# Main Street Health funding: rounds and investors

> Main Street Health has raised $347M across 2 rounds since 2023. Investors include Optum Ventures, Frist Cressey Ventures and Hercules Capital.

Source: https://millionrounds.com/company/main-street-health (Millionrounds; every figure on the page links to its filing or article)

United States · [Venture startup](https://millionrounds.com/companies)

# Who invested in *Main Street Health*

2 rounds we have observed, with the 3 investors named in them. Every figure came from a named source, and where the company reported a raise to the SEC itself, that is shown beside it.

Healthcare

Funding summary Updated 26 Oct 2026

**$347M** raised across 2 rounds since 2023, from 2 sources

**$315M** Venture **$32M** Venture

- **Latest round:** Venture, $32M Apr 2025
- **Biggest round:** $315M Venture · Oct 2023
- **Investors:** 3

See who backed them

## The funding story

Each circle is a round, placed by date and sized by amount. The line above is the running total.

2024 2025

**$315M** Venture

**$32M** Venture

- **First round:** Venture, $315M
- **Biggest round:** $315M
- **Between rounds:** 18 months

## The rounds

- **Apr 2025** Venture **$32M** *1 new* *2 returning* [Hercules Capital](https://millionrounds.com/fund/hercules-capital) [Optum Ventures](https://millionrounds.com/fund/optum-ventures) [Frist Cressey Ventures](https://millionrounds.com/fund/frist-cressey-ventures) Source recorded
- **Oct 2023** Venture **$315M** *2 new* [Optum Ventures](https://millionrounds.com/fund/optum-ventures) [Frist Cressey Ventures](https://millionrounds.com/fund/frist-cressey-ventures) Source recorded

## Who was in which round

The busiest backers across the latest rounds. A filled square is a round they joined; a dark one, a round they led.

**Venture** 2023 **Venture** 2025 [Optum Ventures](https://millionrounds.com/fund/optum-ventures) [Frist Cressey Ventures](https://millionrounds.com/fund/frist-cressey-ventures) [Hercules Capital](https://millionrounds.com/fund/hercules-capital)

## Everyone who backed them

[Optum Ventures](https://millionrounds.com/fund/optum-ventures) VC firm **2** rounds

[Frist Cressey Ventures](https://millionrounds.com/fund/frist-cressey-ventures) VC firm **2** rounds

[Hercules Capital](https://millionrounds.com/fund/hercules-capital) Venture debt **1** round

Missing a round, or an investor who was in one? [Tell us](https://millionrounds.com/corrections?slug=main-street-health).

## Quick answers about Main Street Health

### Who invested in Main Street Health?

Main Street Health's investors include Optum Ventures, Frist Cressey Ventures and Hercules Capital.

### How much has Main Street Health raised?

Main Street Health has raised $347M across 2 rounds since 2023.

### When did Main Street Health last raise?

Main Street Health's most recent round was a Venture of $32M in Apr 2025.

### What was Main Street Health's biggest round?

Main Street Health's largest round on record is $315M (Venture), in Oct 2023.

### Who backed Main Street Health first?

Main Street Health's first round on record, in Oct 2023, was backed by Optum Ventures and Frist Cressey Ventures.

### What stage is Main Street Health at?

Main Street Health's latest named round is a Venture, in Apr 2025.

### Where is Main Street Health based?

Main Street Health is based in the United States.

## Companies like Main Street Health

In the same sector, and raised in the last eighteen months.

[**Star Therapeutics** $325M · Oct 2026](https://millionrounds.com/company/star-therapeutics)[**Promaxo** $106M · Oct 2026](https://millionrounds.com/company/promaxo)[**AI** $18M · Oct 2026](https://millionrounds.com/company/ai)[**Baba** $40M · Oct 2026](https://millionrounds.com/company/baba)[**Rejuvenate Bio** $13M · Oct 2026](https://millionrounds.com/company/rejuvenate-bio)[**Clinical Ink** $24M · Oct 2026](https://millionrounds.com/company/clinical-ink)

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