# RiverVest: portfolio, investments and team

> RiverVest is a vc firm based in United States. 39 investments on record, latest Jun 2021. Portfolio, stages, co-investors and team.

Source: https://millionrounds.com/fund/rivervest-venture-partners (Millionrounds; every figure on the page links to its filing or article)

United States · [Investor](https://millionrounds.com/investors)

# RiverVest

Last cheque observed Jun 2021. Silence since then is not evidence of inactivity: our sources miss unannounced rounds.

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Quiet New fund $275M, Mar 2021 VC firm

Seed Series A Series B Life Sciences Biotechnology Therapeutics

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Cheques on record

**0%** of best year **0** **cheques in 12 months**, 39 on record

Since the last cheque **1979** days **00** hrs **00** min **00** sec

Median round **$50M** Cheque size, as they say **$100K – $10M** Rounds led **1 of 39** Sole investor **3 rounds** Exits **8 from the portfolio** Mostly in **United States, 100%**

Pitch RiverVest

## RiverVest highlights

- 01 39 rounds on record
- 02 Mostly Series A and Series B: 51% of its rounds
- 03 Sole investor in 3 rounds, median $18M
- 04 8 exits from the portfolio

## What they do

> RiverVest is a leading venture capital firm building life science companies From their own website

- **Type:** VC firm (from a list, unverified)
- **Cheque size:** $100K – $10M as they say
- **Stages:** Seed Series A Series B Growth
- **Sectors:** Life Sciences Biotechnology Therapeutics
- **Based in:** Saint Louis, United States
- **Cold pitches:** Not stated

## The record

Every round we can evidence, newest first **39 appearances**

- **2021** 1 round
- **Jun** **[Standard Bariatrics](https://millionrounds.com/company/standard-bariatrics)** Series B · US · Hatteras Venture Partners **$35M** With 5 others
- **2019** 4 rounds
- **Jun** **[Intervene](https://millionrounds.com/company/intervene)** Series B · US · FinSMEs **$15M** With 3 others
- **May** **[Reneo Pharmaceuticals](https://millionrounds.com/company/reneo-pharmaceuticals)** Series A · US · FinSMEs **$50M** With 3 others
- **Apr** **[Scout Bio](https://millionrounds.com/company/scout-bio)** Series B · US · FinSMEs **$20M** *Led*
- **Mar** **[Arch Oncology](https://millionrounds.com/company/arch-oncology)** Series B · US · Businesswire **$50M** With 3 others
- **2017** 2 rounds
- **Aug** **[Amplyx](https://millionrounds.com/company/amplyx)** Series C · US · FinSMEs **$67M** With 6 others
- **May** **[Genoa Pharmaceuticals](https://millionrounds.com/company/genoa-pharmaceuticals)** Series A · US · Businesswire **$62M** With 4 others
- **2016** 1 round
- **Aug** **[Tioma](https://millionrounds.com/company/tioma)** Series A · US · FinSMEs **$86M** With 2 others
- **2015** 1 round
- **Nov** **[Amplyx Pharmaceuticals](https://millionrounds.com/company/amplyx-pharmaceuticals)** Series B · US **$41M** With 2 others
- **2014** 7 rounds
- **Sept** **[Allakos](https://millionrounds.com/company/allakos)** Series A · US **$10M** With 3 others
- **Sept** **[Tryton Medical](https://millionrounds.com/company/tryton-medical)** Venture · US **$20M** With 2 others
- **Aug** **[Allakos](https://millionrounds.com/company/allakos)** Series A · US **$25M** With 3 others
- **Apr** **[Otonomy](https://millionrounds.com/company/otonomy)** Series D · US **$49M** With 11 others
- **Mar** **[SMART WIRES](https://millionrounds.com/company/smart-wires)** Series B · US **$18M** Sole investor
- **Mar** **[Lumena Pharmaceuticals](https://millionrounds.com/company/lumena-pharmaceuticals)** Series B · US **$45M** With 6 others
- **Mar** **[ZS Pharma](https://millionrounds.com/company/zs-pharma)** Series D · US **$55M** With 8 others
- **2013** 4 rounds
- **Oct** **[Securus Medical Group](https://millionrounds.com/company/securus-medical-group)** Series B · US · finsmes.com **$6.5M** With 1 other
- **Sept** **[Otonomy](https://millionrounds.com/company/otonomy)** Series C · US · finsmes.com **$46M** With 7 others
- **May** **[Lumena Pharmaceuticals](https://millionrounds.com/company/lumena-pharmaceuticals)** Series A · US · reuters.com **$23M** With 2 others
- **Jan** **[Tryton Medical](https://millionrounds.com/company/tryton-medical)** Venture · US · pehub.com **$24M** With 2 others
- **2012** 3 rounds
- **Dec** **[Allakos](https://millionrounds.com/company/allakos)** Venture · US · sec.gov **$10.0M** With 4 others
- **Oct** **[ZS Pharma](https://millionrounds.com/company/zs-pharma)** Series C · US · bizjournals.com **$46M** With 5 others
- **Oct** **[SMART WIRES](https://millionrounds.com/company/smart-wires)** Series A · US **$3.0M** Sole investor
- **2011** 1 round
- **Aug** **[Securus Medical Group](https://millionrounds.com/company/securus-medical-group)** Series A · US · finsmes.com **$750K** With 1 other
- **2010** 6 rounds
- **Oct** **[IDEV Technologies](https://millionrounds.com/company/idev-technologies)** Series D · US · finsmes.com **$46M** With 4 others
- **Sept** **[Tryton Medical](https://millionrounds.com/company/tryton-medical)** Series D · US · finsmes.com **$20M** With 3 others
- **Sept** **[Accumetrics](https://millionrounds.com/company/accumetrics)** Venture · US · finsmes.com **$7.0M** With 5 others
- **Aug** **[Otonomy](https://millionrounds.com/company/otonomy)** Series B · US · otonomy.com **$39M** With 3 others
- **Jan** **[Accumetrics](https://millionrounds.com/company/accumetrics)** Series E · US · onbiovc.com **$17M** With 5 others
- **Jan** **[Salient Surgical Technologies](https://millionrounds.com/company/salient-surgical-technologies)** Venture · US · masshightech.com **$15M** With 2 others
- **2008** 1 round
- **Feb** **[Accumetrics](https://millionrounds.com/company/accumetrics)** Series D · US · prnewswire.com **$29M** With 7 others
- **2007** 3 rounds
- **Nov** **[Excaliard Pharmaceuticals](https://millionrounds.com/company/excaliard-pharmaceuticals)** Series A · US · excaliard.com **$16M** With 2 others
- **Jun** **[TissueLink Medical,](https://millionrounds.com/company/tissuelink-medical)** Series E · US **$20M** Sole investor
- **Jan** **[Calypso Medical](https://millionrounds.com/company/calypso-medical)** Series D · US **$42M** With 7 others
- **2006** 1 round
- **May** **[MacroGenics](https://millionrounds.com/company/macrogenics)** Series C · US · macrogenics.com **$45M** With 10 others
- **2004** 2 rounds
- **Sept** **[Velocimed](https://millionrounds.com/company/velocimed)** Series B · US **$17M** With 3 others
- **Jan** **[Auxeris Therapeutics](https://millionrounds.com/company/auxeris-therapeutics)** Series A · US **$1.6M** With 1 other
- **2003** 2 rounds
- **Oct** **[Salient Surgical Technologies](https://millionrounds.com/company/salient-surgical-technologies)** Series D · US **$30M** With 10 others
- **Jul** **[Velocimed](https://millionrounds.com/company/velocimed)** Series C · US **$18M** With 2 others

