# ARCH Venture Partners: portfolio, investments and team

> ARCH Venture Partners is a vc firm based in United States. 337 investments on record, 41 in the last 12 months, latest Oct 2026.

Source: https://millionrounds.com/fund/arch-venture-partners (Millionrounds; every figure on the page links to its filing or article)

United States · [Investor](https://millionrounds.com/investors)

# ARCH Venture Partners

Last cheque observed Oct 2026; 337 cheques on record.

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Deploying now New fund $2.8B, Aug 2026 VC firm

Seed Series A Series B Information Technology Life Sciences Physical Sciences

Follow ARCH Venture Partners and see its new cheques in your feed. [Start following](https://millionrounds.com/login?join=1&why=follow&next=%2Ffund%2Farch-venture-partners)

Deploying now

**84%** of best year **41** **cheques in 12 months**, 337 on record

Since the last cheque **11** days **00** hrs **00** min **00** sec

Median round **$74M** Cheque size, as they say **$50K – $150M** Rounds led **12 of 337** Sole investor **17 rounds** Exits **19 from the portfolio** Mostly in **United States, 92%**

Pitch ARCH Venture Partners

## ARCH Venture Partners highlights

- 01 41 cheques in the last 12 months
- 02 Mostly Series A and Series B: 61% of its rounds
- 03 Sole investor in 17 rounds, median $18M
- 04 19 exits from the portfolio

## What they do

> ARCH Venture Partners provides seed / early stage venture capital for technology firms in information technology, life sciences, and physical sciences From their own website

- **Type:** VC firm (from a list, unverified)
- **Cheque size:** $50K – $150M as they say
- **Stages:** Seed Series A Series B Growth
- **Sectors:** Information Technology Life Sciences Physical Sciences
- **Based in:** Chicago, United States
- **Cold pitches:** Not stated

