# Apple Tree Partners: portfolio, investments and team

> Apple Tree Partners is a vc firm based in United States. 28 investments on record, latest Sept 2025. Portfolio, stages, co-investors and team.

Source: https://millionrounds.com/fund/apple-tree-partners (Millionrounds; every figure on the page links to its filing or article)

United States · [Investor](https://millionrounds.com/investors)

# Apple Tree Partners

Last cheque observed Sep 2025. Silence since then is not evidence of inactivity: our sources miss unannounced rounds.

Quiet New fund $14M, Nov 2013 VC firm

Seed Series A Series B Healthcare Mental Health Molecules

Cheques on record

**0%** of best year **0** **cheques in 12 months**, 28 on record

Since the last cheque **417** days **00** hrs **00** min **00** sec

Median round **$60M** Cheque size, as they say **$100K – $5.0M** Rounds led **0 of 28** Sole investor **5 rounds** Exits **3 from the portfolio** Mostly in **United States, 96%**

Pitch Apple Tree Partners

## Apple Tree Partners highlights

- 01 28 rounds on record
- 02 Mostly Series B and Series D: 50% of its rounds
- 03 Sole investor in 5 rounds, median $40M
- 04 3 exits from the portfolio

## What they do

> Apple Tree Partners (ATP). a pioneer in life sciences venture capital From their own website

- **Type:** VC firm (from a list, unverified)
- **Cheque size:** $100K – $5.0M as they say
- **Stages:** Seed Series A Series B Growth
- **Sectors:** Healthcare Mental Health Molecules
- **Based in:** New York, United States
- **Cold pitches:** Not stated

## The record

Every round we can evidence, newest first **28 appearances**

- **2025** 1 round
- **Sept** **[Galvanize Therapeutics, Inc](https://millionrounds.com/company/galvanize-therapeutics-inc)** Series C · US · Elevage Medical Technologies **$100M** With 10 others
- **2019** 1 round
- **Dec** **[Limelight Bio](https://millionrounds.com/company/limelight-bio)** US · FinSMEs **$75M** Sole investor
- **2018** 4 rounds
- **Dec** **[Akero Therapeutics](https://millionrounds.com/company/akero-therapeutics)** Series B · US · FinSMEs **$70M** With 9 others
- **Jun** **[Akero Therapeutics](https://millionrounds.com/company/akero-therapeutics)** Series A · US · FinSMEs **$65M** With 3 others
- **Apr** **[Corvidia](https://millionrounds.com/company/corvidia)** Series B · US · FinSMEs **$60M** With 8 others
- **Jan** **[Braeburn](https://millionrounds.com/company/braeburn)** Debt · US · FinSMEs **$110M** With 6 others
- **2017** 3 rounds
- **Jun** **[Syntimmune](https://millionrounds.com/company/syntimmune)** Series B · US · FinSMEs **$50M** Sole investor
- **Jan** **[Stoke Therapeutics](https://millionrounds.com/company/stoke-therapeutics)** Series A · US · FinSMEs **$40M** Sole investor
- **Jan** **[Elstar](https://millionrounds.com/company/elstar)** Series A · US · FinSMEs **$39M** Sole investor
- **2016** 2 rounds
- **Sept** **[ROX Medical](https://millionrounds.com/company/rox-medical)** Series E · US · FinSMEs **$40M** With 1 other
- **Jul** **[VytronUS](https://millionrounds.com/company/vytronus)** Series C · US · FinSMEs **$49M** With 2 others
- **2014** 6 rounds
- **Oct** **[Aileron Therapeutics](https://millionrounds.com/company/aileron-therapeutics)** Series E · US **$33M** With 6 others
- **Oct** **[VytronUS](https://millionrounds.com/company/vytronus)** Series B · US **$32M** With 2 others
- **Aug** **[Dermira](https://millionrounds.com/company/dermira)** Series C · US **$51M** With 7 others
- **Jul** **[Cerecor](https://millionrounds.com/company/cerecor)** Series B · US **$32M** With 2 others
- **Apr** **[Tendyne Holdings](https://millionrounds.com/company/tendyne-holdings)** Series C · US **$25M** Sole investor
- **Feb** **[Aurinia Pharmaceuticals](https://millionrounds.com/company/aurinia-pharmaceuticals)** CA **$52M** With 8 others
- **2013** 3 rounds
- **Nov** **[Aileron Therapeutics](https://millionrounds.com/company/aileron-therapeutics)** Series E · US · finsmes.com **$30M** With 5 others
- **May** **[Tokai Pharmaceuticals](https://millionrounds.com/company/tokai-pharmaceuticals)** Series E · US · fiercebiotech.com **$36M** With 1 other
- **Jan** **[Aileron Therapeutics](https://millionrounds.com/company/aileron-therapeutics)** Series D · US · finsmes.com **$12M** With 5 others
- **2011** 1 round
- **Sept** **[Tokai Pharmaceuticals](https://millionrounds.com/company/tokai-pharmaceuticals)** Series D · US · eon.businesswire.com **$23M** With 1 other
- **2009** 3 rounds
- **Aug** **[Gloucester Pharmaceuticals](https://millionrounds.com/company/gloucester-pharmaceuticals)** Series D · US · gloucesterpharma.com **$29M** With 4 others
- **Jun** **[Aileron Therapeutics](https://millionrounds.com/company/aileron-therapeutics)** Series D · US · zibb.com **$40M** With 6 others
- **Jun** **[Tokai Pharmaceuticals](https://millionrounds.com/company/tokai-pharmaceuticals)** Series D · US · onbiovc.com **$22M** With 1 other
- **2008** 1 round
- **Apr** **[Aileron Therapeutics](https://millionrounds.com/company/aileron-therapeutics)** Series B · US · boston.bizjournals.com **$11M** With 1 other
- **2007** 1 round
- **Jun** **[Aileron Therapeutics](https://millionrounds.com/company/aileron-therapeutics)** Series B · US **$7.0M** With 1 other
- **2006** 1 round
- **Dec** **[Aileron Therapeutics](https://millionrounds.com/company/aileron-therapeutics)** Series A · US · fiercebiotech.com **$7.0M** With 1 other
- **2000** 1 round
- **Mar** **[Cyrano Sciences](https://millionrounds.com/company/cyrano-sciences)** Venture · US **$23M** With 6 others