An announcement gives the size of the round, not the size of this investor's cheque: the only rounds that imply a cheque are those where they were the sole named investor.

## The team

Named by the firm itself, on a filing, its Form ADV or its company registration **7 named**

AW **Anthony W. Arnerich** Member of 3x5 Partners Managers II, LLC. i Filing they signed

JW **Jay William Schmelter** Manager of the general partner of the General Partner. i Filing they signed

JP **John Patrick Mckearn** Manager of the general partner of the General Partner. i Filing they signed

KP **Karen P. Spilizewski** Officer of the General Partner. i Filing they signed

NA **Niall Anthony O'Donnell** Manager of the general partner of the General Partner. i Filing they signed

NW **Nicholas W. Walrod** Member of 3x5 Partners Managers II, LLC. i Filing they signed

TC **Thomas Clifford Melzer** Manager of the General Partner of the Sole Member. i Filing they signed

We also hold **27** people at this firm from the lists this database was built from: a weaker source than the filings, since a list does not say when a title ended. Login to see them.

## What the register says

From the firm's own filings with the SEC, which it must file accurately by law

**$433M** gross assets of its funds Oct 2026

**Exempt** reporting adviser venture or small private funds

- **Legal name:** Rivervest Venture Management LLC
- **SEC number:** CRD 160239

## What they claim to have backed

From their own portfolio page (on their website)

**1** of 4 we have independently watched raise

[Behance](https://millionrounds.com/company/behance) RiverVest Fund IV Statcounter Transparency-in-coverage

Weaker than a round we watched, stronger than a list somebody sold us. A firm is far less willing to put a company on its own site that it never funded.

## Exits from the portfolio

Companies it backed that were later bought or listed **8 in all**

**[ZS Pharma](https://millionrounds.com/company/zs-pharma)** Bought by [AstraZeneca](https://millionrounds.com/fund/astrazeneca) **$2.7B** Nov 2015

**[Lumena Pharmaceuticals](https://millionrounds.com/company/lumena-pharmaceuticals)** Bought by [Shire](https://millionrounds.com/fund/shire) **$260M** May 2014

**[Accumetrics](https://millionrounds.com/company/accumetrics)** Bought by [ITC](https://millionrounds.com/fund/itc) **Undisclosed** Aug 2013

**[IDEV Technologies](https://millionrounds.com/company/idev-technologies)** Bought by [Abbott Labs](https://millionrounds.com/fund/abbott-labs) **$310M** Jul 2013

