# 406 Ventures: portfolio, investments and team

> 406 Ventures is a vc firm based in United States. 136 investments on record, 6 in the last 12 months, latest Oct 2026. Portfolio, stages, co-investors and team.

Source: https://millionrounds.com/fund/406-ventures (Millionrounds; every figure on the page links to its filing or article)

United States · [Investor](https://millionrounds.com/investors)

# 406 Ventures

Last cheque observed Oct 2026; 136 cheques on record.

Email

Deploying now New fund $245M, Feb 2024 VC firm

Pre-seed Seed Series A Healthcare Data AI

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Deploying now

**46%** of best year **6** **cheques in 12 months**, 136 on record

Since the last cheque **23** days **00** hrs **00** min **00** sec

Median round **$15M** Rounds led **5 of 136** Sole investor **16 rounds** Exits **7 from the portfolio** Mostly in **United States, 90%**

Pitch 406 Ventures

## 406 Ventures highlights

- 01 6 cheques in the last 12 months
- 02 Mostly Series A and Series B: 58% of its rounds
- 03 Sole investor in 16 rounds, median $4.5M
- 04 7 exits from the portfolio

## What they do

>.406 Ventures is the partner for early-stage companies with home run potential. From their own website

- **Type:** VC firm (from a list, unverified)
- **Cheque size:** Not stated
- **Stages:** Pre-seed Seed Series A Series B Growth Pre-IPO
- **Sectors:** Healthcare Data AI
- **Based in:** Boston, United States
- **Cold pitches:** Not stated