## The record

Every round we can evidence, newest first **337 appearances**

- **2026** 31 rounds
- **Oct** **[Soufflé Therapeutics](https://millionrounds.com/company/souffle-therapeutics)** Series B · US · Google News search **$135M** With 16 others
- **Oct** **[Oratomic](https://millionrounds.com/company/oratomic)** Series B · US · Silicon Angle **$475M** *Led*
- **Sept** **[Encoded Therapeutics](https://millionrounds.com/company/encoded-therapeutics)** Series F · US **$275M** With 4 others
- **Sept** **[Moonwalk Biosciences](https://millionrounds.com/company/moonwalk-biosciences)** Series B · US **$70M** With 4 others
- **Sept** **[Ramona](https://millionrounds.com/company/ramona)** Series A · US **$25M** With 2 others
- **Jul** **[Oratomic](https://millionrounds.com/company/oratomic)** Series A · US · TechCrunch **$300M** *Led*
- **Jul** **[Erasca](https://millionrounds.com/company/erasca)** US **$633M** With 4 others
- **Jun** **[SonoThera](https://millionrounds.com/company/sonothera)** Series B · US · Ventureburn **$125M** *Led*
- **Jun** **[Prometheus](https://millionrounds.com/company/prometheus)** Series B · US · TechCrunch **$12B** With 7 others
- **Jun** **[City Therapeutics](https://millionrounds.com/company/city-therapeutics)** Series B · US · Ventureburn **$100M** With 8 others
- **Jun** **[Parabilis Medicines](https://millionrounds.com/company/parabilis-medicines)** US **$75M** With 4 others
- **Jun** **[Trase](https://millionrounds.com/company/trase)** Seed · US **$107M** With 1 other
- **Jun** **[Ollin Biosciences](https://millionrounds.com/company/ollin-biosciences)** Series B · US **$330M** With 4 others
- **May** **[Countable Labs](https://millionrounds.com/company/countable-labs)** Series A · Ventureburn **$26M** *Led*
- **May** **[CREATE Medicines](https://millionrounds.com/company/create-medicines)** Series B · US · Hatteras Venture Partners **$122M** *Led*
- **May** **[Sana Biotechnology](https://millionrounds.com/company/sana-biotechnology)** US **$69M** With 4 others
- **Apr** **[Lightcast](https://millionrounds.com/company/lightcast)** Venture · GB · Ventureburn **$27M** *Led*
- **Apr** **[Moleculent](https://millionrounds.com/company/moleculent)** Series A · SE **$20M** Sole investor
- **Apr** **[Maze Therapeutics](https://millionrounds.com/company/maze-therapeutics)** US **$150M** With 5 others
- **Mar** **[Seaport Therapeutics](https://millionrounds.com/company/seaport-therapeutics)** Grant · US **$15M** With 2 others
- **Mar** **[Atlas Data Storage](https://millionrounds.com/company/atlas-data-storage)** Venture · US **Undisclosed** With 2 others
- **Mar** **[Scholar Rock](https://millionrounds.com/company/scholar-rock)** Debt · US **$100M** With 3 others
- **Feb** **[Salma Health](https://millionrounds.com/company/salma-health)** Series A · US **$80M** With 1 other
- **Feb** **[Beam Therapeutics](https://millionrounds.com/company/beam-therapeutics)** Debt · US **$100M** With 5 others
- **Feb** **[Syndex Bio](https://millionrounds.com/company/syndex-bio)** Seed · GB **$16M** Sole investor
- **Feb** **[Vir Biotechnology](https://millionrounds.com/company/vir-biotechnology)** US **$150M** With 4 others
- **Jan** **[Just - Evotec Biologics](https://millionrounds.com/company/just-evotec-biologics)** Venture · US **Undisclosed** With 3 others
- **Jan** **[Vizgen](https://millionrounds.com/company/vizgen)** Series E · US **$48M** With 1 other
- **Jan** **[bit.bio](https://millionrounds.com/company/bit-bio)** Series C **$50M** With 5 others
- **Jan** **[Mirador Therapeutics](https://millionrounds.com/company/mirador-therapeutics)** Series B · US **$250M** With 6 others
- **Jan** **[Parabilis Medicines](https://millionrounds.com/company/parabilis-medicines)** Series F · US **$305M** With 4 others
- **2025** 34 rounds
- **Dec** **[Aledade](https://millionrounds.com/company/aledade)** Debt · US **$500M** With 4 others
- **Dec** **[Denali Therapeutics](https://millionrounds.com/company/denali-therapeutics)** Debt · US **$200M** With 3 others
- **Dec** **[SciNeuro](https://millionrounds.com/company/scineuro)** Venture · US **$53M** With 3 others
- **Dec** **[Paradigm](https://millionrounds.com/company/paradigm)** Series B · US **$78M** With 3 others
- **Nov** **[Aspen Neuroscience](https://millionrounds.com/company/aspen-neuroscience)** Series C · US · Ventureburn **$115M** *Led*
- **Nov** **[Synchron](https://millionrounds.com/company/synchron)** Series D · US · Startup Daily **$305M** With 13 others
- **Nov** **[Sonoma Biotherapeutics](https://millionrounds.com/company/sonoma-biotherapeutics)** Grant · US **$300K** With 4 others
- **Nov** **[Lifordi Immunotherapeutics](https://millionrounds.com/company/lifordi-immunotherapeutics)** Venture · US **$42M** With 3 others
- **Nov** **[Gate Bioscience](https://millionrounds.com/company/gate-bioscience)** Series B · US **$65M** With 5 others

An announcement gives the size of the round, not the size of this investor's cheque: the only rounds that imply a cheque are those where they were the sole named investor.

## The team

Named by the firm itself, on a filing, its Form ADV or its company registration **9 named**

CW **Clinton Whitewood Bybee** Managing Director of the General Partner. i Filing they signed

JL **Jason L. Doren** General Counsel of the GP LLC i Filing they signed

KL **Keith Lawrence Crandell** Managing Director, President, Secretary and Shareholder i Form ADV

KM **Kristina Marie Burow** Managing Director, Vice President, and Shareholder i Form ADV

MA **Mark Andrew Mcdonnell** Managing Director of the General Partner. i Filing they signed

PT **Paul T. Berns** Managing Director of the GP LLC i Filing they signed

PT **Paul T. Thurk** Managing Director of the General Partner. i Filing they signed

RT **Robert Taylor Nelsen** Managing Director of the General Partner. i Filing they signed

SL **Steven L. Gillis** Managing Director of the General Partner i Filing they signed

We also hold **56** people at this firm from the lists this database was built from: a weaker source than the filings, since a list does not say when a title ended. Login to see them.

## What the register says

From the firm's own filings with the SEC, which it must file accurately by law

**$11B** gross assets of its funds Oct 2026

**Exempt** reporting adviser venture or small private funds

- **Legal name:** ARCH Venture Management LLC
- **SEC number:** CRD 158196

Who backs their funds

## 1 LP on record in ARCH Venture Partners's funds

- **Committed:** $30M
- **Funds:** 1
- **Vintages:** 2004

The institutions that put money into its funds, which the firm then invests in companies. Source: the pension's own report, latest Jun 2025.

