# Upstream Bio funding: rounds and investors

> Upstream Bio has raised $200M across 1 round since 2023. Investors include OrbiMed, Wellington Management and TCG. Every round with its source.

Source: https://millionrounds.com/company/upstream-bio (Millionrounds; every figure on the page links to its filing or article)

United States · [Series B startup](https://millionrounds.com/companies)

# Who invested in *Upstream Bio*

One round we have observed, with the 7 investors named in it. Every figure came from a named source, and where the company reported a raise to the SEC itself, that is shown beside it.

Biotech

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Funding summary Updated 27 Oct 2026

**$200M** raised across 1 round since 2023, from 1 source

- **Latest round:** Series B, $200M Jun 2023
- **Investors:** 7

See who backed them

## The rounds

- **Jun 2023** Series B **$200M** [OrbiMed](https://millionrounds.com/fund/orbimed) [Wellington Management](https://millionrounds.com/fund/wellington-management) [TCG](https://millionrounds.com/fund/tcg) [Omega Funds](https://millionrounds.com/fund/omega-funds) [Samsara BioCapital](https://millionrounds.com/fund/samsara-biocapital) [TCG Crossover](https://millionrounds.com/fund/tcg-crossover) [Bain Capital Life Sciences](https://millionrounds.com/fund/bain-capital-life-sciences) Source recorded

## Founders and team

From Upstream Bio's own website: 6 on the team.

- **Daniella Beckman** Chief Executive Officer
- **Amy Iannelli** Vice President, Finance
- **Ken Adams** Senior Vice President, Clinical Operations & Medical Writing
- **Lisa Fiering** Senior Vice President, People & Culture
- **Allison Ambrose** General Counsel
- **Ron Renaud** Chair, Board of Directors

## Everyone who backed them

[OrbiMed](https://millionrounds.com/fund/orbimed) Private equity **1** round

[Wellington Management](https://millionrounds.com/fund/wellington-management) VC firm **1** round

[TCG](https://millionrounds.com/fund/tcg) Private equity **1** round

[Omega Funds](https://millionrounds.com/fund/omega-funds) VC firm **1** round

[Samsara BioCapital](https://millionrounds.com/fund/samsara-biocapital) VC firm **1** round

[TCG Crossover](https://millionrounds.com/fund/tcg-crossover) VC firm **1** round

[Bain Capital Life Sciences](https://millionrounds.com/fund/bain-capital-life-sciences) Private equity **1** round

Missing a round, or an investor who was in one? [Tell us](https://millionrounds.com/corrections?slug=upstream-bio).

## Also claim to have backed them

This firm lists Upstream Bio as a portfolio company on their own website, but no report of a round names it. They are the firms' own claims, kept apart from the rounds above.

[Decheng Capital](https://millionrounds.com/fund/decheng-capital) VC firm Per its own site

## Quick answers about Upstream Bio

### Who invested in Upstream Bio?

Upstream Bio's investors include OrbiMed, Wellington Management, TCG, Omega Funds and Samsara BioCapital, and 2 more on record.

### How much has Upstream Bio raised?

Upstream Bio has raised $200M across 1 round since 2023.

### When did Upstream Bio last raise?

Upstream Bio's most recent round was a Series B of $200M in Jun 2023.

### What was Upstream Bio's biggest round?

Its most recent round, $200M in Jun 2023, is also its largest on record.

### Who backed Upstream Bio first?

Upstream Bio's first round on record, in Jun 2023, was backed by OrbiMed, Wellington Management and TCG and 4 others.

### What stage is Upstream Bio at?

Upstream Bio's latest named round is a Series B, in Jun 2023.

### Where is Upstream Bio based?

Upstream Bio is based in the United States.

## Companies like Upstream Bio

In the same sector, and raised in the last eighteen months.

[**Star Therapeutics** $325M · Oct 2026](https://millionrounds.com/company/star-therapeutics)[**Promaxo** $106M · Oct 2026](https://millionrounds.com/company/promaxo)[**Prolific Machines** $105M · Oct 2026](https://millionrounds.com/company/prolific-machines)[**IMIO** $19M · Oct 2026](https://millionrounds.com/company/imio)[**Rejuvenate Bio** $13M · Oct 2026](https://millionrounds.com/company/rejuvenate-bio)[**Clinical Ink** $24M · Oct 2026](https://millionrounds.com/company/clinical-ink)

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