## The record

Every round we can evidence, newest first **136 appearances**

- **2026** 4 rounds
- **Oct** **[Vitalize](https://millionrounds.com/company/vitalize)** Series A · US · MedCity News **$31M** With 6 others
- **Aug** **[Mindgard](https://millionrounds.com/company/mindgard)** Series A · GB **$30M** With 3 others
- **Jun** **[InStride Health](https://millionrounds.com/company/instride-health)** Series C · US · Echo Health Ventures **$30M** With 5 others
- **Feb** **[Big Health](https://millionrounds.com/company/big-health)** US · Gilde Healthcare **$24M** *Led*
- **2025** 10 rounds
- **Dec** **[Nomad Health](https://millionrounds.com/company/nomad-health)** Venture · US **$34M** With 7 others
- **Nov** **[FamilyWell Health](https://millionrounds.com/company/familywell-health)** Series A · US **$8.0M** Sole investor
- **Oct** **[Indico Data](https://millionrounds.com/company/indico-data)** Venture · US **Undisclosed** With 5 others
- **Sept** **[Diana Health](https://millionrounds.com/company/diana-health)** Series C · US **$55M** With 4 others
- **Sept** **[RapidFire AI](https://millionrounds.com/company/rapidfire-ai)** Pre-seed · US **$4.0M** Sole investor
- **Jul** **[Equip Health](https://millionrounds.com/company/equip-health)** Venture · US **$47M** With 4 others
- **May** **[Redox](https://millionrounds.com/company/redox)** US **$12M** With 3 others
- **Mar** **[Bluebird Kids Health](https://millionrounds.com/company/bluebird-kids-health)** Series A · US **$32M** Sole investor
- **Feb** **[Rad Security](https://millionrounds.com/company/rad-security)** Series A · US **$14M** With 2 others
- **Feb** **[Lynx](https://millionrounds.com/company/lynx)** Series A · GB **$27M** With 3 others
- **2024** 11 rounds
- **Dec** **[Mindgard](https://millionrounds.com/company/mindgard)** Venture · GB **$8.2M** With 3 others
- **Dec** **[Tausight](https://millionrounds.com/company/tausight)** Venture · US **Undisclosed** With 4 others
- **Nov** **[Nema Health](https://millionrounds.com/company/nema-health)** Series A · US **$15M** With 2 others
- **Nov** **[Cortica](https://millionrounds.com/company/cortica)** Venture · IL **$80M** With 5 others
- **Jul** **[Heartbeat Health](https://millionrounds.com/company/heartbeat-health)** Series C · US **$25M** With 4 others
- **Jun** **[HYPR](https://millionrounds.com/company/hypr)** Venture · US **$30M** With 3 others
- **Jun** **[Humata Health](https://millionrounds.com/company/humata-health)** Series A · US **$25M** With 2 others
- **May** **[OncoveryCare](https://millionrounds.com/company/oncoverycare)** Seed · US **$4.5M** With 1 other
- **May** **[Wayspring](https://millionrounds.com/company/wayspring)** Series D · US **$45M** Sole investor
- **Mar** **[Tausi](https://millionrounds.com/company/tausi)** Pre-seed · US **$450K** With 4 others
- **Mar** **[InStride Health](https://millionrounds.com/company/instride-health)** Series B · US **$30M** With 1 other
- **2023** 10 rounds
- **Nov** **[AristaMD](https://millionrounds.com/company/aristamd)** Series C · US **$17M** With 2 others
- **Aug** **[Better Life Partners](https://millionrounds.com/company/better-life-partners)** Series B · US **$27M** With 2 others
- **Aug** **[Simon Data](https://millionrounds.com/company/simon-data)** Series D · US **$54M** With 4 others
- **Aug** **[Simon AI](https://millionrounds.com/company/simon-ai)** Series D · US **$54M** With 4 others
- **Jul** **[Portrait Analytics](https://millionrounds.com/company/portrait-analytics)** Seed · US **$7.0M** With 1 other
- **Jun** **[Laudio](https://millionrounds.com/company/laudio)** Series B · US **$13M** Sole investor
- **Jun** **[Sevco Security](https://millionrounds.com/company/sevco-security)** Venture · US **$17M** With 3 others
- **Jun** **[Telmai](https://millionrounds.com/company/telmai)** Seed · US **$5.5M** With 3 others
- **Apr** **[Bobsled, Inc.](https://millionrounds.com/company/bobsled-inc)** Series A · US **$17M** With 4 others
- **Feb** **[Wellist](https://millionrounds.com/company/wellist)** Debt · US **$165K** Sole investor
- **2022** 8 rounds
- **Dec** **[Trilio](https://millionrounds.com/company/trilio)** Series B · US **$17M** With 1 other
- **Dec** **[retrain.ai](https://millionrounds.com/company/retrain-ai)** Venture · US **$14M** With 2 others
- **Oct** **[Oort](https://millionrounds.com/company/oort)** Series A · US **$12M** With 4 others
- **Aug** **[ClosedLoop](https://millionrounds.com/company/closedloop)** Venture · US **$25K** With 5 others
- **Aug** **[ThreatX](https://millionrounds.com/company/threat-x)** Series B · US **$30M** With 1 other

An announcement gives the size of the round, not the size of this investor's cheque: the only rounds that imply a cheque are those where they were the sole named investor.

## The team

Named by the firm itself, on a filing, its Form ADV or its company registration **10 named**

GD **Gregory Dracon** Partner of the General Partner i Filing they signed

JG **John Graham Brooks** Partner of the General Partner i Filing they signed

LB **Lawrence Begley** Member of.406 Ventures II GP, LLC (the ""GP LLC""), the general partner of.406 Ventures II GP, L.P. (the ""General Partner""), the general partner i Filing they signed

LS **Liam Sean Donohue** Member of the general partner of the Issuer's Manager i Filing they signed

MC **Maria Cirino** Member of the general partner of the Issuer's Manager i Filing they signed

PE **Paul E. Walker** Manager of the General Partner. i Filing they signed

PD **Payal Divakaran** Partner of the General Partner i Filing they signed

RC **Rick C. Yang** Manager of the General Partner. i Filing they signed

SD **Scott D. Sandell** Manager of the General Partner. i Filing they signed

SM **So-June Min Donohue** Director i Form ADV

We also hold **21** people at this firm from the lists this database was built from: a weaker source than the filings, since a list does not say when a title ended. Login to see them.

