# Top 18 AI Startups in Portland by Funding (2026)

> The 18 best-funded AI startups in Portland, ranked by total funding raised: $521M combined. With founding year, headquarters and each company's rounds.

Source: https://millionrounds.com/top-lists/ai-startups-portland (Millionrounds; every figure on the page links to its filing or article)

- 1 [**Panthalassa** Panthalassa is a public-benefit corporation based in Portland, Oregon, founded in 2016.](https://millionrounds.com/company/panthalassa) Panthalassa is a public-benefit corporation based in Portland, Oregon, founded in 2016. *Founded* 2021 Portland, United States **$365M** last round Aug 2026
- 2 [**ConductorOne** ConductorOne integrates permission management for the web and modern infrastructure.](https://millionrounds.com/company/conductorone) ConductorOne integrates permission management for the web and modern infrastructure. *Founded* 2020 Portland, United States **$79M** last round Oct 2025
- 3 [**Oath Surgical** Oath Surgical is a health technology startup founded in 2024 by Dr.](https://millionrounds.com/company/oath-surgical) Oath Surgical is a health technology startup founded in 2024 by Dr. *Founded* 2024 Portland, United States **$24M** last round Oct 2025
- 4 [**Little Bird** Little Bird analyzes social data to deliver insights for smarter enterprise marketing.](https://millionrounds.com/company/littlebird) Little Bird analyzes social data to deliver insights for smarter enterprise marketing. *Founded* 2011 Portland, United States **$15M** last round Mar 2026
- 5 [**Caravel Bio** Caravel Bio is a biotechnology and synthetic biology company based in Portland, Oregon, founded in 2022.](https://millionrounds.com/company/caravel-bio) Caravel Bio is a biotechnology and synthetic biology company based in Portland, Oregon, founded in 2022. *Founded* 2022 Portland, United States **$9.0M** last round Oct 2026
- 6 [**Amboss Technologies** Amboss Technologies is a payments infrastructure company that focuses on providing businesses with instant payment solutions using stablecoins and Bitcoin.](https://millionrounds.com/company/amboss-technologies) Amboss Technologies is a payments infrastructure company that focuses on providing businesses with instant payment solutions using stablecoins and Bitcoin. *Founded* 2021 Portland, United States **$4.1M** last round Jun 2026
- 7 [**Haystack Robotics** At Haystack Robotics, our global team has united around one core purpose – to develop technologies that provide a cleaner, safer and happier world.](https://millionrounds.com/company/haystack-robotics) At Haystack Robotics, our global team has united around one core purpose – to develop technologies that provide a cleaner, safer and happier world. *Founded* 2021 Portland, United States **$4.0M** last round Sept 2026
- 8 [**Reclaim.ai** A smart friend for your calendar that automatically makes time for the things you want to get done.](https://millionrounds.com/company/reclaim-ai) A smart friend for your calendar that automatically makes time for the things you want to get done. *Founded* 2019 Portland, United States **$3.8M** last round Jun 2023
- 9 [**Sightglass** Sightglass is an AI-powered investor relations platform serving both investment managers and capital allocators.](https://millionrounds.com/company/sightglass) Sightglass is an AI-powered investor relations platform serving both investment managers and capital allocators. *Founded* - Portland, United States **$3.0M** last round Dec 2024
- 10 [**Shelpful** Shelpful, Inc.](https://millionrounds.com/company/shelpful) Shelpful, Inc. *Founded* 2021 Portland, United States **$3.0M** last round Dec 2023
- 11 [**Sixty AI** Sixty AI is an AI-powered Personal Relationship Management (PRM) platform founded in 2022 and based in Portland, Oregon.](https://millionrounds.com/company/sixty-ai) Sixty AI is an AI-powered Personal Relationship Management (PRM) platform founded in 2022 and based in Portland, Oregon. *Founded* 2020 Portland, United States **$3.0M** last round Jun 2023
- 12 [**Antfly** Smart agents need needles, not haystacks.](https://millionrounds.com/company/antfly) Smart agents need needles, not haystacks. *Founded* - Portland, United States **$2.0M** last round Sept 2026
- 13 [**Regulate** Regulate is an AI-driven SaaS company for market prediction, product validation, rapid formulation, and real-time regulatory compliance.](https://millionrounds.com/company/regulate) Regulate is an AI-driven SaaS company for market prediction, product validation, rapid formulation, and real-time regulatory compliance. *Founded* 2022 Portland, United States **$1.9M** last round May 2026
- 14 [**CleanHaus** CleanHaus is an AI-powered operations platform designed for short-term rental hosts and cleaners to automate scheduling and payments.](https://millionrounds.com/company/cleanhaus) CleanHaus is an AI-powered operations platform designed for short-term rental hosts and cleaners to automate scheduling and payments. *Founded* - Portland, United States **$1.8M** last round May 2026
- 15 [**Health Technology Innovations** Health Technology Innovations accelerates biomedical imaging with machine learning.](https://millionrounds.com/company/health-technology-innovations) Health Technology Innovations accelerates biomedical imaging with machine learning. *Founded* 2017 Portland, United States **$1.0M** last round Jan 2022
- 16 [**Customer.io** Customer.io is a customer engagement platform founded in 2012 and headquartered in Portland, Oregon.](https://millionrounds.com/company/customer-io) Customer.io is a customer engagement platform founded in 2012 and headquartered in Portland, Oregon. *Founded* 2012 Portland, United States **$400K** last round Mar 2022
- 17 [**Rewire AI** Rewire AI is a private company founded in 2019 by Dr.](https://millionrounds.com/company/rewire-ai) Rewire AI is a private company founded in 2019 by Dr. *Founded* 2019 Portland, United States **$276K** last round Aug 2023
- 18 [**Humans Softtech** Humans Softtech is an AI-driven partnership firm focused on creative digital transformation.](https://millionrounds.com/company/humans-softtech) Humans Softtech is an AI-driven partnership firm focused on creative digital transformation. *Founded* 2022 Portland, United States **$250K** last round Sept 2023