An announcement gives the size of the round, not the size of this investor's cheque: the only rounds that imply a cheque are those where they were the sole named investor.

## The team

Named by the firm itself, on a filing, its Form ADV or its company registration **1 named**

SL **Seth L. Harrison** Executive Officer i Filing they signed

We also hold **17** people at this firm from the lists this database was built from: a weaker source than the filings, since a list does not say when a title ended. Login to see them.

## What the register says

From the firm's own filings with the SEC, which it must file accurately by law

**$3.6B** gross assets of its funds Oct 2026

**Exempt** reporting adviser venture or small private funds

- **Legal name:** Apple TREE Venture Management LLC
- **SEC number:** CRD 163705

## What they claim to have backed

From their own portfolio page (on their website)

**1** of 16 we have independently watched raise

[company's](https://millionrounds.com/company/stoke-therapeutics) company's company's company's company's company's company's company's company's company's company's company's company's company's company's company's

Weaker than a round we watched, stronger than a list somebody sold us. A firm is far less willing to put a company on its own site that it never funded.

## Exits from the portfolio

Companies it backed that were later bought or listed **3 in all**

**[Tendyne Holdings](https://millionrounds.com/company/tendyne-holdings)** Bought by [Abbott Labs](https://millionrounds.com/fund/abbott-labs) **$250M** Jul 2015

**[Gloucester Pharmaceuticals](https://millionrounds.com/company/gloucester-pharmaceuticals)** Bought by [Celgene](https://millionrounds.com/fund/celgene) **$640M** Dec 2009

**[Cyrano Sciences](https://millionrounds.com/company/cyrano-sciences)** Bought by Smiths Detection **Undisclosed** Mar 2004

An exit counts when it came after the firm's first round in the company. From historical deal records.

New fund on file

**$14M**

raised in Nov 2013

From its SEC filing, not a journalist: a firm that has just raised has money to deploy.

