A* *X* **AI startups worldwide** 10,238 companies · $830B](https://millionrounds.com/top-lists/ai-startups)[*GV* *V* *RP* **Biotech startups worldwide** 7,127 companies · $70B](https://millionrounds.com/top-lists/biotech-startups)[*D* *B* *FT* **Big data startups worldwide** 3,812 companies · $220B](https://millionrounds.com/top-lists/big-data-startups)[*AF* *R* *S* **Fintech startups worldwide** 3,200 companies · $94B](https://millionrounds.com/top-lists/fintech-startups)[*O* *A* *B* **AI startups that raised in 2026** 2,922 companies · $540B in 2026](https://millionrounds.com/top-lists/ai-startups-raised-2026)[*FT* *CE* *P* **Energy providers startups worldwide** 2,808 companies · $152B](https://millionrounds.com/top-lists/energy-providers-startups)[*A* *P* *O* **Marketing tech startups worldwide** 2,728 companies · $28B](https://millionrounds.com/top-lists/marketing-tech-startups)