**Total funding** how the list is ranked

**15 November 2026** updated nightly

**Rounds we track** source: Millionrounds

Companies whose funding rounds we classed in this sector, ranked by the total they have raised in rounds we hold. Nobody pays to be on a list.

## Who backed them?

Open any company for its rounds and investors, or search the investors who back AI startups in Portland in the app, with filters, lists and exports.

[Find their investors](https://millionrounds.com/login?join=1&next=/app/investors)[All top lists](https://millionrounds.com/top-lists)

## More ai lists

[See all](https://millionrounds.com/top-lists?t=AI)

[*O* *A* *X* **AI startups in the United States** 5,656 companies · $718B](https://millionrounds.com/top-lists/ai-startups-united-states)[*O* *A* *B* **AI startups that raised in 2026** 2,922 companies · $540B in 2026](https://millionrounds.com/top-lists/ai-startups-raised-2026)[*MA* *N* *NG* **AI startups in Europe** 2,502 companies · $66B](https://millionrounds.com/top-lists/ai-startups-europe)[*O* *A* *W* **AI startups in the United States that raised in 2026** 1,648 companies · $431B in 2026](https://millionrounds.com/top-lists/ai-startups-united-states-raised-2026)[*O* *D* *TM* **AI startups in San Francisco** 1,276 companies · $321B](https://millionrounds.com/top-lists/ai-startups-san-francisco)[*MA* *MA* *M* **AI startups founded in 2023** 956 companies · $47B](https://millionrounds.com/top-lists/ai-startups-founded-2023)[*H* *IL* *SB* **AI startups founded in 2021** 757 companies · $23B](https://millionrounds.com/top-lists/ai-startups-founded-2021)[*H* *F* *S* **AI startups founded in 2020** 656 companies · $14B](https://millionrounds.com/top-lists/ai-startups-founded-2020)

## More lists for Portland

[See all](https://millionrounds.com/top-lists?r=Portland)

[*V* *S* *P* **Startups in Portland** 213 companies · $3.3B](https://millionrounds.com/top-lists/startups-portland)[*C* *B* *M* **IT Services startups in Portland** 22 companies · $130M](https://millionrounds.com/top-lists/it-services-startups-portland)[*VF* *V* *BC* **Biotech startups in Portland** 16 companies · $376M](https://millionrounds.com/top-lists/biotech-startups-portland)[*VF* *V* *BC* **Healthcare startups in Portland** 14 companies · $403M](https://millionrounds.com/top-lists/healthcare-startups-portland)[*AS* *C* *C* **Software startups in Portland** 13 companies · $286M](https://millionrounds.com/top-lists/software-startups-portland)[*P* *H* *H* **Big Data & Analytics startups in Portland** 12 companies · $480M](https://millionrounds.com/top-lists/big-data-startups-portland)[*NL* *NS* *CB* **Food & Beverage startups in Portland** 11 companies · $63M](https://millionrounds.com/top-lists/food-beverage-startups-portland)[*TV* *J* *C* **Internet startups in Portland** 11 companies · $176M](https://millionrounds.com/top-lists/internet-startups-portland)