## What the register says

From the firm's own filings with the SEC, which it must file accurately by law

**$1.6B** gross assets of its funds Oct 2026

**Exempt** reporting adviser venture or small private funds

- **Legal name:**.406 Ventures Management, L.P.
- **SEC number:** CRD 162914

## What they claim to have backed

From their own portfolio page (on their website)

**29** of 50 we have independently watched raise

[Abacusinsights](https://millionrounds.com/company/abacus-insights)[Absurd](https://millionrounds.com/company/absurd)[Aristamd](https://millionrounds.com/company/aristamd)[Bighealth](https://millionrounds.com/company/big-health)[Chaossearch](https://millionrounds.com/company/chaossearch)[Closedloop](https://millionrounds.com/company/closedloop)[Corp](https://millionrounds.com/company/kaltura)[Familywellhealth](https://millionrounds.com/company/familywell-health)[Genesiscomputing](https://millionrounds.com/company/genesis-computing)[Heartbeathealth](https://millionrounds.com/company/heartbeat-health)[Hypr](https://millionrounds.com/company/hypr)[Indicodata](https://millionrounds.com/company/indico-data)[Keebo](https://millionrounds.com/company/keebo)[Mindgard](https://millionrounds.com/company/mindgard)[Nemahealth](https://millionrounds.com/company/nema-health)[Onapsis](https://millionrounds.com/company/onapsis)[Oncoverycare](https://millionrounds.com/company/oncoverycare)[Portraitanalytics](https://millionrounds.com/company/portrait-analytics)[Promethium](https://millionrounds.com/company/promethium)[Radsecurity](https://millionrounds.com/company/rad-security)[Randori](https://millionrounds.com/company/randori)[Redoxengine](https://millionrounds.com/company/redox)[Relai](https://millionrounds.com/company/relai)[Trilio](https://millionrounds.com/company/trilio)[Valeriehealth](https://millionrounds.com/company/valerie-health)[Vitalize](https://millionrounds.com/company/vitalize)[Wayspring](https://millionrounds.com/company/wayspring)[Welbehealth](https://millionrounds.com/company/welbehealth)[Wellist](https://millionrounds.com/company/wellist) Arboretum Ascellus Biadvisors Bluebirdkids Bobsled Clarenhealth Corticacare Equip Gamestrong Helmhealth Heydianahealth Instride Lynx-fh Nace Onbelayhealthsolutions Quellsecure Rapidfire Rooncyber Sevco Telm Thetasoftware

Weaker than a round we watched, stronger than a list somebody sold us. A firm is far less willing to put a company on its own site that it never funded.

## Exits from the portfolio

Companies it backed that were later bought or listed **7 in all**

**[Digitalsmiths](https://millionrounds.com/company/digitalsmiths)** Bought by [TiVo](https://millionrounds.com/fund/tivo) **$135M** Jan 2014

**[WellAWARE Systems](https://millionrounds.com/company/wellaware-systems)** Bought by Healthsense **Undisclosed** Jul 2013

**[EnergyHub](https://millionrounds.com/company/energyhub)** Bought by [Alarm.com](https://millionrounds.com/fund/alarm-com) **Undisclosed** May 2013

**[Mashery](https://millionrounds.com/company/mashery)** Bought by [Intel](https://millionrounds.com/fund/intel) **Undisclosed** Apr 2013

**[Memento](https://millionrounds.com/company/memento)** Bought by [FIS](https://millionrounds.com/fund/fis-impact-ventures) **Undisclosed** Apr 2012

**[ThingMagic](https://millionrounds.com/company/thingmagic)** Bought by Trimble **Undisclosed** Oct 2010

**[PGP TrustCenter](https://millionrounds.com/company/pgp-trustcenter)** Bought by PGP Corporation **Undisclosed** Feb 2010

An exit counts when it came after the firm's first round in the company. From historical deal records.

New fund on file

**$245M**

raised in Feb 2024

From its SEC filing, not a journalist: a firm that has just raised has money to deploy.