## The cheque

Seed Series A Series B

Median round joined **$60M** the round, not its cheque Alone, median **$40M**

Led 0 of 28 rounds **0%**

- **Said size:** $100K – $5.0M
- **Sole investor:** 5 rounds
- **Last cheque:** Sept 2025
- **Exits:** 3 from the portfolio

Rounds by stage said on their site

- Series B said *7*
- Series D *5*
- Series E *4*
- Series A said *4*
- Series C *4*
- Seed said *-*
- Growth said *-*

Cheques by month Led Joined

Nov 2023 Oct 2026

Often in the room with

- [Novartis Venture Fund](https://millionrounds.com/fund/novartis-venture-fund) 11
- [Excel Venture Management](https://millionrounds.com/fund/excel-venture-management-llc) 4
- [New Enterprise Associates](https://millionrounds.com/fund/new-enterprise-associates) 4
- [Roche Venture Fund](https://millionrounds.com/fund/roche-venture-fund) 4
- [SR One](https://millionrounds.com/fund/sr-one) 4
- [Lilly Ventures](https://millionrounds.com/fund/lilly-ventures) 3

**Pitching Apple Tree Partners?** Put them on your fundraising board with this record on the card, and follow them to hear when they write a new cheque.

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## Who they invest alongside

The investors most often in the same rounds as Apple Tree Partners. A count of rooms they were both in, not a relationship either has claimed.

[**Novartis Venture Fund** Corporate VC **11** rounds together](https://millionrounds.com/fund/novartis-venture-fund)[**Excel Venture Management** VC firm **4** rounds together](https://millionrounds.com/fund/excel-venture-management-llc)[**New Enterprise Associates** VC firm **4** rounds together](https://millionrounds.com/fund/new-enterprise-associates)[**Roche Venture Fund** Corporate VC **4** rounds together](https://millionrounds.com/fund/roche-venture-fund)[**SR One** Corporate VC **4** rounds together](https://millionrounds.com/fund/sr-one)[**Lilly Ventures** Corporate VC **3** rounds together](https://millionrounds.com/fund/lilly-ventures)[**venBio Partners** VC firm **3** rounds together](https://millionrounds.com/fund/venbio)[**Atlas** Private equity **2** rounds together](https://millionrounds.com/fund/atlas-2)[**BioStar Ventures** VC firm **2** rounds together](https://millionrounds.com/fund/biostar-ventures)[**Canaan** VC firm **2** rounds together](https://millionrounds.com/fund/canaan-partners)[**Cormorant Capital** VC firm **2** rounds together](https://millionrounds.com/fund/cormorant-capital)[**RA Capital Management** Private equity **2** rounds together](https://millionrounds.com/fund/ra-capital-management)

## Recently backed

The latest companies Apple Tree Partners put money into.

[**Akero Therapeutics** $70M · Dec 2018](https://millionrounds.com/company/akero-therapeutics)[**Braeburn** $110M · Jan 2018](https://millionrounds.com/company/braeburn)[**Syntimmune** $50M · Jun 2017](https://millionrounds.com/company/syntimmune)[**Stoke Therapeutics** $40M · Jan 2017](https://millionrounds.com/company/stoke-therapeutics)[**VytronUS** $49M · Jul 2016](https://millionrounds.com/company/vytronus)

## Quick answers about Apple Tree Partners

### What does Apple Tree Partners invest in?

Apple Tree Partners invests most often at Series B and Series D (50% of the rounds on record), in sectors such as Healthcare, Mental Health and Molecules.

### How active is Apple Tree Partners?

28 investments on record, 0 of them in the last 12 months. The most recent was in Sept 2025.

### What has Apple Tree Partners invested in recently?

Its most recent investments on record: Galvanize Therapeutics, Inc (Series C, Sept 2025), Limelight Bio (Undisclosed round, Dec 2019) and Akero Therapeutics (Series B, Dec 2018).

### How big are Apple Tree Partners's cheques?

The median round it joins is $60M. It says it writes cheques of $100K to $5.0M.

### Does Apple Tree Partners lead rounds?

Rarely, if at all: none of its 28 investments on record names it as the lead.

### Where does Apple Tree Partners invest?

Most of the companies it backs are in the United States (96%).

### Is Apple Tree Partners investing now?

No investments in the last 12 months; the latest was in Sept 2025.

### Who does Apple Tree Partners invest alongside?

Most often Novartis Venture Fund (11 rounds together), Excel Venture Management (4 rounds together) and New Enterprise Associates (4 rounds together).

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