- [**California State Teachers Retirement System** 1 fund *$30M*](https://millionrounds.com/fund/california-state-teachers-retirement-system) Fund Vintage Committed ARCH Venture Fund VI 2004 $30M

## What they claim to have backed

From their own portfolio page (on their website)

**60** of 60 we have independently watched raise

[908 Devices](https://millionrounds.com/company/908-devices)[Accompany Health](https://millionrounds.com/company/accompany-health)[Agios Pharmaceuticals](https://millionrounds.com/company/agios-pharmaceuticals)[Akamis Bio](https://millionrounds.com/company/akamis-bio)[Aledade](https://millionrounds.com/company/aledade)[Altos Labs](https://millionrounds.com/company/altos-labs)[Arbor Biotechnologies](https://millionrounds.com/company/arbor-biotechnologies)[Arraybiopharma](https://millionrounds.com/company/array-biopharma)[Arsenal Biosciences](https://millionrounds.com/company/arsenalbio)[Aspen Neuroscience](https://millionrounds.com/company/aspen-neuroscience)[BE Biopharma](https://millionrounds.com/company/be-biopharma)[Basking Biosciences](https://millionrounds.com/company/basking-biosciences)[Bluebirdbio](https://millionrounds.com/company/bluebird-bio)[Boundlessbio](https://millionrounds.com/company/boundless-bio)[Brii Biosciences](https://millionrounds.com/company/brii-biosciences)[CStone Pharmaceuticals](https://millionrounds.com/company/cstone-pharmaceuticals)[Carricktherapeutics](https://millionrounds.com/company/carrick-therapeutics)[Cytrellis Biosystems](https://millionrounds.com/company/cytrellis-biosystems)[Denali Therapeutics](https://millionrounds.com/company/denali-therapeutics)[Encoded Therapeutics](https://millionrounds.com/company/encoded-therapeutics)[Erasca](https://millionrounds.com/company/erasca)[Faraday Pharmaceuticals](https://millionrounds.com/company/faraday-pharmaceuticals)[Gate Bioscience](https://millionrounds.com/company/gate-bioscience)[Generate Biomedicines](https://millionrounds.com/company/generate-biomedicines)[Gossamerbio](https://millionrounds.com/company/gossamer-bio)[HiberCell](https://millionrounds.com/company/hibercell)[Homologymedicines](https://millionrounds.com/company/homology-medicines)[Huamedicine](https://millionrounds.com/company/hua-medicine)[JW Therapeutics](https://millionrounds.com/company/jw-therapeutics)[Jaguar Gene Therapy](https://millionrounds.com/company/jaguar-gene-therapy)[Kardigan](https://millionrounds.com/company/kardigan)[Kura Oncology](https://millionrounds.com/company/kura-oncology)[Lifordi Immunotherapeutics](https://millionrounds.com/company/lifordi-immunotherapeutics)[Lightcast Discovery](https://millionrounds.com/company/lightcast-discovery)[Magnet Biomedicine](https://millionrounds.com/company/magnet-biomedicine)[Matter Neuroscience](https://millionrounds.com/company/matter-neuroscience)[Moonwalk Biosciences](https://millionrounds.com/company/moonwalk-biosciences)[ONI](https://millionrounds.com/company/oni)[Omniome (Acquired)](https://millionrounds.com/company/omniome)[OneBioMed](https://millionrounds.com/company/one-biomed)[Parabilis Medicines](https://millionrounds.com/company/parabilis-medicines)[Pheast Therapeutics](https://millionrounds.com/company/pheast-therapeutics)[Protillion Biosciences](https://millionrounds.com/company/protillion-biosciences)[Qihan Biotech](https://millionrounds.com/company/qihan-biotech)[Quantum Circuits](https://millionrounds.com/company/quantum-circuits)[RIPPL Care](https://millionrounds.com/company/rippl-care)[Receptos](https://millionrounds.com/company/receptos)[Recuro Health](https://millionrounds.com/company/recuro-health)[Scholarrock](https://millionrounds.com/company/scholar-rock)[Singleron Biotechnologies](https://millionrounds.com/company/singleron-biotechnologies)[Slingshot Biosciences](https://millionrounds.com/company/slingshot-biosciences)[SunBird Bio](https://millionrounds.com/company/sunbird-bio)[Synchron](https://millionrounds.com/company/synchron)[Treeline Biosciences](https://millionrounds.com/company/treeline-biosciences)[Twist Bioscience](https://millionrounds.com/company/twist-bioscience)[Ultivue](https://millionrounds.com/company/ultivue)[Unitybiotechnology](https://millionrounds.com/company/unity-biotechnology)[Vir Biotechnology](https://millionrounds.com/company/vir-biotechnology)[Vividion](https://millionrounds.com/company/vividion-therapeutics)[Vizgen](https://millionrounds.com/company/vizgen) and 39 more

Weaker than a round we watched, stronger than a list somebody sold us. A firm is far less willing to put a company on its own site that it never funded.