## The cheque

Pre-seed Seed Series A

Median round joined **$15M** the round, not its cheque Alone, median **$4.5M**

Led 5 of 136 rounds **4%**

- **Sole investor:** 16 rounds
- **Last cheque:** Oct 2026
- **Exits:** 7 from the portfolio

Rounds by stage said on their site

- Series A said *48*
- Series B said *22*
- Series C *17*
- Venture *16*
- Seed said *10*
- Series D *7*
- Pre-seed said *-*

Cheques by month Led Joined

Nov 2023 Oct 2026

Often in the room with

- [Polaris Partners](https://millionrounds.com/fund/polaris-partners) 12
- [Atlas Venture](https://millionrounds.com/fund/atlas-venture) 11
- [Y Combinator](https://millionrounds.com/fund/y-combinator) 8
- [Founders Fund](https://millionrounds.com/fund/founders-fund) 7
- [General Catalyst](https://millionrounds.com/fund/general-catalyst) 6
- [Prism Venture Partners](https://millionrounds.com/fund/prism-venture-partners) 6

**Pitching 406 Ventures?** Put them on your fundraising board with this record on the card, and follow them to hear when they write a new cheque.

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## Who they invest alongside

The investors most often in the same rounds as 406 Ventures. A count of rooms they were both in, not a relationship either has claimed.

[**Polaris Partners** VC firm **12** rounds together](https://millionrounds.com/fund/polaris-partners)[**Atlas Venture** VC firm **11** rounds together](https://millionrounds.com/fund/atlas-venture)[**Y Combinator** Accelerator **8** rounds together](https://millionrounds.com/fund/y-combinator)[**Founders Fund** VC firm **7** rounds together](https://millionrounds.com/fund/founders-fund)[**General Catalyst** VC firm **6** rounds together](https://millionrounds.com/fund/general-catalyst)[**Prism Venture Partners** VC firm **6** rounds together](https://millionrounds.com/fund/prism-venture-partners)[**Techstars** VC firm **6** rounds together](https://millionrounds.com/fund/techstars)[**Thrive Capital** Family office **6** rounds together](https://millionrounds.com/fund/thrive-capital-2)[**Flare Capital** VC firm **5** rounds together](https://millionrounds.com/fund/flare-capital-partners)[**Marc Benioff** VC firm **5** rounds together](https://millionrounds.com/fund/marc-benioff)[**Accomplice** VC firm **4** rounds together](https://millionrounds.com/fund/accomplice)[**Advance Publications** Growth equity **4** rounds together](https://millionrounds.com/fund/advance-publications)

## Recently backed

The latest companies 406 Ventures put money into.

[**Vitalize** $31M · Oct 2026](https://millionrounds.com/company/vitalize)[**Mindgard** $30M · Aug 2026](https://millionrounds.com/company/mindgard)[**InStride Health** $30M · Jun 2026](https://millionrounds.com/company/instride-health)[**Nomad Health** $34M · Dec 2025](https://millionrounds.com/company/nomad-health)[**FamilyWell Health** $8.0M · Nov 2025](https://millionrounds.com/company/familywell-health)[**Indico Data** Oct 2025](https://millionrounds.com/company/indico-data)

## Quick answers about 406 Ventures

### What does 406 Ventures invest in?

406 Ventures invests most often at Series A and Series B (58% of the rounds on record), in sectors such as Healthcare, Data and AI.

### How active is 406 Ventures?

136 investments on record, 6 of them in the last 12 months, and it led 5. The most recent was in Oct 2026.

### What has 406 Ventures invested in recently?

Its most recent investments on record: Vitalize (Series A, Oct 2026), Mindgard (Series A, Aug 2026) and InStride Health (Series C, Jun 2026).

### How big are 406 Ventures's cheques?

The median round it joins is $15M.

### Does 406 Ventures lead rounds?

Sometimes: it led 5 of its 136 investments on record (4%).

### Where does 406 Ventures invest?

Most of the companies it backs are in the United States (90%) and the United Kingdom (8%).

### Is 406 Ventures investing now?

Yes: it is actively investing, with 6 investments in the last 12 months.

### Who does 406 Ventures invest alongside?

Most often Polaris Partners (12 rounds together), Atlas Venture (11 rounds together) and Y Combinator (8 rounds together).

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Built from the rounds we watched, its filings and its own website, refreshed every night. [How we count](https://millionrounds.com/methodology) · [Report a correction](https://millionrounds.com/corrections?slug=406-ventures) · [Is this your firm? Claim it](https://millionrounds.com/claim?org=406-ventures)