**[Excaliard Pharmaceuticals](https://millionrounds.com/company/excaliard-pharmaceuticals)** Bought by Excaliard Pharmaceuticals **Undisclosed** Nov 2011

**[Calypso Medical](https://millionrounds.com/company/calypso-medical)** Bought by Varian Medical Systems **Undisclosed** Sept 2011

**[Salient Surgical Technologies](https://millionrounds.com/company/salient-surgical-technologies)** Bought by [Medtronic](https://millionrounds.com/fund/medtronic) **$525M** Jul 2011

**[Velocimed](https://millionrounds.com/company/velocimed)** Bought by [St. Jude Medical](https://millionrounds.com/fund/st-jude-medical) **$74M** Feb 2005

An exit counts when it came after the firm's first round in the company. From historical deal records.

New fund on file

**$275M**

raised in Mar 2021

From its SEC filing, not a journalist: a firm that has just raised has money to deploy.

## The cheque

Seed Series A Series B

Median round joined **$50M** the round, not its cheque Alone, median **$18M**

Led 1 of 39 rounds **3%**

- **Said size:** $100K – $10M
- **Sole investor:** 3 rounds
- **Last cheque:** Jun 2021
- **Exits:** 8 from the portfolio

Rounds by stage said on their site

- Series A said *10*
- Series B said *10*
- Series D *7*
- Series C *5*
- Venture *5*
- Series E *2*
- Seed said *-*

Cheques by year Led Joined

2003 2021

Often in the room with

- [Alta Partners](https://millionrounds.com/fund/alta-partners) 9
- [Arnerich Massena & Associates](https://millionrounds.com/fund/arnerich-massena-and-associates) 7
- [Novo Holdings](https://millionrounds.com/fund/novo-ventures) 7
- [3x5 Special Opportunity Fund](https://millionrounds.com/fund/3x5-special-opportunity-partners) 4
- [Domain Associates](https://millionrounds.com/fund/domain-associates) 4
- [Kaiser Permanente Ventures](https://millionrounds.com/fund/kaiser-permanente-ventures) 4

**Pitching RiverVest?** Put them on your fundraising board with this record on the card, and follow them to hear when they write a new cheque.

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## Who they invest alongside

The investors most often in the same rounds as RiverVest. A count of rooms they were both in, not a relationship either has claimed.

[**Alta Partners** VC firm **9** rounds together](https://millionrounds.com/fund/alta-partners)[**Arnerich Massena & Associates** Growth equity **7** rounds together](https://millionrounds.com/fund/arnerich-massena-and-associates)[**Novo Holdings** VC firm **7** rounds together](https://millionrounds.com/fund/novo-ventures)[**3x5 Special Opportunity Fund** VC firm **4** rounds together](https://millionrounds.com/fund/3x5-special-opportunity-partners)[**Domain Associates** VC firm **4** rounds together](https://millionrounds.com/fund/domain-associates)[**Kaiser Permanente Ventures** Corporate VC **4** rounds together](https://millionrounds.com/fund/kaiser-permanente-ventures)[**New Enterprise Associates** VC firm **4** rounds together](https://millionrounds.com/fund/new-enterprise-associates)[**PTV Sciences** VC firm **4** rounds together](https://millionrounds.com/fund/ptv-sciences)[**Roche Venture Fund** Corporate VC **4** rounds together](https://millionrounds.com/fund/roche-venture-fund)[**TPG** Private equity **4** rounds together](https://millionrounds.com/fund/tpg)[**BBT Fund** Investment firm **3** rounds together](https://millionrounds.com/fund/bbt-fund)[**Essex Woodlands Healthcare Partners** VC firm **3** rounds together](https://millionrounds.com/fund/essex-woodlands-health-ventures)

## Recently backed

The latest companies RiverVest put money into.

[**Standard Bariatrics** $35M · Jun 2021](https://millionrounds.com/company/standard-bariatrics)[**Arch Oncology** $50M · Mar 2019](https://millionrounds.com/company/arch-oncology)

## Quick answers about RiverVest

### What does RiverVest invest in?

RiverVest invests most often at Series A and Series B (51% of the rounds on record), in sectors such as Life Sciences, Biotechnology and Therapeutics.

### How active is RiverVest?

39 investments on record, 0 of them in the last 12 months, and it led 1. The most recent was in Jun 2021.

### What has RiverVest invested in recently?

Its most recent investments on record: Standard Bariatrics (Series B, Jun 2021), Intervene (Series B, Jun 2019) and Reneo Pharmaceuticals (Series A, May 2019).

### How big are RiverVest's cheques?

The median round it joins is $50M. It says it writes cheques of $100K to $10M.

### Does RiverVest lead rounds?

Sometimes: it led 1 of its 39 investments on record (3%).

### Where does RiverVest invest?

Most of the companies it backs are in the United States (100%).

### Is RiverVest investing now?

No investments in the last 12 months; the latest was in Jun 2021.

### Who does RiverVest invest alongside?

Most often Alta Partners (9 rounds together), Arnerich Massena & Associates (7 rounds together) and Novo Holdings (7 rounds together).

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