## Exits from the portfolio

Companies it backed that were later bought or listed **19 in all**

**[Receptos](https://millionrounds.com/company/receptos)** Bought by [Celgene](https://millionrounds.com/fund/celgene) **$7.3B** Jul 2015

**[Kythera Biopharmaceuticals](https://millionrounds.com/company/kythera-biopharmaceuticals)** Bought by [Allergan](https://millionrounds.com/fund/allergan) **$2.1B** Jun 2015

**[Ikaria](https://millionrounds.com/company/ikaria)** Bought by [Mallinckrodt](https://millionrounds.com/fund/mallinckrodt) **$2.3B** Mar 2015

**[NextCode Health](https://millionrounds.com/company/nextcode-health)** Bought by [WuXi PharmaTech (Cayman)](https://millionrounds.com/fund/wuxi-pharmatech-cayman) **$65M** Jan 2015

**[Nitronex](https://millionrounds.com/company/nitronex)** Bought by M/A-COM Technology Solutions **$26M** Feb 2014

**[KOTURA](https://millionrounds.com/company/kotura)** Bought by [Mellanox Technologies](https://millionrounds.com/fund/mellanox-technologies) **$82M** Aug 2013

**[bluebird bio](https://millionrounds.com/company/bluebird-bio)** Listed **$101M** Jun 2013

**[Agios Pharmaceuticals](https://millionrounds.com/company/agios-pharmaceuticals)** Listed **$86M** Jun 2013

**[Innovalight](https://millionrounds.com/company/innovalight)** Bought by DuPont **Undisclosed** Jul 2011

**[Surface Logix](https://millionrounds.com/company/surface-logix)** Bought by Nano Terra **Undisclosed** Apr 2011

**[Ahura Scientific](https://millionrounds.com/company/ahura-scientific)** Bought by [Thermo Fisher Scientific](https://millionrounds.com/fund/thermo-fisher-scientific) **$145M** Jan 2010

**[Omeros](https://millionrounds.com/company/omeros)** Listed **Undisclosed** Oct 2009

**[Amphora Discovery](https://millionrounds.com/company/amphora-discovery)** Bought by Nanosyn **Undisclosed** Jul 2008

**[Univa UD](https://millionrounds.com/company/univa-ud)** Bought by Univa UD **Undisclosed** Oct 2007

**[Vascular Architects](https://millionrounds.com/company/vascular-architects)** Bought by LeMaitre Vascular **Undisclosed** Sept 2007

**[NeurogesX](https://millionrounds.com/company/neurogesx)** Listed **Undisclosed** Feb 2007

**[SilverStorm Technologies](https://millionrounds.com/company/silverstorm-technologies)** Bought by [QLogic](https://millionrounds.com/fund/qlogic) **Undisclosed** Oct 2006

**[NexCura](https://millionrounds.com/company/nexcura)** Bought by The Thompson Corporation **Undisclosed** Nov 2005

**[Teach.com](https://millionrounds.com/company/teach-com)** Bought by Intellinex **Undisclosed** Oct 2000

An exit counts when it came after the firm's first round in the company. From historical deal records.

New fund on file

**$2.8B**

raised in Aug 2026

From its SEC filing, not a journalist: a firm that has just raised has money to deploy.

## The cheque

Seed Series A Series B

Median round joined **$74M** the round, not its cheque Alone, median **$18M**

Led 12 of 337 rounds **4%**

- **Said size:** $50K – $150M
- **Sole investor:** 17 rounds
- **Last cheque:** Oct 2026
- **Exits:** 19 from the portfolio

Rounds by stage said on their site

- Series A said *91*
- Series B said *76*
- Venture *45*
- Series C *41*
- Series D *21*
- Seed said *-*
- Growth said *-*

Cheques by month Led Joined

Nov 2023 Oct 2026

Often in the room with

- [Polaris Partners](https://millionrounds.com/fund/polaris-partners) 34
- [Venrock](https://millionrounds.com/fund/venrock) 27
- [Fidelity](https://millionrounds.com/fund/fidelity) 24
- [Alexandria Real Estate Equities](https://millionrounds.com/fund/alexandria) 22
- [Google Ventures](https://millionrounds.com/fund/gv) 20
- [Versant Ventures](https://millionrounds.com/fund/versant-ventures) 16

**Pitching ARCH Venture Partners?** Put them on your fundraising board with this record on the card, and follow them to hear when they write a new cheque.

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## Who they invest alongside

The investors most often in the same rounds as ARCH Venture Partners. A count of rooms they were both in, not a relationship either has claimed.

[**Polaris Partners** VC firm **34** rounds together](https://millionrounds.com/fund/polaris-partners)[**Venrock** VC firm **27** rounds together](https://millionrounds.com/fund/venrock)[**Fidelity** VC firm **24** rounds together](https://millionrounds.com/fund/fidelity)[**Alexandria Real Estate Equities** VC firm **22** rounds together](https://millionrounds.com/fund/alexandria)[**Google Ventures** Corporate VC **20** rounds together](https://millionrounds.com/fund/gv)[**Versant Ventures** VC firm **16** rounds together](https://millionrounds.com/fund/versant-ventures)[**Lux Capital** VC firm **15** rounds together](https://millionrounds.com/fund/lux-capital)[**Alexandria Venture Investments** VC firm **14** rounds together](https://millionrounds.com/fund/alexandria-venture-investments)[**MPM Capital** Private equity **13** rounds together](https://millionrounds.com/fund/mpm-bioimpact)[**RA Capital Management** Private equity **13** rounds together](https://millionrounds.com/fund/ra-capital-management)[**5AM Ventures** VC firm **12** rounds together](https://millionrounds.com/fund/5am-ventures)[**Foresite Capital** Private equity **12** rounds together](https://millionrounds.com/fund/forsite-capital)

## Recently backed

The latest companies ARCH Venture Partners put money into.

[**Oratomic** $475M · Oct 2026](https://millionrounds.com/company/oratomic)[**Encoded Therapeutics** $275M · Sept 2026](https://millionrounds.com/company/encoded-therapeutics)[**Moonwalk Biosciences** $70M · Sept 2026](https://millionrounds.com/company/moonwalk-biosciences)[**Ramona** $25M · Sept 2026](https://millionrounds.com/company/ramona)[**Erasca** $633M · Jul 2026](https://millionrounds.com/company/erasca)[**SonoThera** $125M · Jun 2026](https://millionrounds.com/company/sonothera)

## Mentioned on podcasts

Episodes that name ARCH Venture Partners in their description, not their title.

- [Superclusters](https://millionrounds.com/podcasts/superclusters) 18 Mar 2024 · 1h 20m Diligence Questions: As Simple As They Are Complex | Youngrok Kim | Superclusters | S2E2 Mentions [ARCH Venture Partners](https://millionrounds.com/fund/arch-venture-partners)[Recruit Holdings](https://millionrounds.com/fund/recruit-holdings) Apple PodcastsShow page
- [BRAVE Southeast Asia Tech](https://millionrounds.com/podcasts/brave-southeast-asia) 13 May 2021 · 44 min Youngrok Kim on Japanese Corporate Venture Capital, Korea Army in Iraq & The Owner of Indeed & Glassdoor - E58 Mentions [ARCH Venture Partners](https://millionrounds.com/fund/arch-venture-partners) Apple PodcastsShow page

## Quick answers about ARCH Venture Partners

### What does ARCH Venture Partners invest in?

ARCH Venture Partners invests most often at Series A and Series B (61% of the rounds on record), in sectors such as Information Technology, Life Sciences and Physical Sciences.

### How active is ARCH Venture Partners?

337 investments on record, 41 of them in the last 12 months, and it led 12. The most recent was in Oct 2026.

### What has ARCH Venture Partners invested in recently?

Its most recent investments on record: Soufflé Therapeutics (Series B, Oct 2026), Oratomic (Series B, Oct 2026) and Encoded Therapeutics (Series F, Sept 2026).

### How big are ARCH Venture Partners's cheques?

The median round it joins is $74M. It says it writes cheques of $50K to $150M.

### Does ARCH Venture Partners lead rounds?

Sometimes: it led 12 of its 337 investments on record (4%).

### Where does ARCH Venture Partners invest?

Most of the companies it backs are in the United States (92%) and the United Kingdom (5%).

### Is ARCH Venture Partners investing now?

Yes: it is actively investing, with 41 investments in the last 12 months.

### Who does ARCH Venture Partners invest alongside?

Most often Polaris Partners (34 rounds together), Venrock (27 rounds together) and Fidelity (24 rounds together).

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